O88420
PR
Gene name |
Scn8a |
Protein name |
Sodium channel protein type 8 subunit alpha |
Names |
Peripheral nerve protein type 4, PN4, Sodium channel 6, NaCh6, Sodium channel protein type VIII subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.6 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:29710 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O88420
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O88420-F1 | Predicted | AlphaFoldDB |
No variants for O88420
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O88420 | |||||
No associated diseases with O88420
8 regional properties for O88420
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| binding_site | IQ motif, EF-hand binding site | 1892 - 1922 | IPR000048 |
| domain | Ion transport domain | 131 - 421 | IPR005821-1 |
| domain | Ion transport domain | 752 - 979 | IPR005821-2 |
| domain | Ion transport domain | 1195 - 1470 | IPR005821-3 |
| domain | Ion transport domain | 1520 - 1774 | IPR005821-4 |
| domain | Sodium ion transport-associated domain | 989 - 1190 | IPR010526 |
| domain | Voltage-gated Na+ ion channel, cytoplasmic domain | 546 - 700 | IPR024583 |
| domain | Voltage-gated sodium channel alpha subunit, inactivation gate | 1463 - 1515 | IPR044564 |
15 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| axon initial segment | Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of postsynaptic density membrane | The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of presynaptic active zone membrane | The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| node of Ranvier | An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed. |
| parallel fiber to Purkinje cell synapse | An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| sodium channel complex | An ion channel complex through which sodium ions pass. |
| voltage-gated sodium channel complex | A sodium channel in a cell membrane whose opening is governed by the membrane potential. |
| Z disc | Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| sodium ion binding | Binding to a sodium ion (Na+). |
| voltage-gated ion channel activity | Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| voltage-gated sodium channel activity | Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
14 GO annotations of biological process
| Name | Definition |
|---|---|
| adult locomotory behavior | Locomotory behavior in a fully developed and mature organism. |
| adult walking behavior | The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg. |
| locomotory behavior | The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. |
| membrane depolarization during action potential | The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. |
| muscle organ development | The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. |
| myelination | The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. |
| neuromuscular process | Any process pertaining to the functions of the nervous and muscular systems of an organism. |
| neuronal action potential | An action potential that occurs in a neuron. |
| peripheral nervous system development | The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. |
| regulation of ion transmembrane transport | Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. |
| response to toxic substance | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. |
| sensory perception of sound | The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| sodium ion transport | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6YLX9 | TPC1 | Two pore calcium channel protein 1 | Triticum aestivum (Wheat) | PR |
| P91645 | MED20 | Voltage-dependent calcium channel type A subunit alpha-1 | Drosophila melanogaster (Fruit fly) | PR |
| Q86XQ3 | CATSPER3 | Cation channel sperm-associated protein 3 | Homo sapiens (Human) | PR |
| Q96P56 | CATSPER2 | Cation channel sperm-associated protein 2 | Homo sapiens (Human) | PR |
| Q9Y5Y9 | SCN10A | Sodium channel protein type 10 subunit alpha | Homo sapiens (Human) | PR |
| Q14524 | SCN5A | Sodium channel protein type 5 subunit alpha | Homo sapiens (Human) | PR |
| Q9UQD0 | SCN8A | Sodium channel protein type 8 subunit alpha | Homo sapiens (Human) | PR |
| A2ARP9 | Catsper2 | Cation channel sperm-associated protein 2 | Mus musculus (Mouse) | PR |
| Q6QIY3 | Scn10a | Sodium channel protein type 10 subunit alpha | Mus musculus (Mouse) | PR |
| Q62205 | Scn9a | Sodium channel protein type 9 subunit alpha | Mus musculus (Mouse) | PR |
| Q9JJV9 | Scn5a | Sodium channel protein type 5 subunit alpha | Mus musculus (Mouse) | PR |
| Q9WTU3 | Scn8a | Sodium channel protein type 8 subunit alpha | Mus musculus (Mouse) | PR |
