Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for A2ARP9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7EEB | EM | 290 A | B | 1-588 | PDB |
| AF-A2ARP9-F1 | Predicted | AlphaFoldDB |
No variants for A2ARP9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A2ARP9 | |||||
No associated diseases with A2ARP9
1 regional properties for A2ARP9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Ion transport domain | 106 - 348 | IPR005821 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| CatSper complex | A sperm-specific voltage-gated calcium channel that controls the intracellular calcium ion concentration and, thereby, the swimming behavior of sperm. Consists of a heteromeric tetramer surrounding a calcium ion- selective pore. May also contain additional auxiliary subunits. |
| sperm flagellum | A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium activated cation channel activity | Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient. |
| calcium channel activity | Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| voltage-gated ion channel activity | Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| fertilization | The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). |
| flagellated sperm motility | The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm. |
| regulation of ion transmembrane transport | Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. |
| sperm capacitation | A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6YLX9 | TPC1 | Two pore calcium channel protein 1 | Triticum aestivum (Wheat) | PR |
| P91645 | MED20 | Voltage-dependent calcium channel type A subunit alpha-1 | Drosophila melanogaster (Fruit fly) | PR |
| Q86XQ3 | CATSPER3 | Cation channel sperm-associated protein 3 | Homo sapiens (Human) | PR |
| Q9UQD0 | SCN8A | Sodium channel protein type 8 subunit alpha | Homo sapiens (Human) | PR |
| Q9Y5Y9 | SCN10A | Sodium channel protein type 10 subunit alpha | Homo sapiens (Human) | PR |
| Q14524 | SCN5A | Sodium channel protein type 5 subunit alpha | Homo sapiens (Human) | PR |
| Q96P56 | CATSPER2 | Cation channel sperm-associated protein 2 | Homo sapiens (Human) | PR |
| Q9WTU3 | Scn8a | Sodium channel protein type 8 subunit alpha | Mus musculus (Mouse) | PR |
| Q6QIY3 | Scn10a | Sodium channel protein type 10 subunit alpha | Mus musculus (Mouse) | PR |
| Q62205 | Scn9a | Sodium channel protein type 9 subunit alpha | Mus musculus (Mouse) | PR |
| Q9JJV9 | Scn5a | Sodium channel protein type 5 subunit alpha | Mus musculus (Mouse) | PR |
| O88420 | Scn8a | Sodium channel protein type 8 subunit alpha | Rattus norvegicus (Rat) | PR |
| O88457 | Scn11a | Sodium channel protein type 11 subunit alpha | Rattus norvegicus (Rat) | PR |
| Q62968 | Scn10a | Sodium channel protein type 10 subunit alpha | Rattus norvegicus (Rat) | PR |
| Q5QM84 | TPC1 | Two pore calcium channel protein 1 | Oryza sativa subsp japonica (Rice) | PR |
| Q94KI8 | TPC1 | Two pore calcium channel protein 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAQEQGHFQL | LRADAIRSKL | IDTFSLIEHL | QGLSQAVPRH | TLREILDPSY | QQKLMSGDQE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QLVRFSIKPR | RMGHITHSRR | LLSRLRVRCS | RMPPLSLWAG | WVLDSSVFSK | FIISLIFLNT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FVLMVEIELM | ESTNTALWPV | KLALEVADWF | ILLSFIVEIL | LMWLASFSLF | WKDAWNVFDF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FVTLLSLLPE | LVVLLGVPAH | SVWLQLLRVC | RVLRSLKLFA | RFRQIKVILL | ALVRALKSMT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FLLMLLLIFF | YIFAVTGVYF | FREYSRSTIE | GLEYNMFFSD | LLNSLVTVFI | LFTLDHWYAV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LQDIWKVPES | SRVFSSIYVI | LWLLLGSIIF | RNIIVAMMVT | NFQNIRSELS | EEMSHLEVQY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KADMFKQQII | QRRQHSESLR | GTSLGKVSED | IIETSDASDD | DDDDDDDDDD | DDDDDDDKSD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ATESDNEESD | SENSESENSE | SEKIDPEKDY | AKKSYPEKSH | PEKSYPEKSH | PEKSYPEKSH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PKKSYDEQAE | AEKVKEESKE | KAYPVSHSIS | SHGSTAADTA | FLENLDWETL | VHENLPGLMD |
| 550 | 560 | 570 | 580 | ||
| MDQDDRIVWP | RDSLFRYFEL | LEKLQYNLEE | RKKLQEFAVQ | ALMSFEDK |