Q3YL57

PR
Gene name
NHX8 (SOS1B, At1g14660, F10B6.1, T5E21.14)
Protein name
Sodium/hydrogen exchanger 8
Names
Na(+)/H(+) exchanger 8, NHE-8, Protein SALT OVERLY SENSITIVE 1B
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G14660
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3YL57

Entry ID Method Resolution Chain Position Source
AF-Q3YL57-F1 Predicted AlphaFoldDB

107 variants for Q3YL57

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH11218383 8 A>G No 1000Genomes
ENSVATH13897265 9 L>F No 1000Genomes
ENSVATH00023555 11 Y>C No 1000Genomes
ENSVATH11218382 14 P>S No 1000Genomes
ENSVATH00023553 17 A>E No 1000Genomes
ENSVATH11218380 21 S>F No 1000Genomes
ENSVATH11218381 21 S>T No 1000Genomes
tmp_1_5036340_C_A 34 A>S No 1000Genomes
ENSVATH11218379 38 A>P No 1000Genomes
ENSVATH04577227 46 T>S No 1000Genomes
ENSVATH00023551 50 Y>H No 1000Genomes
ENSVATH00023550 56 R>K No 1000Genomes
ENSVATH00023549 69 F>V No 1000Genomes
tmp_1_5036223_G_C 73 L>V No 1000Genomes
ENSVATH01051388 78 K>M No 1000Genomes
tmp_1_5035996_T_A 94 I>F No 1000Genomes
tmp_1_5035932_A_G 115 M>T No 1000Genomes
tmp_1_5035836_C_A 122 R>I No 1000Genomes
ENSVATH00023546 141 C>Y No 1000Genomes
tmp_1_5035760_C_G 147 K>N No 1000Genomes
ENSVATH04577216 158 T>I No 1000Genomes
ENSVATH04577215 159 S>T No 1000Genomes
tmp_1_5035593_C_T 175 V>I No 1000Genomes
ENSVATH11218253 182 G>S No 1000Genomes
tmp_1_5035355_G_T 227 L>I No 1000Genomes
ENSVATH04577214 232 F>S No 1000Genomes
ENSVATH11218250 238 G>C No 1000Genomes
ENSVATH04577211 254 N>S No 1000Genomes
tmp_1_5035192_C_T 255 D>N No 1000Genomes
ENSVATH01051375 258 A>V No 1000Genomes
tmp_1_5035179_T_C 259 Q>R No 1000Genomes
tmp_1_5035165_G_C 264 L>V No 1000Genomes
tmp_1_5035137_G_C 273 T>S No 1000Genomes
ENSVATH13897173 288 I>V No 1000Genomes
ENSVATH00023540 292 F>V No 1000Genomes
ENSVATH01051359 299 T>A No 1000Genomes
ENSVATH01051357 303 G>E No 1000Genomes
tmp_1_5034759_T_C 314 E>G No 1000Genomes
ENSVATH00023537 316 A>V No 1000Genomes
tmp_1_5034751_C_A 317 A>S No 1000Genomes
ENSVATH00023536 326 M>I No 1000Genomes
tmp_1_5034577_T_C 331 I>V No 1000Genomes
ENSVATH00023534 335 S>G No 1000Genomes
ENSVATH01051334 350 S>G No 1000Genomes
ENSVATH04577193 354 L>H No 1000Genomes
ENSVATH04577194 354 L>I No 1000Genomes
tmp_1_5034290_A_G 359 V>A No 1000Genomes
ENSVATH11218135 362 S>P No 1000Genomes
tmp_1_5034266_A_C 367 V>G No 1000Genomes
tmp_1_5034267_C_T 367 V>I No 1000Genomes
tmp_1_5034261_C_A 369 V>F No 1000Genomes
ENSVATH11217924 376 R>H No 1000Genomes
ENSVATH01051330 377 S>F No 1000Genomes
tmp_1_5034209_G_A 386 S>F No 1000Genomes
ENSVATH00023530 390 T>A No 1000Genomes
ENSVATH11217923 397 A>D No 1000Genomes
ENSVATH04577192 422 R>K No 1000Genomes
ENSVATH04577189 427 T>A No 1000Genomes
ENSVATH04577189 427 T>S No 1000Genomes
tmp_1_5033837_C_A 435 L>F No 1000Genomes
ENSVATH13897171 449 L>F No 1000Genomes
ENSVATH00023526 452 D>E No 1000Genomes
ENSVATH01051313 461 I>L No 1000Genomes
tmp_1_5033442_C_T 463 E>K No 1000Genomes
tmp_1_5033439_A_T 464 Y>N No 1000Genomes
ENSVATH13897170 485 E>K No 1000Genomes
ENSVATH00023520 492 P>H No 1000Genomes
ENSVATH00023519 509 V>L No 1000Genomes
ENSVATH00023518 513 D>N No 1000Genomes
tmp_1_5033281_T_G 516 E>D No 1000Genomes
ENSVATH00023517 525 I>M No 1000Genomes
ENSVATH01051310 528 I>M No 1000Genomes
ENSVATH00023516 534 N>K No 1000Genomes
ENSVATH04577183 550 T>A No 1000Genomes
ENSVATH04577182 570 T>S No 1000Genomes
ENSVATH11217801 575 D>E No 1000Genomes
ENSVATH13897169 579 L>F No 1000Genomes
ENSVATH01051303 582 R>C No 1000Genomes
ENSVATH04577181 582 R>H No 1000Genomes
ENSVATH04577180 587 N>T No 1000Genomes
ENSVATH01051301 595 K>Q No 1000Genomes
ENSVATH04577178 596 I>M No 1000Genomes
ENSVATH01051300 599 H>R No 1000Genomes
ENSVATH04577176 603 T>M No 1000Genomes
ENSVATH04577175 608 E>G No 1000Genomes
ENSVATH01051294 621 L>I No 1000Genomes
ENSVATH01051292 622 R>C No 1000Genomes
ENSVATH04577174 630 Q>E No 1000Genomes
ENSVATH01051290 633 I>N No 1000Genomes
ENSVATH01051290 633 I>S No 1000Genomes
ENSVATH01051291 633 I>V No 1000Genomes
ENSVATH01051279 654 E>K No 1000Genomes
tmp_1_5032631_T_A 656 K>N No 1000Genomes
tmp_1_5032632_T_G 656 K>T No 1000Genomes
ENSVATH00023512 664 D>A No 1000Genomes
ENSVATH04577168 669 V>G No 1000Genomes
ENSVATH01051272 673 L>F No 1000Genomes
ENSVATH01051271 680 H>Y No 1000Genomes
ENSVATH01051270 688 G>S No 1000Genomes
ENSVATH04577165 699 L>I No 1000Genomes
ENSVATH04577164 708 H>L No 1000Genomes
ENSVATH01051268 711 V>G No 1000Genomes
ENSVATH00023509 721 H>N No 1000Genomes
tmp_1_5032217_T_G 739 L>F No 1000Genomes
tmp_1_5032195_T_C 747 R>G No 1000Genomes
tmp_1_5032186_C_T 750 A>T No 1000Genomes
tmp_1_5032180_C_T 752 G>S No 1000Genomes

