Q8BGS1
PR
Gene name |
Epb41l5 (Epb4.1l5, Kiaa1548) |
Protein name |
Band 4.1-like protein 5 |
Names |
Erythrocyte membrane protein band 4.1-like 5 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:226352 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BGS1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BGS1-F1 | Predicted | AlphaFoldDB |
37 variants for Q8BGS1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388495807 | 90 | D>E | No | EVA | |
| rs3388493873 | 90 | D>N | No | EVA | |
| rs3390505316 | 186 | E>G | No | EVA | |
| rs3390547045 | 249 | L>M | No | EVA | |
| rs3390542189 | 249 | L>R | No | EVA | |
| rs3388493215 | 261 | T>I | No | EVA | |
| rs3388495771 | 270 | K>R | No | EVA | |
| rs3388490881 | 285 | V>I | No | EVA | |
| rs3388494796 | 382 | M>K | No | EVA | |
| rs583528544 | 386 | T>P | No | EVA | |
| rs220856411 | 412 | S>P | No | EVA | |
| rs3388492142 | 417 | T>S | No | EVA | |
| rs231592710 | 422 | C>S | No | EVA | |
| rs253189208 | 424 | A>P | No | EVA | |
| rs240660645 | 426 | Q>L | No | EVA | |
| rs218564339 | 428 | E>D | No | EVA | |
| rs584230249 | 433 | P>L | No | EVA | |
| rs1135034364 | 441 | H>N | No | EVA | |
| rs30686548 | 456 | P>L | No | EVA | |
| rs30686549 | 466 | V>E | No | EVA | |
| rs242251453 | 481 | T>N | No | EVA | |
| rs3388493187 | 490 | E>* | No | EVA | |
| rs3388493894 | 512 | E>G | No | EVA | |
| rs3388492175 | 512 | E>K | No | EVA | |
| rs3388494628 | 513 | T>A | No | EVA | |
| rs3388492128 | 550 | P>L | No | EVA | |
| rs3388492128 | 550 | P>Q | No | EVA | |
| rs3388495723 | 555 | V>A | No | EVA | |
| rs3388493167 | 559 | P>H | No | EVA | |
| rs3388493767 | 574 | H>Q | No | EVA | |
| rs260782731 | 587 | N>S | No | EVA | |
| rs248242620 | 595 | T>P | No | EVA | |
| rs30686484 | 604 | D>G | No | EVA | |
| rs246697150 | 623 | A>D | No | EVA | |
| rs3388490849 | 641 | T>I | No | EVA | |
| rs255959750 | 678 | Y>F | No | EVA | |
| rs3388494874 | 694 | F>I | No | EVA |
No associated diseases with Q8BGS1
7 regional properties for Q8BGS1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GAF domain | 158 - 317 | IPR003018 |
| domain | Histidine kinase/HSP90-like ATPase | 455 - 587 | IPR003594 |
| domain | Signal transduction histidine kinase, dimerisation/phosphoacceptor domain | 341 - 408 | IPR003661 |
| domain | Signal transduction histidine kinase-related protein, C-terminal | 511 - 525 | IPR004358-1 |
| domain | Signal transduction histidine kinase-related protein, C-terminal | 529 - 539 | IPR004358-2 |
| domain | Signal transduction histidine kinase-related protein, C-terminal | 546 - 564 | IPR004358-3 |
| domain | Histidine kinase domain | 350 - 587 | IPR005467 |
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| adherens junction | A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules. |
| cell leading edge | The area of a motile cell closest to the direction of movement. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| focal adhesion | A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| photoreceptor inner segment | The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| ruffle membrane | The portion of the plasma membrane surrounding a ruffle. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cytoskeletal protein binding | Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). |
| protein domain specific binding | Binding to a specific domain of a protein. |
30 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| actomyosin structure organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. |
| apical constriction | The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell. |
| axial mesoderm development | The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. |
| axial mesoderm morphogenesis | The process in which the anatomical structures of the axial mesoderm are generated and organized. |
| cell morphogenesis involved in differentiation | The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. |
| cellular response to transforming growth factor beta stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. |
| ectoderm development | The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. |
| embryonic foregut morphogenesis | The process in which the anatomical structures of the foregut are generated and organized, during the embryonic phase. |
| endoderm development | The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. |
| epithelial cell morphogenesis | The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state. |
| epithelial to mesenchymal transition | A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. |
| in utero embryonic development | The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. |
| left/right axis specification | The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes). |
