O57457

PR
Gene name
epb41l4a
Protein name
Band 4.1-like protein 4
Names
Erythrocyte membrane protein band 4.1-like 4A, Protein Nbl4
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

272-619 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O57457

Entry ID Method Resolution Chain Position Source
AF-O57457-F1 Predicted AlphaFoldDB

No variants for O57457

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O57457

No associated diseases with O57457

9 regional properties for O57457

Type Name Position InterPro Accession
domain FERM domain 11 - 299 IPR000299
domain FERM adjacent 310 - 357 IPR014847
domain FERM, N-terminal 15 - 82 IPR018979
domain FERM, C-terminal PH-like domain 215 - 303 IPR018980
conserved_site FERM conserved site 70 - 102 IPR019747-1
conserved_site FERM conserved site 181 - 210 IPR019747-2
domain FERM central domain 103 - 211 IPR019748
domain Band 4.1 domain 7 - 211 IPR019749
domain Band 4.1-like protein 4A, FERM domain, F1 sub-domain 9 - 102 IPR030696

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

1 GO annotations of molecular function

Name Definition
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.

1 GO annotations of biological process

Name Definition
actomyosin structure organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q58CU2 EPB41L5 Band 4.1-like protein 5 Bos taurus (Bovine) PR
Q9HCM4 EPB41L5 Band 4.1-like protein 5 Homo sapiens (Human) PR
A2A2Y4 FRMD3 FERM domain-containing protein 3 Homo sapiens (Human) PR
Q7Z6J6 FRMD5 FERM domain-containing protein 5 Homo sapiens (Human) PR
Q9HCS5 EPB41L4A Band 4.1-like protein 4A Homo sapiens (Human) PR
Q8BHD4 Frmd3 FERM domain-containing protein 3 Mus musculus (Mouse) PR
Q6P5H6 Frmd5 FERM domain-containing protein 5 Mus musculus (Mouse) PR
Q8BGS1 Epb41l5 Band 4.1-like protein 5 Mus musculus (Mouse) PR
P52963 Epb41l4a Band 4.1-like protein 4A Mus musculus (Mouse) PR
Q0P4Q4 frmd3 FERM domain-containing protein 3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MSCFCSVQEE FYCEVLLLDE SKLILTTQQQ GIKKSTRGSV VLDYVFSHVN LAETEYFGVR
70 80 90 100 110 120
YCDRSHQTFW LDPSKTLAEH KDLIATGPPY TLYFGVKFYA EDPGKLKEEI TRYQFFLQVK
130 140 150 160 170 180
QDVLQGRLPC AFNISAQLAA LAIQSELGDY DPYKHTAGYV SEYRFVPDQK EDLEDSIEQI
190 200 210 220 230 240
HKTLLGQVPA EAENNYLAIA KTLEMYGVDL HPVFGEKQAE YFLGLTPVGV VVYKNKTQVG
250 260 270 280 290 300
KYFWPRITKV YFKETQFELR VLGRDCNETS FFFDAASKTA CKNLWKCCVE HHTFFRMPEN
310 320 330 340 350 360
ESNSLTRKLS KFSSLGSKHR YSGKTAMQIG RESTETLPRA DLQVIRTRSK TYPKRSTQPA
370 380 390 400 410 420
GRNNGGQAVT KMENTSEGQP KTSALTPVKS PRVKAESASV QQEKPSAPWE EDAPQSGLYN
430 440 450 460 470 480
SASERNKSPK FPKAHRRSPS GGSENEPRHR RGQTADDAQA NKQHRRRSRS RGNTSSGSES
490 500 510 520 530 540
ENSNREHRKK RNRSRQSNEM VDSAPQWEVV LRRQKEKTPN DPNQRRSRHR SRSRSPDVQA
550 560 570 580 590 600
KEQLWKHIQK ELVDPSGLSE EQLKEIPYKK VETQGDPIKI RHSHSPRSFG STGAPTARTE
610
RGLCCPKSTL ALIWFLLWL