P35511

PR
Gene name
PAL
Protein name
Phenylalanine ammonia-lyase
Names
PAL
Species
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
KEGG Pathway
EC number
4.3.1.24: Ammonia-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

62-142 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P35511

Entry ID Method Resolution Chain Position Source
AF-P35511-F1 Predicted AlphaFoldDB

No variants for P35511

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P35511

No associated diseases with P35511

1 regional properties for P35511

Type Name Position InterPro Accession
active_site Phenylalanine/histidine ammonia-lyases, active site 186 - 202 IPR022313

Functions

Description
EC Number 4.3.1.24 Ammonia-lyases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

2 GO annotations of molecular function

Name Definition
ammonia-lyase activity Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate.
phenylalanine ammonia-lyase activity Catalysis of the reaction: L-phenylalanine = NH(4)(+) + trans-cinnamate.

2 GO annotations of biological process

Name Definition
cinnamic acid biosynthetic process The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid.
L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P42357 HAL Histidine ammonia-lyase Homo sapiens (Human) PR
Q8VXG7 PAL1 Phenylalanine/tyrosine ammonia-lyase Zea mays (Maize) PR
P35492 Hal Histidine ammonia-lyase Mus musculus (Mouse) PR
P31426 PAL-2 Phenylalanine ammonia-lyase 2 Solanum tuberosum (Potato) PR
P31425 PAL-1 Phenylalanine ammonia-lyase 1 Solanum tuberosum (Potato) PR
Q0DZE0 ZB8 Phenylalanine ammonia-lyase Oryza sativa subsp japonica (Rice) PR
P14717 PAL Phenylalanine ammonia-lyase Oryza sativa subsp japonica (Rice) PR
P26600 PAL5 Phenylalanine ammonia-lyase Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MDLCKKSIND PLNWEMAADS LRGSHLDEVK KMVDEFRKPI VKLGGETLSV AQVASIANVD
70 80 90 100 110 120
DKSNGVKVEL SESARAGVKA SSDWVMDSMS KGTDSYGVTA GFGATSHRRT KNGGALQKEL
130 140 150 160 170 180
IRFLNAGVFG NGIESFHTLP HSATRAAMLV RINTLLQGYS GIRFEILEAI TKLINSNITP
190 200 210 220 230 240
CLPLRGTITA SGDLVPLSYI AGLLTGRPNS KAVGPNGEKL NAEEAFCVAG ISGGFFELQP
250 260 270 280 290 300
KEGLALVNGT AVGSAMASIV LFESNIFAVM SEVLSAIFTE VMNGKPEFTD YLTHKLKHHP
310 320 330 340 350 360
GQIEAAAIME HILDGSSYVK VAQKLHEMDP LQKPKQDRYA LRTSPQWLGP QIEVIRAATK
370 380 390 400 410 420
MIEREINSVN DNPLIDVSRN KALHGGNFQG TPIGVSMDNT RLALASIGKL MFAQFSELVN
430 440 450 460 470 480
DYYNNGLPSN LTAGRNPSLD YGFKGAEIAM ASYCSELQFL ANPVTNHVQS AEQHNQDVNS
490 500 510 520 530 540
LGLISARKTA KAVDILKIMS STYLVALCQA IDLRHLEENL KSVVKNTVSQ VAKRTLTMGA
550 560 570 580 590 600
NGELHPARFS EKELLRVVDR EYLFAYADDP CSSNYPLMQK LRQVLVDQAM KNGESEKNVN
610 620 630 640 650 660
SSIFQKIGAF EDELIAVLPK EVESVRAVFE SGNPLIRNRI TECRSYPLYR LVREELGTEL
670 680 690 700
LTGEKVRSPG EEIDKVFTAI CNGQIIDPLL ECLKSWNGAP LPIC