| mesoderm development | The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. |
| mesoderm migration involved in gastrulation | The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism. |
| negative regulation of cell-cell adhesion | Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. |
| negative regulation of protein binding | Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding. |
| neural plate morphogenesis | The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue. |
| paraxial mesoderm development | The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube. |
| positive regulation of cell-matrix adhesion | Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix. |
| positive regulation of epithelial cell migration | Any process that activates or increases the frequency, rate or extent of epithelial cell migration. |
| positive regulation of focal adhesion assembly | Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions. |
| positive regulation of protein binding | Any process that activates or increases the frequency, rate or extent of protein binding. |
| post-transcriptional regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. |
| regulation of establishment of protein localization | Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location. |
| somite rostral/caudal axis specification | The establishment, maintenance and elaboration of the rostro-caudal axis of a somite, prior to the morphological formation of a somite boundary. |
| somitogenesis | The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. |
| substrate-dependent cell migration, cell attachment to substrate | The formation of adhesions that stabilize protrusions at the leading edge of a migrating cell; involves integrin activation, clustering, and the recruitment of structural and signaling components to nascent adhesions. |
| unidimensional cell growth | The process in which a cell irreversibly increases in size in one |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q58CU2 | EPB41L5 | Band 4.1-like protein 5 | Bos taurus (Bovine) | PR |
| Q9MYU8 | EPB41L5 | Band 4.1-like protein 5 | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| A2A2Y4 | FRMD3 | FERM domain-containing protein 3 | Homo sapiens (Human) | PR |
| Q7Z6J6 | FRMD5 | FERM domain-containing protein 5 | Homo sapiens (Human) | PR |
| Q9HCS5 | EPB41L4A | Band 4.1-like protein 4A | Homo sapiens (Human) | PR |
| Q9HCM4 | EPB41L5 | Band 4.1-like protein 5 | Homo sapiens (Human) | PR |
| P52963 | Epb41l4a | Band 4.1-like protein 4A | Mus musculus (Mouse) | PR |
| Q6P5H6 | Frmd5 | FERM domain-containing protein 5 | Mus musculus (Mouse) | PR |
| Q8BHD4 | Frmd3 | FERM domain-containing protein 3 | Mus musculus (Mouse) | PR |
| O70318 | Epb41l2 | Band 4.1-like protein 2 | Mus musculus (Mouse) | PR |
| Q9Z2H5 | Epb41l1 | Band 4.1-like protein 1 | Mus musculus (Mouse) | PR |
| P48193 | Epb41 | Protein 4.1 | Mus musculus (Mouse) | PR |
| Q9WV92 | Epb41l3 | Band 4.1-like protein 3 | Mus musculus (Mouse) | PR |
| Q0P4Q4 | frmd3 | FERM domain-containing protein 3 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| O57457 | epb41l4a | Band 4.1-like protein 4 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLSFLRRTLG | RRSMRKHAEK | ERLREAQRAA | THIPAAGDAK | SIITCRVSLL | DGTDVSVDLP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KKAKGQELFD | QIMYHLDLIE | SDYFGLRFMD | SAQVAHWLDG | TKSIKKQVKI | GSPYCLHLRV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KFYSSEPNNL | REELTRYLFV | LQLKQDILSG | KLECPFDTAV | QLAAYNLQAE | LGDYDLAEHS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PELVSEFRFV | PIQTEEMELA | IFEKWKEYRG | QTPAQAETNY | LNKAKWLEMY | GVDMHVVKAR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DGNDYSLGLT | PTGVLVFEGE | TKIGLFFWPK | ITRLDFKKNK | LTLVVVEDDD | QGKEQEHTFV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FRLDHPKACK | HLWKCAVEHH | AFFRLRGPVQ | KSSHRSGFIR | LGSRFRYSGK | TEYQTTKTNK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ARRSTSFERR | PSKRYSRRTL | QMKASTTQPE | DLGVLNASAQ | KSDSQQAWGV | MSPVPVTSSS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SCGAVQVEIE | NLPQTSATEQ | HDRKCLPLSV | DLLNSPDLLE | TTIGDVTRTS | ETSAPFPAPD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TINVATRSNE | LEEFKAECET | LKDDTEKLKQ | LETEQTILPS | LRPTIDINVN | SQEEVVKLTE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KCLNNAIENP | ALNAVKVPPD | FKSNILKAQV | EAVHKVTRED | SLLTHKNASV | QDAATNSTAF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NENDVPVCKD | SLTPVHGTAA | DSASVLKDAT | DELDALLLSL | TENLMDHTVT | PQVSSPSMIT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| PRWIIPQSAT | ISNGLAGYGA | SLAGTDECSQ | KDGFSLISPP | APFLVDAVTS | SAPPLPEDST |
| 730 | |||||
| LKQKCLLTTE | L |