P48762
PR
Gene name |
SLC9A1 (NHE1) |
Protein name |
Sodium/hydrogen exchanger 1 |
Names |
Na(+)/H(+) exchanger 1, NHE-1, Solute carrier family 9 member 1 |
Species |
Sus scrofa (Pig) |
KEGG Pathway |
ssc:397458 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P48762
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P48762-F1 | Predicted | AlphaFoldDB |
No variants for P48762
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P48762 | |||||
No associated diseases with P48762
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium-dependent protein binding | Binding to a protein or protein complex in the presence of calcium. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| sodium:proton antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to acidic pH | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution. |
| protein complex oligomerization | The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. |
| regulation of intracellular pH | Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion. |
| regulation of pH | Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. |
| response to acidic pH | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution. |
| sodium ion export across plasma membrane | The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q28036 | SLC9A1 | Sodium/hydrogen exchanger 1 | Bos taurus (Bovine) | PR |
| Q9UBY0 | SLC9A2 | Sodium/hydrogen exchanger 2 | Homo sapiens (Human) | PR |
| Q14940 | SLC9A5 | Sodium/hydrogen exchanger 5 | Homo sapiens (Human) | PR |
| P19634 | SLC9A1 | Sodium/hydrogen exchanger 1 | Homo sapiens (Human) | PR |
| Q8BUE1 | Slc9a4 | Sodium/hydrogen exchanger 4 | Mus musculus (Mouse) | PR |
| Q61165 | Slc9a1 | Sodium/hydrogen exchanger 1 | Mus musculus (Mouse) | PR |
| P48763 | Slc9a2 | Sodium/hydrogen exchanger 2 | Rattus norvegicus (Rat) | PR |
| P26434 | Slc9a4 | Sodium/hydrogen exchanger 4 | Rattus norvegicus (Rat) | PR |
| P26431 | Slc9a1 | Sodium/hydrogen exchanger 1 | Rattus norvegicus (Rat) | PR |
| Q8T5S1 | nhx-2 | Na(+)/H(+) exchanger protein 2 | Caenorhabditis elegans | PR |
| Q8S397 | NHX4 | Sodium/hydrogen exchanger 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84WG1 | NHX3 | Sodium/hydrogen exchanger 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLLWSGICGL | SPPRIFPSLL | VVVALVGLLP | VLRSHGLQPS | PTASTIRGSE | PPRERSIGDV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TTAPPELAPE | SRPVNHSVTE | HGMKARKAFP | VLGIDYTHVR | TPFEISLWIL | LACLMKIGFH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VIPTISSIVP | ESCLLIVVGL | LVGGLIKAVG | ETPPFLQSEV | FFLFLLPPII | LDAGYFLPLR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QFTENLGTIL | IFAVVGTLWN | AFFLGGLMYA | VCLVGGEQIN | NIGLLDNLLF | GSIISAVDPV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AVLAVFEEIH | INELLHILVF | GESLLNDAVT | VVLYHLFEEF | ANYDRVGIVD | IVLGFLSFFV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VSLGGVFVGV | VYGVIAAFTS | RFTSHIRVIE | PLFVFLYSYM | AYLSAELFHL | SGIMALIASG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VVMRPYVEAN | ISHKSHTTIK | YFLKMWSSVS | ETLIFIFLGV | STVAGSHHWN | WTFVISTLLF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CLIARVLGVL | GLTWFINKFR | IVKLTPKDQF | IIAYGGLRGA | IAFSLGHLLD | KNHFPMCDLF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LTAIITVIFF | TVFVQGMTIR | PLVDLLAVKK | KQETKRSINE | EIHTQFLDHL | LTGIEDICGH |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YGHHHWKDKL | NRFNKKYVKK | CLIAGERSKE | PQLIAFYHKM | EMKQAIELVE | SGGMGKIPSA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VSTVSMQNIH | PKTLPTERIL | PALSKDKEEE | IRKILRNNLQ | KTRQRLRSYN | RHTLVADPYE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EAWNQMLLRR | QKARQLEQKI | NNHLTVPAHK | LDSPTMSRAR | IGSDPLAYEP | KADLPVITID |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PASPQSPESV | DLVNEELKGK | VLGLSREPGR | ATEEEDDDED | HDGGLVMRTK | EPSSPGTDDV |
| 790 | 800 | 810 | |||
| FTPAPSDSPS | SQRIQRCLSD | PGPHPEPGEG | EPFIPKGQ |