P35492
Gene name |
Hal (Hsd, Huth) |
Protein name |
Histidine ammonia-lyase |
Names |
Histidase |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:15109 |
EC number |
4.3.1.3: Ammonia-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P35492
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P35492-F1 | Predicted | AlphaFoldDB |
20 variants for P35492
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389121162 | 3 | R>T | No | EVA | |
| rs3389122969 | 5 | T>I | No | EVA | |
| rs3389128832 | 29 | R>C | No | EVA | |
| rs3389121106 | 37 | K>Q | No | EVA | |
| rs36676660 | 46 | T>S | No | EVA | |
| rs3389090257 | 79 | F>V | No | EVA | |
| rs3389135061 | 81 | E>V | No | EVA | |
| rs3389097259 | 101 | V>I | No | EVA | |
| rs3389097296 | 149 | S>T | No | EVA | |
| rs3389121119 | 264 | A>T | No | EVA | |
| rs3389135080 | 272 | K>M | No | EVA | |
| rs3401392367 | 318 | E>Q | No | EVA | |
| rs3401573655 | 320 | L>Q | No | EVA | |
| 322 | R>Q | His; reduced stability [UniProt] | No | ||
| rs3389090234 | 367 | R>Q | No | EVA | |
| rs3389128842 | 411 | I>T | No | EVA | |
| rs3389125596 | 429 | P>T | No | EVA | |
| rs242642918 | 586 | V>I | No | EVA | |
| rs3401497155 | 590 | W>R | No | EVA | |
| rs253254185 | 617 | A>S | No | EVA |
1 associated diseases with P35492
Without disease ID
1 regional properties for P35492
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| active_site | Phenylalanine/histidine ammonia-lyases, active site | 185 - 201 | IPR022313 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.3.1.3 | Ammonia-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ammonia-lyase activity | Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. |
| histidine ammonia-lyase activity | Catalysis of the reaction: L-histidine = urocanate + NH3. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| histidine catabolic process | The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. |
| histidine catabolic process to glutamate and formamide | The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formamide. |
| histidine catabolic process to glutamate and formate | The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formate. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P45735 | PAL | Phenylalanine ammonia-lyase | Vitis vinifera (Grape) | PR |
| P42357 | HAL | Histidine ammonia-lyase | Homo sapiens (Human) | PR |
| Q8VXG7 | PAL1 | Phenylalanine/tyrosine ammonia-lyase | Zea mays (Maize) | PR |
| P31425 | PAL-1 | Phenylalanine ammonia-lyase 1 | Solanum tuberosum (Potato) | PR |
| P31426 | PAL-2 | Phenylalanine ammonia-lyase 2 | Solanum tuberosum (Potato) | PR |
| P14717 | PAL | Phenylalanine ammonia-lyase | Oryza sativa subsp japonica (Rice) | PR |
| Q0DZE0 | ZB8 | Phenylalanine ammonia-lyase | Oryza sativa subsp japonica (Rice) | PR |
| P26600 | PAL5 | Phenylalanine ammonia-lyase | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| P35511 | PAL | Phenylalanine ammonia-lyase | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPRYTVHVRG | EWLAVPCQDG | KLTVGWLGRE | AVRRYMKNKP | DNGGFTSVDE | VQFLVHRCKG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LGLLDNEDEL | EVALEDNEFV | EVVIEGDVMS | PDFIPSQPEG | VFLYSKYREP | EKYIALDGDS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LSTEDLVNLG | KGRYKIKLTS | IAEKKVQQSR | EVIDSIIKER | TVVYGITTGF | GKFARTVIPA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NKLQELQVNL | VRSHSSGVGK | PLSPERCRML | LALRINVLAK | GYSGISLETL | KQVIEAFNAS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CLSYVPEKGT | VGASGDLAPL | SHLALGLIGE | GKMWSPKSGW | ADAKYVLEAH | GLKPIVLKPK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EGLALINGTQ | MITSLGCEAL | ERASAIARQA | DIVAALTLEV | LKGTTKAFDT | DIHAVRPHRG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QIEVAFRFRS | LLDSDHHPSE | IAESHRFCDR | VQDAYTLRCC | PQVHGVVNDT | IAFVKDIITT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ELNSATDNPM | VFASRGETIS | GGNFHGEYPA | KALDYLAIGV | HELAAISERR | IERLCNPSLS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ELPAFLVAEG | GLNSGFMIAH | CTAAALVSES | KALCHPSSVD | SLSTSAATED | HVSMGGWAAR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KALRVVEHVE | QVLAIELLAA | CQGIEFLRPL | KTTTPLEKVY | DLVRSVVRPW | IKDRFMAPDI |
| 610 | 620 | 630 | 640 | 650 | |
| EAAHRLLLDQ | KVWEVAAPYI | EKYRMEHIPE | SRPLSPTAFS | LESLRKNSAT | IPESDDL |