AiPD: Autoinhibited Protein Database

Gene name	NHX3 (At3g06370, F24P17.16)
Protein name	Sodium/hydrogen exchanger 3
Names	Na(+)/H(+) exchanger 3, NHE-3
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT3G06370
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

427-503 (Predicted disordered autoinhibitory region) PR

427-503 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q84WG1-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH05783080	10	E>D	No	1000Genomes
ENSVATH05783079	17	A>T	No	1000Genomes
ENSVATH05783077	32	L>F	No	1000Genomes
tmp_3_1933154_A_G	94	I>T	No	1000Genomes
ENSVATH05783073	116	F>L	No	1000Genomes
tmp_3_1932834_T_A	146	I>F	No	1000Genomes
ENSVATH02118291	186	V>A	No	1000Genomes
tmp_3_1932543_C_T	186	V>M	No	1000Genomes
tmp_3_1932428_A_G	224	L>S	No	1000Genomes
ENSVATH13878219	231	A>T	No	1000Genomes
tmp_3_1932318_C_T	239	V>I	No	1000Genomes
tmp_3_1932195_G_C	249	S>C	No	1000Genomes
ENSVATH05783058	300	V>I	No	1000Genomes
tmp_3_1931826_T_G	315	I>L	No	1000Genomes
tmp_3_1931765_C_T	335	R>H	No	1000Genomes
ENSVATH05783047	380	L>*	No	1000Genomes
ENSVATH00309235	451	Q>R	No	1000Genomes
ENSVATH05783034	461	L>P	No	1000Genomes
ENSVATH05783033	462	R>G	No	1000Genomes
ENSVATH07954560	462	R>I	No	1000Genomes
ENSVATH07954559	466	H>Q	No	1000Genomes
ENSVATH07954558	469	I>L	No	1000Genomes
tmp_3_1931067_G_A	477	T>I	No	1000Genomes
tmp_3_1931034_T_G	488	H>P	No	1000Genomes
ENSVATH13878218	489	V>F	No	1000Genomes
ENSVATH09444654	490	S>N	No	1000Genomes
ENSVATH09444654	490	S>T	No	1000Genomes
ENSVATH09444653	491	F>L	No	1000Genomes
ENSVATH09444651	492	R>G	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Cation/H+ exchanger	30 - 443	IPR006153

		Description
EC Number
Subcellular Localization	Vacuole membrane ; Multi-pass membrane protein	Tonoplast
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plant-type vacuole	A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
vacuolar membrane	The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

Name	Definition
potassium:proton antiporter activity	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in).
sodium:proton antiporter activity	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).

Name	Definition
potassium ion transmembrane transport	A process in which a potassium ion is transported from one side of a membrane to the other.
regulation of intracellular pH	Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion.
response to salt stress	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
sodium ion import across plasma membrane	The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q28036	SLC9A1	Sodium/hydrogen exchanger 1	Bos taurus (Bovine)	PR
Q4G0N8	SLC9C1	Sodium/hydrogen exchanger 10	Homo sapiens (Human)	PR
Q9UBY0	SLC9A2	Sodium/hydrogen exchanger 2	Homo sapiens (Human)	PR
Q14940	SLC9A5	Sodium/hydrogen exchanger 5	Homo sapiens (Human)	PR
P19634	SLC9A1	Sodium/hydrogen exchanger 1	Homo sapiens (Human)	PR
Q8BUE1	Slc9a4	Sodium/hydrogen exchanger 4	Mus musculus (Mouse)	PR
Q61165	Slc9a1	Sodium/hydrogen exchanger 1	Mus musculus (Mouse)	PR
P48762	SLC9A1	Sodium/hydrogen exchanger 1	Sus scrofa (Pig)	PR
P26431	Slc9a1	Sodium/hydrogen exchanger 1	Rattus norvegicus (Rat)	PR
P26434	Slc9a4	Sodium/hydrogen exchanger 4	Rattus norvegicus (Rat)	PR
P48763	Slc9a2	Sodium/hydrogen exchanger 2	Rattus norvegicus (Rat)	PR
Q8T5S1	nhx-2	Na(+)/H(+) exchanger protein 2	Caenorhabditis elegans	PR
Q8S397	NHX4	Sodium/hydrogen exchanger 4	Arabidopsis thaliana (Mouse-ear cress)	PR
Q3YL57	NHX8	Sodium/hydrogen exchanger 8	Arabidopsis thaliana (Mouse-ear cress)	PR