Q9QZ28

PR
Gene name
Six6 (Optx2, Six9)
Protein name
Homeobox protein SIX6
Names
Optic homeobox 2, Sine oculis homeobox homolog 6, Six9 protein
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:20476
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

67-246 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9QZ28

Entry ID Method Resolution Chain Position Source
AF-Q9QZ28-F1 Predicted AlphaFoldDB

16 variants for Q9QZ28

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389175837 12 Q>H No EVA
rs3389246254 49 K>R No EVA
rs3403551359 59 I>T No EVA
rs3403531112 62 F>L No EVA
rs3389235976 66 N>I No EVA
rs3389228578 86 K>* No EVA
rs3389228578 86 K>E No EVA
rs3389239885 92 L>P No EVA
rs3389228633 101 K>M No EVA
rs3389243910 111 D>Y No EVA
rs3389217152 114 R>Q No EVA
rs3403407904 128 G>D No EVA
rs3403343819 144 R>Q No EVA
rs3403746857 193 Q>H No EVA
rs255862492 214 E>V No EVA
rs3389235989 238 T>I No EVA

No associated diseases with Q9QZ28

3 regional properties for Q9QZ28

Type Name Position InterPro Accession
domain Homeobox domain 122 - 186 IPR001356
conserved_site Homeobox, conserved site 157 - 180 IPR017970
domain Homeobox protein SIX1, N-terminal SD domain 9 - 119 IPR031701

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription regulator complex A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

3 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific double-stranded DNA binding Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

2 GO annotations of biological process

Name Definition
eye development The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O93307 SIX6 Homeobox protein SIX6 Gallus gallus (Chicken) PR
Q95RW8 Optix Protein Optix Drosophila melanogaster (Fruit fly) PR
Q15475 SIX1 Homeobox protein SIX1 Homo sapiens (Human) PR
O95343 SIX3 Homeobox protein SIX3 Homo sapiens (Human) PR
Q9NPC8 SIX2 Homeobox protein SIX2 Homo sapiens (Human) PR
O95475 SIX6 Homeobox protein SIX6 Homo sapiens (Human) PR
Q62231 Six1 Homeobox protein SIX1 Mus musculus (Mouse) PR
Q62232 Six2 Homeobox protein SIX2 Mus musculus (Mouse) PR
Q62233 Six3 Homeobox protein SIX3 Mus musculus (Mouse) PR
Q94165 ceh-34 Homeobox protein ceh-34 Caenorhabditis elegans PR
Q6NZ04 six1b Homeobox protein six1b Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q6DHF9 six1a Homeobox protein six1a Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MFQLPILNFS PQQVAGVCET LEESGDVERL GRFLWSLPVA PAACEALNKN ESVLRARAIV
70 80 90 100 110 120
AFHGGNYREL YHILENHKFT KESHAKLQAL WLEAHYQEAE KLRGRPLGPV DKYRVRKKFP
130 140 150 160 170 180
LPRTIWDGEQ KTHCFKERTR HLLREWYLQD PYPNPSKKRE LAQATGLTPT QVGNWFKNRR
190 200 210 220 230 240
QRDRAAAAKN RLQQQVLSQG PGRVLRSEGE GTPEVLGVAS SPAASLSSKA ATSAISITSS
DSECDI