Q8VXG7
Gene name |
PAL1 |
Protein name |
Phenylalanine/tyrosine ammonia-lyase |
Names |
Bifunctional phenylalanine ammonia-lyase, Bifunctional PAL |
Species |
Zea mays (Maize) |
KEGG Pathway |
|
EC number |
4.3.1.25: Ammonia-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VXG7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VXG7-F1 | Predicted | AlphaFoldDB |
No variants for Q8VXG7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8VXG7 | |||||
No associated diseases with Q8VXG7
1 regional properties for Q8VXG7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| active_site | Phenylalanine/histidine ammonia-lyases, active site | 185 - 201 | IPR022313 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.3.1.25 | Ammonia-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ammonia-lyase activity | Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. |
| phenylalanine ammonia-lyase activity | Catalysis of the reaction: L-phenylalanine = NH(4)(+) + trans-cinnamate. |
| tyrosine ammonia-lyase activity | Catalysis of the reaction: L-tyrosine = NH(4)(+) + trans-4-coumarate. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cinnamic acid biosynthetic process | The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid. |
| L-phenylalanine catabolic process | The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. |
| phenylpropanoid biosynthetic process | The chemical reactions and pathways resulting in the formation of aromatic derivatives of trans-cinnamic acid. |
| protein arginylation | The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway. |
| response to cycloheximide | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes. |
| response to gibberellin | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P45735 | PAL | Phenylalanine ammonia-lyase | Vitis vinifera (Grape) | PR |
| P42357 | HAL | Histidine ammonia-lyase | Homo sapiens (Human) | PR |
| P35492 | Hal | Histidine ammonia-lyase | Mus musculus (Mouse) | PR |
| P31425 | PAL-1 | Phenylalanine ammonia-lyase 1 | Solanum tuberosum (Potato) | PR |
| P31426 | PAL-2 | Phenylalanine ammonia-lyase 2 | Solanum tuberosum (Potato) | PR |
| Q0DZE0 | ZB8 | Phenylalanine ammonia-lyase | Oryza sativa subsp japonica (Rice) | PR |
| P14717 | PAL | Phenylalanine ammonia-lyase | Oryza sativa subsp japonica (Rice) | PR |
| P26600 | PAL5 | Phenylalanine ammonia-lyase | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| P35511 | PAL | Phenylalanine ammonia-lyase | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGNGAIVES | DPLNWGAAAA | ELAGSHLDEV | KRMVAQARQP | VVKIEGSTLR | VGQVAAVASA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KDASGVAVEL | DEEARPRVKA | SSEWILDCIA | HGGDIYGVTT | GFGGTSHRRT | KDGPALQVEL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LRHLNAGIFG | TGSDGHTLPS | EVTRAAMLVR | INTLLQGYSG | IRFEILEAIT | KLLNTGVSPC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LPLRGTITAS | GDLVPLSYIA | GLITGRPNAQ | AVTVDGRKVD | AAEAFKIAGI | EGGFFKLNPK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EGLAIVNGTS | VGSALAATVM | YDANVLAVLS | EVLSAVFCEV | MNGKPEYTDH | LTHKLKHHPG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SIEAAAIMEH | ILDGSSFMKQ | AKKVNELDPL | LKPKQDRYAL | RTSPQWLGPQ | IEVIRAATKS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IEREVNSVND | NPVIDVHRGK | ALHGGNFQGT | PIGVSMDNAR | LAIANIGKLM | FAQFSELVNE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FYNNGLTSNL | AGSRNPSLDY | GFKGTEIAMA | SYCSELQYLG | NPITNHVQSA | DEHNQDVNSL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GLVSARKTAE | AIDILKLMSS | TYIVALCQAV | DLRHLEENIK | ASVKNTVTQV | AKKVLTMNPS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GELSSARFSE | KELISAIDRE | AVFTYAEDAA | SASLPLMQKL | RAVLVDHALS | SGERGAGALR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VLQDHQVRGG | APRGAAPGGG | GRPRGVAEGT | APVANRIADS | RSFPLYRFVR | EELGCVFLTG |
| 670 | 680 | 690 | 700 | ||
| ERLKSPGEEC | NKVFVGISQG | KLVDPMLECL | KEWDGKPLPI | NIK |