Q6P5H6

PR
Gene name
Frmd5
Protein name
FERM domain-containing protein 5
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:228564
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

300-506 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6P5H6

Entry ID Method Resolution Chain Position Source
AF-Q6P5H6-F1 Predicted AlphaFoldDB

24 variants for Q6P5H6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388584087 55 K>* No EVA
rs3388583735 69 R>L No EVA
rs3388587359 72 L>* No EVA
rs3388584695 119 R>S No EVA
rs3388581890 144 E>V No EVA
rs3388584151 145 I>S No EVA
rs3413117345 163 F>Y No EVA
rs3388580761 166 K>N No EVA
rs3388586117 184 S>I No EVA
rs3388586082 195 F>I No EVA
rs3388580783 207 V>M No EVA
rs3392076694 240 F>L No EVA
rs3392130330 241 I>M No EVA
rs3388584131 329 E>K No EVA
rs3388584741 332 A>G No EVA
rs3388580753 346 M>V No EVA
rs3388579264 377 M>V No EVA
rs27425158 417 A>T No EVA
rs3388579601 418 V>M No EVA
rs3388583769 457 E>Q No EVA
rs3412932138 469 A>V No EVA
rs3388581864 472 A>* No EVA
rs3388587318 472 A>V No EVA
rs3388584176 474 A>D No EVA

No associated diseases with Q6P5H6

7 regional properties for Q6P5H6

Type Name Position InterPro Accession
domain FERM domain 17 - 298 IPR000299
domain FERM adjacent 308 - 354 IPR014847
domain FERM, N-terminal 21 - 83 IPR018979
domain FERM, C-terminal PH-like domain 214 - 302 IPR018980
conserved_site FERM conserved site 71 - 100 IPR019747
domain FERM central domain 103 - 210 IPR019748
domain Band 4.1 domain 13 - 210 IPR019749

Functions

Description
EC Number
Subcellular Localization
  • Cell junction, adherens junction
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
adherens junction A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

3 GO annotations of molecular function

Name Definition
cytoskeletal protein binding Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
integrin binding Binding to an integrin.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

4 GO annotations of biological process

Name Definition
actomyosin structure organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.
negative regulation of cell motility Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility.
positive regulation of cell adhesion Any process that activates or increases the frequency, rate or extent of cell adhesion.
regulation of cell migration Any process that modulates the frequency, rate or extent of cell migration.

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q58CU2 EPB41L5 Band 4.1-like protein 5 Bos taurus (Bovine) PR
Q9HCS5 EPB41L4A Band 4.1-like protein 4A Homo sapiens (Human) PR
Q9HCM4 EPB41L5 Band 4.1-like protein 5 Homo sapiens (Human) PR
A2A2Y4 FRMD3 FERM domain-containing protein 3 Homo sapiens (Human) PR
Q7Z6J6 FRMD5 FERM domain-containing protein 5 Homo sapiens (Human) PR
Q8BGS1 Epb41l5 Band 4.1-like protein 5 Mus musculus (Mouse) PR
P52963 Epb41l4a Band 4.1-like protein 4A Mus musculus (Mouse) PR
Q8BHD4 Frmd3 FERM domain-containing protein 3 Mus musculus (Mouse) PR
O70318 Epb41l2 Band 4.1-like protein 2 Mus musculus (Mouse) PR
Q9Z2H5 Epb41l1 Band 4.1-like protein 1 Mus musculus (Mouse) PR
P48193 Epb41 Protein 4.1 Mus musculus (Mouse) PR
Q9WV92 Epb41l3 Band 4.1-like protein 3 Mus musculus (Mouse) PR
Q0P4Q4 frmd3 FERM domain-containing protein 3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
O57457 epb41l4a Band 4.1-like protein 4 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MLSRLMSGSS RSLEREYSCT VRLLDDSEYT CTIQRDAKGQ YLFDLLCHHL NLLEKDYFGI
70 80 90 100 110 120
RFVDPDKQRH WLEFTKSVVK QLRSQPPFTM CFRVKFYPAD PAALKEEITR YLVFLQIKRD
130 140 150 160 170 180
LYHGRLLCKT SDAALLAAYI LQAEIGDYDP GKHPEGYSSK FQFFPKHSEK LEKKIAEIHK
190 200 210 220 230 240
TELSGQTPAT SELNFLRKAQ TLETYGVDPH PCKDVSGNAA FLAFTPFGFV VLQGNKRVHF
250 260 270 280 290 300
IKWNEVTKLK FEGKTFYLYV SQKEEKKIIL TYFAPTPEAC KHLWKCGIEN QAFYKLEKSS
310 320 330 340 350 360
QVRTVSSSNL FFKGSRFRYS GRVAKEVMES SAKIKREPPE IHRAGMVPSR SCPSITHGPR
370 380 390 400 410 420
LSSVPRTRRR AVHISIMEGL ESLRDSAHST PVRSSSHGDT FLPHVRSSRA DSNERVAVIA
430 440 450 460 470 480
DEAYSPADSV LPTPVAEHSL ELMLLSRQIN GATCSIEEEK ESEASTPTAT EAEALGGELR
490 500 510
ALCQGHGGSE QEQRVHLKGP QLQQQQWKGW GKSVPLD