Q8BUE1

PR
Gene name
Slc9a4 (Nhe4)
Protein name
Sodium/hydrogen exchanger 4
Names
Na(+)/H(+) exchanger 4, NHE-4, Solute carrier family 9 member 4
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:110895
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

3-76 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BUE1

Entry ID Method Resolution Chain Position Source
AF-Q8BUE1-F1 Predicted AlphaFoldDB

76 variants for Q8BUE1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389831075 5 M>* No EVA
rs47520856 5 M>I No EVA
rs3388467604 12 W>* No EVA
rs3388465517 14 W>* No EVA
rs3388466887 21 L>I No EVA
rs233044169 23 R>C No EVA
rs3388467123 28 S>L No EVA
rs3388467027 92 R>W No EVA
rs3388466956 108 A>T No EVA
rs3389879709 115 F>C No EVA
rs3388466182 119 H>P No EVA
rs3388466410 120 K>Q No EVA
rs3388466718 138 I>N No EVA
rs3388466698 145 F>V No EVA
rs3388466865 165 G>R No EVA
rs3389852196 171 F>I No EVA
rs3389885664 171 F>L No EVA
rs3389888264 171 F>Y No EVA
rs3389888406 179 F>L No EVA
rs3389879779 186 F>I No EVA
rs3389852216 186 F>L No EVA
rs3389885668 186 F>Y No EVA
rs3388465543 203 I>F No EVA
rs3388467309 239 S>G No EVA
rs3388466587 259 E>G No EVA
rs241141608 260 A>V No EVA
rs3388466556 318 E>D No EVA
rs3388465886 339 V>M No EVA
rs3389888255 358 L>M No EVA
rs3389852218 358 L>Q No EVA
rs3388466564 359 S>I No EVA
rs3388466564 359 S>N No EVA
rs3389879798 360 S>R No EVA
rs3389878196 362 S>T No EVA
rs3412162656 363 E>D No EVA
rs3389897666 363 E>Q No EVA
rs3389866553 366 I>L No EVA
rs3389890470 376 G>F No EVA
rs3388466648 410 Q>P No EVA
rs3388465850 446 F>Y No EVA
rs3388466315 448 R>S No EVA
rs3388465824 485 K>E No EVA
rs3388466869 516 Q>R No EVA
rs3388467090 526 H>N No EVA
rs3388467257 529 L>S No EVA
rs232236140 536 R>K No EVA
rs3388466724 547 Y>* No EVA
rs3388467261 551 E>K No EVA
rs3388467109 554 Q>E No EVA
rs3389832015 557 E>D No EVA
rs49869871 575 S>P No EVA
rs3388467263 580 G>R No EVA
rs3388466274 584 L>H No EVA
rs3388466565 592 M>V No EVA
rs3388465829 600 M>R No EVA
rs3388467364 602 Q>L No EVA
rs246989786 668 A>G No EVA
rs228108626 676 A>V No EVA
rs256741452 678 P>S No EVA
rs241713380 695 I>L No EVA
rs241713380 695 I>V No EVA
rs226038701 711 V>M No EVA
rs242091926 720 G>R No EVA
rs230829392 729 R>Q No EVA
rs238856455 742 R>G No EVA
rs3388466928 757 E>K No EVA
rs3388466357 758 E>D No EVA
rs3388466401 761 S>A No EVA
rs3388467418 767 E>A No EVA
rs3389880395 775 R>I No EVA
rs3389879760 775 R>S No EVA
rs3389832000 778 A>V No EVA
rs248572294 783 S>T No EVA
rs217744364 784 T>R No EVA
rs249321403 786 H>Y No EVA
rs3388466417 790 H>D No EVA

No associated diseases with Q8BUE1

2 regional properties for Q8BUE1

Type Name Position InterPro Accession
domain Cation/H+ exchanger 74 - 476 IPR006153
domain Sodium/hydrogen exchanger, regulatory region 567 - 674 IPR032103

Functions

Description
EC Number
Subcellular Localization
  • Basolateral cell membrane ; Multi-pass membrane protein
  • Apical cell membrane ; Multi-pass membrane protein
  • Zymogen granule membrane ; Multi-pass membrane protein
  • Enrichment at apical or basolateral membrane may be tissue-dependent
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
vacuolar membrane The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

2 GO annotations of molecular function

Name Definition
potassium:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in).
sodium:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).

