AiPD: Autoinhibited Protein Database

Gene name	Frmd3
Protein name	FERM domain-containing protein 3
Names
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:242506
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

336-525 (Predicted disordered autoinhibitory region) PR

336-525 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8BHD4-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388679104	24	S>N	No	EVA
rs3388692801	29	N>D	No	EVA
rs3388695826	52	T>K	No	EVA
rs3388692276	86	W>*	No	EVA
rs3388679158	97	M>L	No	EVA
rs3388692260	109	V>M	No	EVA
rs3388692293	111	F>L	No	EVA
rs3388686222	125	R>K	No	EVA
rs3388690504	214	A>V	No	EVA
rs3388687687	236	F>Y	No	EVA
rs212254513	253	I>T	No	EVA
rs3388679168	260	D>N	No	EVA
rs3388670152	270	T>S	No	EVA
rs28114427	273	V>M	No	EVA
rs248221321	407	V>A	No	EVA
rs3388678443	413	A>S	No	EVA
rs3388686580	414	S>N	No	EVA
rs3388683757	479	D>E	No	EVA
rs255215076	523	V>I	No	EVA
rs3388689920	543	L>Q	No	EVA

Type	Name	Position	InterPro Accession
domain	FERM domain	32 - 312	IPR000299
domain	FERM adjacent	322 - 368	IPR014847
domain	FERM, N-terminal	36 - 98	IPR018979
domain	FERM, C-terminal PH-like domain	229 - 316	IPR018980
conserved_site	FERM conserved site	86 - 115	IPR019747
domain	FERM central domain	116 - 225	IPR019748
domain	Band 4.1 domain	28 - 225	IPR019749

		Description
EC Number
Subcellular Localization	Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Name	Definition
cytoskeletal protein binding	Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).

Name	Definition
actomyosin structure organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q58CU2	EPB41L5	Band 4.1-like protein 5	Bos taurus (Bovine)	PR
Q9HCS5	EPB41L4A	Band 4.1-like protein 4A	Homo sapiens (Human)	PR
Q9HCM4	EPB41L5	Band 4.1-like protein 5	Homo sapiens (Human)	PR
Q7Z6J6	FRMD5	FERM domain-containing protein 5	Homo sapiens (Human)	PR
A2A2Y4	FRMD3	FERM domain-containing protein 3	Homo sapiens (Human)	PR
Q8BGS1	Epb41l5	Band 4.1-like protein 5	Mus musculus (Mouse)	PR
P52963	Epb41l4a	Band 4.1-like protein 4A	Mus musculus (Mouse)	PR
Q6P5H6	Frmd5	FERM domain-containing protein 5	Mus musculus (Mouse)	PR
O70318	Epb41l2	Band 4.1-like protein 2	Mus musculus (Mouse)	PR
Q9Z2H5	Epb41l1	Band 4.1-like protein 1	Mus musculus (Mouse)	PR
P48193	Epb41	Protein 4.1	Mus musculus (Mouse)	PR
Q9WV92	Epb41l3	Band 4.1-like protein 3	Mus musculus (Mouse)	PR
Q0P4Q4	frmd3	FERM domain-containing protein 3	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
O57457	epb41l4a	Band 4.1-like protein 4	Danio rerio (Zebrafish) (Brachydanio rerio)	PR