Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q62232

Entry ID Method Resolution Chain Position Source
AF-Q62232-F1 Predicted AlphaFoldDB

6 variants for Q62232

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3407461710 158 A>V No EVA
rs3408447374 161 T>A No EVA
rs3408102452 161 T>S No EVA
rs3389478903 188 E>G No EVA
rs3389495125 262 V>I No EVA
rs248086077 269 G>S No EVA

No associated diseases with Q62232

2 regional properties for Q62232

Type Name Position InterPro Accession
domain Homeobox domain 126 - 190 IPR001356
domain Homeobox protein SIX1, N-terminal SD domain 9 - 123 IPR031701

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription regulator complex A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

8 GO annotations of molecular function

Name Definition
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
protein-containing complex binding Binding to a macromolecular complex.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
sequence-specific double-stranded DNA binding Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.
transcription factor binding Binding to a transcription factor, a protein required to initiate or regulate transcription.

27 GO annotations of biological process

Name Definition
anterior/posterior axis specification The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cell population proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population.
chondrocyte differentiation The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.
condensed mesenchymal cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a condensed mesenchymal cell population. A condensed mesenchymal cell population is a population of adherent mesenchymal cells.
embryonic cranial skeleton morphogenesis The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase.
embryonic digestive tract morphogenesis The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed.
embryonic skeletal system morphogenesis The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase.
epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
kidney development The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
mesenchymal cell differentiation involved in kidney development The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the kidney as it progresses from its formation to the mature state.
mesenchymal stem cell maintenance involved in nephron morphogenesis The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells.
mesenchymal stem cell proliferation The multiplication or reproduction of mesenchymal stem cells, resulting in the expansion of a stem cell population. A mesenchymal stem cell, or MSC, is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells.
mesenchymal to epithelial transition involved in metanephros morphogenesis A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.
mesodermal cell fate specification The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
metanephros development The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.
middle ear morphogenesis The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window).
negative regulation of epithelial cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation.
nephron development The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney.
nephron morphogenesis The process in which the anatomical structures of the nephron are generated and organized. A nephron is the functional unit of the kidney.
positive regulation of chondrocyte proliferation Any process that increases the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus.
regulation of branching involved in ureteric bud morphogenesis Any process that modulates the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.
regulation of chondrocyte differentiation Any process that modulates the frequency, rate or extent of chondrocyte differentiation.
regulation of ossification Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O93307 SIX6 Homeobox protein SIX6 Gallus gallus (Chicken) PR
Q95RW8 Optix Protein Optix Drosophila melanogaster (Fruit fly) PR
Q15475 SIX1 Homeobox protein SIX1 Homo sapiens (Human) PR
O95343 SIX3 Homeobox protein SIX3 Homo sapiens (Human) PR
O95475 SIX6 Homeobox protein SIX6 Homo sapiens (Human) PR
Q9NPC8 SIX2 Homeobox protein SIX2 Homo sapiens (Human) PR
Q62231 Six1 Homeobox protein SIX1 Mus musculus (Mouse) PR
Q9QZ28 Six6 Homeobox protein SIX6 Mus musculus (Mouse) PR
Q62233 Six3 Homeobox protein SIX3 Mus musculus (Mouse) PR
Q94165 ceh-34 Homeobox protein ceh-34 Caenorhabditis elegans PR
Q6DHF9 six1a Homeobox protein six1a Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q6NZ04 six1b Homeobox protein six1b Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MSMLPTFGFT QEQVACVCEV LQQGGNIERL GRFLWSLPAC EHLHKNESVL KAKAVVAFHR
70 80 90 100 110 120
GNFRELYKIL ESHQFSPHNH AKLQQLWLKA HYIEAEKLRG RPLGAVGKYR VRRKFPLPRS
130 140 150 160 170 180
IWDGEETSYC FKEKSRSVLR EWYAHNPYPS PREKRELAEA TGLTTTQVSN WFKNRRQRDR
190 200 210 220 230 240
AAEAKERENS ENSNSSSHNP LASSLNGSGK SVLGSSEDEK TPSGTPDHSS SSPALLLSPP
250 260 270 280 290
PPPGLPSLHS LGHPPGPSAV PVPVPGGGGA DPLQHHHSLQ DSILNPMSAN LVDLGS