Q8T5S1
PR
Gene name |
nhx-2 |
Protein name |
Na(+)/H(+) exchanger protein 2 |
Names |
Na(+)/H(+) antiporter nhx-2 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_B0495.4 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8T5S1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8T5S1-F1 | Predicted | AlphaFoldDB |
No variants for Q8T5S1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8T5S1 | |||||
No associated diseases with Q8T5S1
1 regional properties for Q8T5S1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cation/H+ exchanger | 52 - 454 | IPR006153 |
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| potassium:proton antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in). |
| sodium:proton antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| determination of adult lifespan | The pathways that regulate the duration of the adult phase of the life-cycle of an animal. |
| lipid storage | The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. |
| nematode larval development | The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. |
| positive regulation of fatty acid transport | Any process that activates or increases the frequency, rate or extent of fatty acid transport. |
| positive regulation of growth rate | Any process that increases the rate of growth of all or part of an organism. |
| positive regulation of multicellular organism growth | Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size. |
| potassium ion transmembrane transport | A process in which a potassium ion is transported from one side of a membrane to the other. |
| regulation of intracellular pH | Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion. |
| regulation of peptide transport | Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of pH | Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. |
| regulation of pharyngeal pumping | Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes. |
| reproduction | The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms. |
| sodium ion import across plasma membrane | The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q28036 | SLC9A1 | Sodium/hydrogen exchanger 1 | Bos taurus (Bovine) | PR |
| Q14940 | SLC9A5 | Sodium/hydrogen exchanger 5 | Homo sapiens (Human) | PR |
| Q9UBY0 | SLC9A2 | Sodium/hydrogen exchanger 2 | Homo sapiens (Human) | PR |
| P19634 | SLC9A1 | Sodium/hydrogen exchanger 1 | Homo sapiens (Human) | PR |
| Q61165 | Slc9a1 | Sodium/hydrogen exchanger 1 | Mus musculus (Mouse) | PR |
| Q8BUE1 | Slc9a4 | Sodium/hydrogen exchanger 4 | Mus musculus (Mouse) | PR |
| P48762 | SLC9A1 | Sodium/hydrogen exchanger 1 | Sus scrofa (Pig) | PR |
| P26431 | Slc9a1 | Sodium/hydrogen exchanger 1 | Rattus norvegicus (Rat) | PR |
| P26434 | Slc9a4 | Sodium/hydrogen exchanger 4 | Rattus norvegicus (Rat) | PR |
| P48763 | Slc9a2 | Sodium/hydrogen exchanger 2 | Rattus norvegicus (Rat) | PR |
| Q84WG1 | NHX3 | Sodium/hydrogen exchanger 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8S397 | NHX4 | Sodium/hydrogen exchanger 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSLLRRPWVL | VVGLLLIMSY | VGAECEEEEK | EYPSRYPIAY | FEWENVKIPM | TICLWLIGAS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IAKIIFNLIP | HLNELFPDSA | LLIMIGLIIG | IIFKLIGVNK | NAFFLESEVF | MLYLLPPLVF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DAGYFMPARQ | FFDNFGSILC | FAMIGTSFNI | VAIALSLWAI | SLTGLFSVET | PLMHMLLFGS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VAADVDPVAV | IVIFEELKVN | EVLFIAVFGE | SLLNDGVAVV | LYRMFLTFSE | IGTENLITSD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YINGGVSFLV | VAFGGIGIGL | LFAFLTSLVT | RFARDEEVKV | LNSVFILILP | YTCYLCGELF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GLSSIMAIVF | CGAAMRQYCR | ENVDPDTVKA | TESFIKVLSL | ASETVIFVFL | GLSTVSSNHH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| WDTSFIVLTV | VFCLIYRTLG | VVVMCYFLNK | YRLNKYTKVD | QFIMAYGGLR | GAIAYGLVVA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IPDFIPGKNM | FVTSCIIVIY | FTVFLQGITL | KPIAEFLQVE | KKNVHSKNMI | EHIYSELIDT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TMAGMEDIAG | FKGHHWIRDS | WNALNNNYLR | PILVNKNNMK | EMDKTKLVRK | YKHLVDEDAK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KIARGDLNSN | MVFTKALIEH | TRSRTNTMID | GVSSTSKIDF | TKHMKENFGV | TVYDDHSTVP |
| 610 | 620 | 630 | 640 | ||
| MTPTHLFQET | TEVEYSVRSE | INDNDGFEND | GYESDESGSF | HERV |