7 GO annotations of biological process

Name Definition
gastric acid secretion The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.
glandular epithelial cell development The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.
potassium ion homeostasis Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell.
potassium ion transmembrane transport A process in which a potassium ion is transported from one side of a membrane to the other.
regulation of intracellular pH Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion.
response to salt stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
sodium ion import across plasma membrane The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q28036 SLC9A1 Sodium/hydrogen exchanger 1 Bos taurus (Bovine) PR
P19634 SLC9A1 Sodium/hydrogen exchanger 1 Homo sapiens (Human) PR
Q14940 SLC9A5 Sodium/hydrogen exchanger 5 Homo sapiens (Human) PR
Q9UBY0 SLC9A2 Sodium/hydrogen exchanger 2 Homo sapiens (Human) PR
Q61165 Slc9a1 Sodium/hydrogen exchanger 1 Mus musculus (Mouse) PR
P48762 SLC9A1 Sodium/hydrogen exchanger 1 Sus scrofa (Pig) PR
P48763 Slc9a2 Sodium/hydrogen exchanger 2 Rattus norvegicus (Rat) PR
P26431 Slc9a1 Sodium/hydrogen exchanger 1 Rattus norvegicus (Rat) PR
P26434 Slc9a4 Sodium/hydrogen exchanger 4 Rattus norvegicus (Rat) PR
Q8T5S1 nhx-2 Na(+)/H(+) exchanger protein 2 Caenorhabditis elegans PR
Q84WG1 NHX3 Sodium/hydrogen exchanger 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q8S397 NHX4 Sodium/hydrogen exchanger 4 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGPAMFMAFR LWNWLLLLAV LTRSEATSYV NESSNPTAQQ APDARFAASS SDPDEGISVF
70 80 90 100 110 120
ELDYDYVQIP YEVTLWILLA SLAKIGFHLY HRLPHLMPES CLLIIVGALV GGIIFGTHHK
130 140 150 160 170 180
SPPVMDSSIY FLYLLPPIVL ESGYFMPTRP FFENIGSILW WAGLGALINA FGIGLSLYFI
190 200 210 220 230 240
CQIKAFGLGD INLLHNLLFG SLISAVDPVA VLAVFEEARV NEQLYMMIFG EALLNDGISV
250 260 270 280 290 300
VLYNILIAFT KMHKFEDIEA VDILAGCARF VIVGCGGVFF GIIFGFISAF ITRFTQNISA
310 320 330 340 350 360
IEPLIVFMFS YLSYLAAETL YLSGILAITA CAVTMKKYVE ENVSQTSYTT IKYFMKMLSS
370 380 390 400 410 420
VSETLIFIFM GVSTIGKNHE WNWAFICFTL LFCQIWRAIS VFTLFYVSNQ FRTFPFSIKD
430 440 450 460 470 480
QFIIFYSGVR GAGSFSLAFL LPLSLFPRKK LFVTATLVVT YFTVFFQGIT IGPLVRYLDV
490 500 510 520 530 540
RKTNKKESIN EELHSRLMDH LKAGIEDVCG QWSHYQVRDK FKKFDHRYLR KILIRRNLPK
550 560 570 580 590 600
SSIVSLYKKL EMKQAIEMVE TGILSSVASP TPYQSERIQG IKRLSPEDVE SMRDILTRSM
610 620 630 640 650 660
YQVRQRTLSY NKYNLKPQTS EKQAKEILIR RQNTLRESMR KGQSLPWGKP AGTKNFRYLS
670 680 690 700 710 720
FPYSNPQAAR REARAAEPTD DDGTDSGFQP LMFSIHSRAG SLQERRQTQA VIPMKRLQRG
730 740 750 760 770 780
EKALSFSYRS NTSWEDQAGW RRMDVLRPKP LFYAVAEEYD SGEQTEEETS AILSRWTAEH
790
RHSTEHHKSH SPLLHRK