AiPD: Autoinhibited Protein Database

Gene name	EPB41L5
Protein name	Band 4.1-like protein 5
Names	Erythrocyte membrane protein band 4.1-like 5
Species	Bos taurus (Bovine)
KEGG Pathway	bta:530941
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-67 (Predicted disordered autoinhibitory region) PR

1-67 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q58CU2-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs526558474	6	R>C	No	EVA
rs526840790	14	M>I	No	EVA
rs437667333	16	K>*	No	EVA
rs452072639	18	A>D	No	EVA
rs454538749	20	K>N	No	EVA
rs474645355	26	A>G	No	EVA
rs439967422	27	Q>L	No	EVA
rs438972573	33	I>M	No	EVA
rs473718847	33	I>N	No	EVA
rs458936939	34	P>T	No	EVA
rs482147519	35	A>S	No	EVA
rs446821575	38	D>E	No	EVA
rs475419969	38	D>G	No	EVA
rs461428786	38	D>H	No	EVA
rs466835301	39	A>S	No	EVA
rs477293203	40	R>G	No	EVA
rs445886010	40	R>P	No	EVA
rs437779973	41	A>D	No	EVA
rs437779973	41	A>G	No	EVA
rs469134921	41	A>P	No	EVA
rs454653383	42	V>A	No	EVA
rs454653383	42	V>G	No	EVA
rs468294364	43	I>L	No	EVA
rs433611693	43	I>S	No	EVA
rs453647169	44	T>P	No	EVA
rs439037603	46	R>G	No	EVA
rs475848537	47	V>A	No	EVA
rs475848537	47	V>G	No	EVA
rs452607722	47	V>L	No	EVA
rs444594021	48	S>A	No	EVA
rs461445952	49	L>H	No	EVA
rs475088414	50	L>Q	No	EVA
rs440397085	51	D>E	No	EVA
rs460527192	55	V>A	No	EVA
rs477313734	57	V>A	No	EVA
rs477313734	57	V>G	No	EVA
rs462831978	58	D>A	No	EVA
rs462831978	58	D>V	No	EVA
rs448258763	60	P>A	No	EVA
rs468904752	171	L>I	No	EVA
rs472882551	184	V>M	No	EVA
rs437699337	206	K>I	No	EVA
rs442759270	218	T>A	No	EVA
rs459535149	228	E>D	No	EVA
rs479668672	229	M>I	No	EVA
rs435308658	293	K>E	No	EVA
rs455338481	296	E>A	No	EVA
rs440495416	306	P>T	No	EVA
rs43308103	316	A>D	No	EVA
rs434338961	332	N>K	No	EVA
rs454439023	338	F>L	No	EVA
rs471263726	343	S>A	No	EVA
rs438328889	350	K>R	No	EVA
rs451688723	357	K>Q	No	EVA
rs443563778	360	K>T	No	EVA
rs463690319	363	R>K	No	EVA
rs474137490	367	F>L	No	EVA
rs380543179	370	R>K	No	EVA
rs380543179	370	R>M	No	EVA
rs459522579	372	S>R	No	EVA
rs135485635	427	V>G	No	EVA
rs136178223	428	E>G	No	EVA
rs479075096	456	N>T	No	EVA
rs463004881	459	D>G	No	EVA
rs483042819	460	T>R	No	EVA
rs110344076	487	A>V	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q58CU2

		Description
EC Number
Subcellular Localization	Cytoplasm Cell junction, adherens junction Cell membrane ; Peripheral membrane protein Photoreceptor inner segment
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
adherens junction	A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
photoreceptor inner segment	The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
cytoskeletal protein binding	Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).

Name	Definition
actomyosin structure organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9N179	EPB41	Protein 4.1	Bos taurus (Bovine)	PR
Q9MYU8	EPB41L5	Band 4.1-like protein 5	Canis lupus familiaris (Dog) (Canis familiaris)	PR
Q9HCS5	EPB41L4A	Band 4.1-like protein 4A	Homo sapiens (Human)	PR
A2A2Y4	FRMD3	FERM domain-containing protein 3	Homo sapiens (Human)	PR
Q7Z6J6	FRMD5	FERM domain-containing protein 5	Homo sapiens (Human)	PR
Q9HCM4	EPB41L5	Band 4.1-like protein 5	Homo sapiens (Human)	PR
P52963	Epb41l4a	Band 4.1-like protein 4A	Mus musculus (Mouse)	PR
Q8BHD4	Frmd3	FERM domain-containing protein 3	Mus musculus (Mouse)	PR
Q6P5H6	Frmd5	FERM domain-containing protein 5	Mus musculus (Mouse)	PR
Q8BGS1	Epb41l5	Band 4.1-like protein 5	Mus musculus (Mouse)	PR
Q0P4Q4	frmd3	FERM domain-containing protein 3	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
O57457	epb41l4a	Band 4.1-like protein 4	Danio rerio (Zebrafish) (Brachydanio rerio)	PR