P48763
Gene name |
Slc9a2 (Nhe2) |
Protein name |
Sodium/hydrogen exchanger 2 |
Names |
H7, Na(+)/H(+) exchanger 2, NHE-2, Solute carrier family 9 member 2 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:24783 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P48763
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P48763-F1 | Predicted | AlphaFoldDB |
No variants for P48763
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P48763 | |||||
No associated diseases with P48763
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| potassium:proton antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in). |
| sodium:proton antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| potassium ion transmembrane transport | A process in which a potassium ion is transported from one side of a membrane to the other. |
| protein localization | Any process in which a protein is transported to, or maintained in, a specific location. |
| proton transmembrane transport | The directed movement of a proton across a membrane. |
| regulation of intracellular pH | Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion. |
| regulation of pH | Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. |
| sodium ion import across plasma membrane | The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| sodium ion transport | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q28036 | SLC9A1 | Sodium/hydrogen exchanger 1 | Bos taurus (Bovine) | PR |
| P19634 | SLC9A1 | Sodium/hydrogen exchanger 1 | Homo sapiens (Human) | PR |
| Q14940 | SLC9A5 | Sodium/hydrogen exchanger 5 | Homo sapiens (Human) | PR |
| Q9UBY0 | SLC9A2 | Sodium/hydrogen exchanger 2 | Homo sapiens (Human) | PR |
| Q61165 | Slc9a1 | Sodium/hydrogen exchanger 1 | Mus musculus (Mouse) | PR |
| Q8BUE1 | Slc9a4 | Sodium/hydrogen exchanger 4 | Mus musculus (Mouse) | PR |
| P48762 | SLC9A1 | Sodium/hydrogen exchanger 1 | Sus scrofa (Pig) | PR |
| P26431 | Slc9a1 | Sodium/hydrogen exchanger 1 | Rattus norvegicus (Rat) | PR |
| P26434 | Slc9a4 | Sodium/hydrogen exchanger 4 | Rattus norvegicus (Rat) | PR |
| Q8T5S1 | nhx-2 | Na(+)/H(+) exchanger protein 2 | Caenorhabditis elegans | PR |
| Q8S397 | NHX4 | Sodium/hydrogen exchanger 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84WG1 | NHX3 | Sodium/hydrogen exchanger 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGPSGTAHRM | RAPLSWLLLL | LLSLQVAVPA | GALAETLLDA | PGARGASSNP | PSPASVVAPG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TTPFEESRLP | VFTLDYPHVQ | IPFEITLWIL | LASLAKIGFH | LYHKLPTIVP | ESCLLIMVGL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLGGIIFGVD | EKSPPAMKTD | VFFLYLLPPI | VLDAGYFMPT | RPFFENLGTI | FWYAVVGTLW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NSIGIGLSLF | GICQIEAFGL | SDITLLQNLL | FGSLISAVDP | VAVLAVFENI | HVNEQLYILV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FGESLLNDAV | TVVLYNLFKS | FCQMKTIQTV | DVFAGIANFF | VVGIGGVLIG | ILLGFIAAFT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TRFTHNIRVI | EPLFVFLYSY | LSYITAEMFH | LSGIMAITAC | AMTMNKYVEE | NVSQKSYTTI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KYFMKMLSSV | SETLIFIFMG | VSTVGKNHEW | NWAFVCFTLA | FCLIWRALGV | FVLTQVINWF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RTIPLTFKDQ | FIIAYGGLRG | AICFALVFLL | PATVFPRKKL | FITAAIVVIF | FTVFILGITI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RPLVEFLDVK | RSNKKQQAVS | EEIHCRFFDH | VKTGIEDVCG | HWGHNFWRDK | FKKFDDKYLR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KLLIRENQPK | SSIVSLYKKL | EIKHAIEMAE | TGMISTVPSF | ASLNDCREEK | IRKLTPGEMD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EIREILSRNL | YQIRQRTLSY | NRHNLTADTS | ERQAKEILIR | RRHSLRESLR | KDNSLNRERR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ASTSTSRYLS | LPKNTKLPEK | LQKKNKVSNA | DGNSSDSDMD | GTTVLNLQPR | ARRFLPDQFS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KKASPAYKME | WKNEVDVGSA | RAPPSVTPAP | RSKEGGTQTP | GVLRQPLLSK | DQRFGRGRED |
| 790 | 800 | 810 | |||
| SLTEDVPPKP | PPRLVRRASE | PGNRKGRLGN | EKP |