P26600

PR
Gene name
PAL5
Protein name
Phenylalanine ammonia-lyase
Names
PAL
Species
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
KEGG Pathway
EC number
4.3.1.24: Ammonia-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

43-157 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P26600

Entry ID Method Resolution Chain Position Source
AF-P26600-F1 Predicted AlphaFoldDB

No variants for P26600

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P26600

No associated diseases with P26600

1 regional properties for P26600

Type Name Position InterPro Accession
active_site Phenylalanine/histidine ammonia-lyases, active site 203 - 219 IPR022313

Functions

Description
EC Number 4.3.1.24 Ammonia-lyases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

2 GO annotations of molecular function

Name Definition
ammonia-lyase activity Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate.
phenylalanine ammonia-lyase activity Catalysis of the reaction: L-phenylalanine = NH(4)(+) + trans-cinnamate.

2 GO annotations of biological process

Name Definition
cinnamic acid biosynthetic process The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid.
L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P45735 PAL Phenylalanine ammonia-lyase Vitis vinifera (Grape) PR
P42357 HAL Histidine ammonia-lyase Homo sapiens (Human) PR
Q8VXG7 PAL1 Phenylalanine/tyrosine ammonia-lyase Zea mays (Maize) PR
P35492 Hal Histidine ammonia-lyase Mus musculus (Mouse) PR
P31425 PAL-1 Phenylalanine ammonia-lyase 1 Solanum tuberosum (Potato) PR
P14717 PAL Phenylalanine ammonia-lyase Oryza sativa subsp japonica (Rice) PR
Q0DZE0 ZB8 Phenylalanine ammonia-lyase Oryza sativa subsp japonica (Rice) PR
P35511 PAL Phenylalanine ammonia-lyase Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MASSIVQNGH VNGEAMDLCK KSINVNDPLN WEMAAESLRG SHLDEVKKMV DEFRKPIVKL
70 80 90 100 110 120
GGETLTVAQV ASIANVDNKS NGVKVELSES ARAGVKASSD WVMDSMGKGT DSYGVTTGFG
130 140 150 160 170 180
ATSHRRTKNG GALQKELIRF LNAGVFGNGT ESSHTLPHSA TRAAMLVRIN TLLQGYSGIR
190 200 210 220 230 240
FEILEAITKL INSNITPCLP LRGTITASGD LVPLSYIAGL LTGRPNSKAV GPNGEKLNAE
250 260 270 280 290 300
ERFRVAGVTS GFFELQPKEG LALVNGTAVG SGMASMVLFE SNILAVMSEV LSAIFAEVMN
310 320 330 340 350 360
GKPEFTDYLT HKLKHHPGQI EAAAIMEHIL DGSSYVKAAQ KLHEMDPLQK PKQDRYALRT
370 380 390 400 410 420
SPQWLGPQIE VIRAATKMIE REINSVNDNP LIDVSRNKAL HGGNFQGTPI GVSMDNTRLA
430 440 450 460 470 480
LASIGKLMFA QFSELVNDYY NNGLPLNLTA GRNPSLDYGL KGAEIAMASY CSELQFLANP
490 500 510 520 530 540
VTNHVQSAEQ HNQDVNSLGL ISARKTAEAV DILKLMSSTY LVALCQAIDL RHLEENLKNA
550 560 570 580 590 600
VKNTVSQVAK KTLAMGANGE LHPARFCEKE LLQVVEREYL FTYADDPCSS TYPLMQKLRQ
610 620 630 640 650 660
VLVDHAMKNG ESEKNLNSSI FQKIVAFEDE LKAVLPKEVE SARAVVESGN PAIPNRITEC
670 680 690 700 710 720
RSYPLYRLVR QEVGTELLTG EKVRSPGEEI DKVFTAFCNG QIIDPLLECL KSWNGAPIPI
C