No associated diseases with Q3YL57

1 regional properties for Q3YL57

Type Name Position InterPro Accession
domain Cation/H+ exchanger 36 - 446 IPR006153

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
potassium:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in).
sodium:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).

4 GO annotations of biological process

Name Definition
lithium ion export across the plasma membrane The directed movement of lithium ion out of a cell or organelle.
potassium ion transmembrane transport A process in which a potassium ion is transported from one side of a membrane to the other.
regulation of intracellular pH Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion.
sodium ion import across plasma membrane The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q4G0N8 SLC9C1 Sodium/hydrogen exchanger 10 Homo sapiens (Human) PR
Q84WG1 NHX3 Sodium/hydrogen exchanger 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q8S397 NHX4 Sodium/hydrogen exchanger 4 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MTSIIGAALP YKSPEKAIAS SSYSAENDSS PVDAVIFAGT SLVLGTACRY LFNGTRVPYT
70 80 90 100 110 120
VVLLVIGIFL GSLEYGTKHN LGKLGHGIRI WNGINPDLLL AVFLPVLLFE SSFSMDVHQI
130 140 150 160 170 180
KRCMGQMVLL AGPGVLISTF CLGALIKLTF PYNWDWKTSL LLGGLLGATD PVAVVALLKE
190 200 210 220 230 240
LGASKKMTTL IDGESLMNDG VSVVVFQLFF KMVMGHNSDW GSIIKFLVQN SFGAVGIGLA
250 260 270 280 290 300
FGIASVFWLK FIFNDTVAQI TVTLSASYFA YYTAQEWAGV SGILTVMILG MFFAAFARTA
310 320 330 340 350 360
FKGDSHQSLH HFWEMAAYIA NTLVFMLSGV IIAESVLSGQ TISYKGNSWS FLFLLYLYVQ
370 380 390 400 410 420
LSRCVVVGVL YPLLCRSGYG LDWKESIILT WSGLRGAVSL SLALSVKQSS GNSYLSSDTG
430 440 450 460 470 480
TRFLFLTGGI VFLTLVVNGS TTQLLLHLLR MDTLTATKKR ILEYTKFEMM KTALKAFENL
490 500 510 520 530 540
GDDEELGSAD WPTVIRHISS LKDLEGRQVN PHDGYEAGSL DPTNIMDIRI RFLNGVQAAY
550 560 570 580 590 600
WEMLDDGRIT QCTANVLMQS VDEALDLVST SSLSDWRGLE PRVHFPNYYK FLQSKIIPHK
610 620 630 640 650 660
LVTHLIVERL ESACYISSAF LRAHRIARQQ LHIFLGNSNI ASTVINESEV EGEEAKQFLE
670 680 690 700 710 720
DVRDSFPQVL SVLKTRQVTH YVLNHLNGYI KNLEKVGLLE GKEVSHLHDV VQSDLKKLLR
730 740 750
HPPSLKLPNV DDLITSNPLL KDRSSFRSLA IGETDA