Q95RW8
Gene name |
Optix (opt, Six3, CG18455) |
Protein name |
Protein Optix |
Names |
Homeobox protein SIX3, D-Six3 |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG18455 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q95RW8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q95RW8-F1 | Predicted | AlphaFoldDB |
No variants for Q95RW8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q95RW8 | |||||
No associated diseases with Q95RW8
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| transcription regulator complex | A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| compound eye development | The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye. |
| compound eye morphogenesis | The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster. |
| compound eye photoreceptor cell differentiation | The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell. |
| dendrite morphogenesis | The process in which the anatomical structures of a dendrite are generated and organized. |
| progression of morphogenetic furrow involved in compound eye morphogenesis | The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O42406 | SIX3 | Homeobox protein SIX3 | Gallus gallus (Chicken) | PR |
| O93307 | SIX6 | Homeobox protein SIX6 | Gallus gallus (Chicken) | PR |
| Q15475 | SIX1 | Homeobox protein SIX1 | Homo sapiens (Human) | PR |
| Q9NPC8 | SIX2 | Homeobox protein SIX2 | Homo sapiens (Human) | PR |
| O95343 | SIX3 | Homeobox protein SIX3 | Homo sapiens (Human) | PR |
| O95475 | SIX6 | Homeobox protein SIX6 | Homo sapiens (Human) | PR |
| Q62231 | Six1 | Homeobox protein SIX1 | Mus musculus (Mouse) | PR |
| Q62232 | Six2 | Homeobox protein SIX2 | Mus musculus (Mouse) | PR |
| Q62233 | Six3 | Homeobox protein SIX3 | Mus musculus (Mouse) | PR |
| Q9QZ28 | Six6 | Homeobox protein SIX6 | Mus musculus (Mouse) | PR |
| Q94165 | ceh-34 | Homeobox protein ceh-34 | Caenorhabditis elegans | PR |
| Q6DHF9 | six1a | Homeobox protein six1a | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q6NZ04 | six1b | Homeobox protein six1b | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAVGPTEGKQ | PPSESFSPTH | HQIIAPSPIL | AVPTLAFSAA | QVEIVCKTLE | DSGDIERLAR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FLWSLPVALP | NMHEILNCEA | VLRARAVVAY | HVGNFRELYA | IIENHKFTKA | SYGKLQAMWL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EAHYIEAEKL | RGRSLGPVDK | YRVRKKFPLP | PTIWDGEQKT | HCFKERTRSL | LREWYLQDPY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PNPTKKRELA | KATGLNPTQV | GNWFKNRRQR | DRAAAAKNRI | QHSQNSSGMG | CRSRRADGAA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SPTPSDSSDS | DISLGTHSPV | PSSLQLQHSP | GSTSNGANDR | EESLSVDDDK | PRDLSGSLPL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PLSLPLPLAS | PTHTPPQLPP | GYGGGAGAGP | GGPLTGPGCL | PPFKLDAATS | LFSAGCYLQS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FSNLKEMSQQ | FPIQPIVLRP | HPQLPQSLAL | NGASGGPPLH | HPAYAAAYSV | ECVPGGHGPP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HPPPKLRINS | PEKLNSTAVA | AAASVGGGGG | NQHHEPTTTG | YHHSGQLMLH | RPFSTSPELK |
| HSAPEIT |