Q8S397
Gene name |
NHX4 (At5g55470, MTE17.18) |
Protein name |
Sodium/hydrogen exchanger 4 |
Names |
Na(+)/H(+) exchanger 4, NHE-4 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G55470 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8S397
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8S397-F1 | Predicted | AlphaFoldDB |
14 variants for Q8S397
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH03434549 | 8 | F>C | No | 1000Genomes | |
| ENSVATH14633819 | 32 | L>V | No | 1000Genomes | |
| ENSVATH07425742 | 36 | I>V | No | 1000Genomes | |
| ENSVATH00735749 | 58 | A>V | No | 1000Genomes | |
| tmp_5_22471839_T_G | 144 | R>S | No | 1000Genomes | |
| ENSVATH07425719 | 172 | L>M | No | 1000Genomes | |
| ENSVATH12783728 | 258 | A>S | No | 1000Genomes | |
| ENSVATH03434486 | 336 | G>V | No | 1000Genomes | |
| ENSVATH03434483 | 351 | L>I | No | 1000Genomes | |
| ENSVATH12783696 | 366 | F>C | No | 1000Genomes | |
| ENSVATH00735733 | 420 | T>N | No | 1000Genomes | |
| ENSVATH07425702 | 421 | N>I | No | 1000Genomes | |
| tmp_5_22469828_G_C | 439 | P>A | No | 1000Genomes | |
| tmp_5_22469767_C_T | 459 | R>H | No | 1000Genomes |
No associated diseases with Q8S397
1 regional properties for Q8S397
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cation/H+ exchanger | 25 - 442 | IPR006153 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| vacuolar membrane | The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| potassium:proton antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in). |
| sodium ion transmembrane transporter activity | Enables the transfer of sodium ions (Na+) from one side of a membrane to the other. |
| sodium:proton antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| potassium ion homeostasis | Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell. |
| potassium ion transmembrane transport | A process in which a potassium ion is transported from one side of a membrane to the other. |
| regulation of intracellular pH | Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion. |
| sodium ion import across plasma membrane | The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q28036 | SLC9A1 | Sodium/hydrogen exchanger 1 | Bos taurus (Bovine) | PR |
| Q4G0N8 | SLC9C1 | Sodium/hydrogen exchanger 10 | Homo sapiens (Human) | PR |
| Q9UBY0 | SLC9A2 | Sodium/hydrogen exchanger 2 | Homo sapiens (Human) | PR |
| Q14940 | SLC9A5 | Sodium/hydrogen exchanger 5 | Homo sapiens (Human) | PR |
| P19634 | SLC9A1 | Sodium/hydrogen exchanger 1 | Homo sapiens (Human) | PR |
| Q8BUE1 | Slc9a4 | Sodium/hydrogen exchanger 4 | Mus musculus (Mouse) | PR |
| Q61165 | Slc9a1 | Sodium/hydrogen exchanger 1 | Mus musculus (Mouse) | PR |
| P48762 | SLC9A1 | Sodium/hydrogen exchanger 1 | Sus scrofa (Pig) | PR |
| P26431 | Slc9a1 | Sodium/hydrogen exchanger 1 | Rattus norvegicus (Rat) | PR |
| P26434 | Slc9a4 | Sodium/hydrogen exchanger 4 | Rattus norvegicus (Rat) | PR |
| P48763 | Slc9a2 | Sodium/hydrogen exchanger 2 | Rattus norvegicus (Rat) | PR |
| Q8T5S1 | nhx-2 | Na(+)/H(+) exchanger protein 2 | Caenorhabditis elegans | PR |
| Q84WG1 | NHX3 | Sodium/hydrogen exchanger 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3YL57 | NHX8 | Sodium/hydrogen exchanger 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSIGLTEFVT | NKLAAEHPQV | IPISVFIAIL | CLCLVIGHLL | EENRWVNESI | TAILVGAASG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TVILLISKGK | SSHILVFDEE | LFFIYLLPPI | IFNAGFQVKK | KKFFHNFLTI | MSFGVIGVFI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| STVIISFGTW | WLFPKLGFKG | LSARDYLAIG | TIFSSTDTVC | TLQILHQDET | PLLYSLVFGE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GVVNDATSVV | LFNAVQKIQF | ESLTGWTALQ | VFGNFLYLFS | TSTLLGIGVG | LITSFVLKTL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YFGRHSTTRE | LAIMVLMAYL | SYMLAELFSL | SGILTVFFCG | VLMSHYASYN | VTESSRITSR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HVFAMLSFIA | ETFIFLYVGT | DALDFTKWKT | SSLSFGGTLG | VSGVITALVL | LGRAAFVFPL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SVLTNFMNRH | TERNESITFK | HQVIIWWAGL | MRGAVSIALA | FKQFTYSGVT | LDPVNAAMVT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NTTIVVLFTT | LVFGFLTKPL | VNYLLPQDAS | HNTGNRGKRT | EPGSPKEDAT | LPLLSFDESA |
| 490 | 500 | 510 | 520 | ||
| STNFNRAKDS | ISLLMEQPVY | TIHRYWRKFD | DTYMRPIFGG | PRRENQPEC |