P26434
PR
Gene name |
Slc9a4 (Nhe4) |
Protein name |
Sodium/hydrogen exchanger 4 |
Names |
Na(+)/H(+) exchanger 4, NHE-4, Solute carrier family 9 member 4 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:24785 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P26434
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P26434-F1 | Predicted | AlphaFoldDB |
No variants for P26434
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P26434 | |||||
No associated diseases with P26434
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| vacuolar membrane | The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| potassium:proton antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in). |
| sodium:proton antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| epithelial cell development | The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. |
| gastric acid secretion | The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. |
| glandular epithelial cell development | The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. |
| potassium ion homeostasis | Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell. |
| potassium ion transmembrane transport | A process in which a potassium ion is transported from one side of a membrane to the other. |
| regulation of intracellular pH | Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion. |
| response to salt stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. |
| sodium ion import across plasma membrane | The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q28036 | SLC9A1 | Sodium/hydrogen exchanger 1 | Bos taurus (Bovine) | PR |
| Q9UBY0 | SLC9A2 | Sodium/hydrogen exchanger 2 | Homo sapiens (Human) | PR |
| P19634 | SLC9A1 | Sodium/hydrogen exchanger 1 | Homo sapiens (Human) | PR |
| Q14940 | SLC9A5 | Sodium/hydrogen exchanger 5 | Homo sapiens (Human) | PR |
| Q61165 | Slc9a1 | Sodium/hydrogen exchanger 1 | Mus musculus (Mouse) | PR |
| Q8BUE1 | Slc9a4 | Sodium/hydrogen exchanger 4 | Mus musculus (Mouse) | PR |
| P48762 | SLC9A1 | Sodium/hydrogen exchanger 1 | Sus scrofa (Pig) | PR |
| P26431 | Slc9a1 | Sodium/hydrogen exchanger 1 | Rattus norvegicus (Rat) | PR |
| P48763 | Slc9a2 | Sodium/hydrogen exchanger 2 | Rattus norvegicus (Rat) | PR |
| Q8T5S1 | nhx-2 | Na(+)/H(+) exchanger protein 2 | Caenorhabditis elegans | PR |
| Q8S397 | NHX4 | Sodium/hydrogen exchanger 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84WG1 | NHX3 | Sodium/hydrogen exchanger 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGPAMLRAFS | SWKWLLLLMV | LTCLEASSYV | NESSSPTGQQ | TPDARFAASS | SDPDERISVF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ELDYDYVQIP | YEVTLWILLA | SLAKIGFHLY | HRLPHLMPES | CLLIIVGALV | GSIIFGTHHK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SPPVMDSSIY | FLYLLPPIVL | ESGYFMPTRP | FFENIGSILW | WAGLGALINA | FGIGLSLYFI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CQIKAFGLGD | INLLQNLLFG | SLISAVDPVA | VLAVFEEARV | NEQLYMMIFG | EALLNDGISV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VLYNILIAFT | KMHKFEDIEA | VDILAGCARF | VIVGCGGVFF | GIIFGFISAF | ITRFTQNISA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IEPLIVFMFS | YLSYLAAETL | YLSGILAITA | CAVTMKKYVE | ENVSQTSYTT | IKYFMKMLSS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VSETLIFIFM | GVSTVGKNHE | WNWAFVCFTL | AFCQIWRAIS | VFTLFYVSNQ | FRTFPFSIKD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QLIIFYSGVR | GAGSFSLAFL | LPLTLFPRKK | LFVTATLVVT | YFTVFFQGIT | IGPLVRYLDV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RKTNKKESIN | EELHIRLMDH | LKAGIEDVCG | QWSHYQVRDK | FKKFDHRYLR | KILIRRNQPK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SSIVSLYKKL | EMKQAIEMAE | TGLLSSVASP | TPYQSERIQG | IKRLSPEDVE | SMRDILTRNM |
| 610 | 620 | 630 | 640 | 650 | 660 |
| YQVRQRTLSY | NKYNLKPQTS | EKQAKEILIR | RQNTLRESLR | KGQSLPWVKP | AGTKNFRYLS |
| 670 | 680 | 690 | 700 | 710 | |
| FPYSNPQPAR | RGARAAESTG | NPCCWLLHFL | LCRAMVEKIW | GPGGQETQPR | LLCRNLN |