O93307
Gene name |
SIX6 (OPTX2, SIX9) |
Protein name |
Homeobox protein SIX6 |
Names |
Optic homeobox 2, Sine oculis homeobox homolog 6, Six9 protein |
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:395843 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O93307
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O93307-F1 | Predicted | AlphaFoldDB |
6 variants for O93307
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs737738749 | 52 | S>A | No | Ensembl | |
| rs737397101 | 83 | S>C | No | Ensembl | |
| rs732721511 | 84 | H>Q | No | Ensembl | |
| rs736524199 | 103 | R>L | No | Ensembl | |
| rs731880487 | 107 | L>W | No | Ensembl | |
| rs740738958 | 147 | Y>S | No | Ensembl |
No associated diseases with O93307
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| transcription regulator complex | A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| brain development | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| eye development | The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O42406 | SIX3 | Homeobox protein SIX3 | Gallus gallus (Chicken) | PR |
| Q95RW8 | Optix | Protein Optix | Drosophila melanogaster (Fruit fly) | PR |
| Q15475 | SIX1 | Homeobox protein SIX1 | Homo sapiens (Human) | PR |
| O95343 | SIX3 | Homeobox protein SIX3 | Homo sapiens (Human) | PR |
| Q9NPC8 | SIX2 | Homeobox protein SIX2 | Homo sapiens (Human) | PR |
| O95475 | SIX6 | Homeobox protein SIX6 | Homo sapiens (Human) | PR |
| Q62231 | Six1 | Homeobox protein SIX1 | Mus musculus (Mouse) | PR |
| Q62232 | Six2 | Homeobox protein SIX2 | Mus musculus (Mouse) | PR |
| Q62233 | Six3 | Homeobox protein SIX3 | Mus musculus (Mouse) | PR |
| Q9QZ28 | Six6 | Homeobox protein SIX6 | Mus musculus (Mouse) | PR |
| Q94165 | ceh-34 | Homeobox protein ceh-34 | Caenorhabditis elegans | PR |
| Q6NZ04 | six1b | Homeobox protein six1b | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q6DHF9 | six1a | Homeobox protein six1a | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFQLPILNFS | PQQVAGVCET | LEESGDIERL | GRFLWSLPVA | PAACEALNKN | ESVLRARAIV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AFHTGNYREL | YHILENHKFT | KESHGKLQAL | WLEAHYQEAE | KLRGRPLGPV | DKYRVRKKFP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LPRTIWDGEQ | KTHCFKERTR | HLLREWYLQD | PYPNPSKKRE | LAQATGLTPT | QVGNWFKNRR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QRDRAAAAKN | RLQQQVLAQG | SGRSLQAEEE | SGGEAGGAAS | SPAVSLSSKA | ATSAISITSS |
| DSECDI |