| O88457 | Scn11a | Sodium channel protein type 11 subunit alpha | Rattus norvegicus (Rat) | PR |
| Q62968 | Scn10a | Sodium channel protein type 10 subunit alpha | Rattus norvegicus (Rat) | PR |
| Q5QM84 | TPC1 | Two pore calcium channel protein 1 | Oryza sativa subsp japonica (Rice) | PR |
| Q94KI8 | TPC1 | Two pore calcium channel protein 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAARLLAPPG | PDSFKPFTPE | SLANIERRIA | ESKLKKPPKA | DGSHREDDED | SKPKPNSDLE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AGKSLPFIYG | DIPQGLVAVP | LEDFDPYYLT | QKTFVVLNRG | KTLFRFSATP | ALYILSPFNL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IRRIAIKILI | HSVFSMIIMC | TILTNCVFMT | FSNPPEWSKN | VEYTFTGIYT | FESLVKIIAR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GFCIDGFTFL | RDPWNWLDFS | VIMMAYVTEF | VDLGNVSALR | TFRVLRALKT | ISVIPGLKTI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VGALIQSVKK | LSDVMILTVF | CLSVFALIGL | QLFMGNLRNK | CVVWPINFNE | SYLENGTRGF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DWEEYINNKT | NFYMVPGMLE | PLLCGNSSDA | GQCPEGFQCM | KAGRNPNYGY | TSFDTFSWAF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LALFRLMTQD | YWENLYQLTL | RAAGKTYMIF | FVLVIFVGSF | YLVNLILAVV | AMAYEEQNQA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TLEEAEQKEA | EFKAMLEQLK | KQQEEAQAAA | MATSAGTVSE | DAIEEEGEDG | VGSPRSSSEL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SKLSSKSAKE | RRNRRKKRKQ | KELSEGEEKG | DPEKVFKSES | EDGMRRKAFR | LPDNRIGRKF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SIMNQSLLSI | PGSPFLSRHN | SKSSIFSFRG | PGRFRDPGSE | NEFADDEHST | VEESEGRRDS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LFIPIRARER | RSSYSGYSGY | SQCSRSSRIF | PSLRRSVKRN | STVDCNGVVS | LIGPGSHIGR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LLPEATTEVE | IKKKGPGSLL | VSMDQLASYG | RKDRINSIMS | VVTNTLVEEL | EESQRKCPPC |
| 730 | 740 | 750 | 760 | 770 | 780 |
| WYKFANTFLI | WECHPYWIKL | KEIVNLIVMD | PFVDLAITIC | IVLNTLFMAM | EHHPMTPQFE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| HVLAVGNLVF | TGIFTAEMFL | KLIAMDPYYY | FQEGWNIFDG | FIVSLSLMEL | SLADVEGLSV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LRSFRLLRVF | KLAKSWPTLN | MLIKIIGNSV | GALGNLTLVL | AIIVFIFAVV | GMQLFGKSYK |
| 910 | 920 | 930 | 940 | 950 | 960 |
| ECVCKINQEC | KLPRWHMNDF | FHSFLIVFRV | LCGEWIETMW | DCMEVAGQAM | CLIVFMMVMV |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| IGNLVVLNLF | LALLLSSFSA | DNLAATDDDG | EMNNLQISVI | RIKKGVAWTK | VKVHAFMQAH |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| FKQREADEVK | PLDELYEKKA | NCIANHTGVD | IHRNGDFQKN | GNGTTSGIGS | SVEKYIIDED |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| HMSFINNPNL | TVRVPIAVGE | SDFENLNTED | VSSESDPEGS | KDKLDDTSSS | EGSTIDIKPE |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| VEEVPVEQPE | EYLDPDACFT | EGCVQRFKCC | QVNIEEGLGK | SWWILRKTCF | LIVEHNWFET |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| FIIFMILLSS | GALAFEDIYI | EQRKTIRTIL | EYADKVFTYI | FILEMLLKWT | AYGFVKFFTN |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| AWCWLDFLIV | AVSLVSLIAN | ALGYSELGAI | KSLRTLRALR | PLRALSRFEG | MRVVVNALVG |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| AIPSIMNVLL | VCLIFWLIFS | IMGVNLFAGK | YHYCFNETSE | IRFEIDIVNN | KTDCEKLMEG |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| NSTEIRWKNV | KINFDNVGAG | YLALLQVATF | KGWMDIMYAA | VDSRKPDEQP | DYEGNIYMYI |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| YFVIFIIFGS | FFTLNLFIGV | IIDNFNQQKK | KFGGQDIFMT | EEQKKYYNAM | KKLGSKKPQK |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| PIPRPLNKIQ | GIVFDFVTQQ | AFDIVIMMLI | CLNMVTMMVE | TDTQSKQMEN | ILYWINLVFV |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| IFFTCECVLK | MFALRHYYFT | IGWNIFDFVV | VILSIVGMFL | ADIIEKYFVS | PTLFRVIRLA |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| RIGRILRLIK | GAKGIRTLLF | ALMMSLPALF | NIGLLLFLVM | FIFSIFGMSN | FAYVKHEAGI |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| DDMFNFETFG | NSMICLFQIT | TSAGWDGLLL | PILNRPPDCS | LDKEHPGSGF | KGDCGNPSVG |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| IFFFVSYIII | SFLIVVNMYI | AIILENFSVA | TEESADPLSE | DDFETFYEIW | EKFDPDATQF |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| IEYCKLADFA | DALEHPLRVP | KPNTIELIAM | DLPMVSGDRI | HCLDILFAFT | KRVLGDSGEL |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| DILRQQMEER | FVASNPSKVS | YEPITTTLRR | KQEEVSAVVL | QRAYRGHLAR | RGFICRKMAS |
| 1930 | 1940 | 1950 | 1960 | 1970 | |
| NKLENGGTHR | DKKESTPSTA | SLPSYDSVTK | PDKEKQQRAE | EGRRERAKRQ | KEVRESKC |