P52963

PR
Gene name
Epb41l4a
Protein name
Band 4.1-like protein 4A
Names
ADP-ribosyltransferase C2 and C3 toxin-like 1, ARTC1, Mono(ADP-ribosyl)transferase 1, Erythrocyte membrane protein band 4.1-like 4A, Protein NBL4
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:13824
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

145-218 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P52963

Entry ID Method Resolution Chain Position Source
AF-P52963-F1 Predicted AlphaFoldDB

42 variants for P52963

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389501033 7 V>G No EVA
rs3411306023 29 Q>P No EVA
rs3389501036 98 F>I No EVA
rs3411763522 118 Q>R No EVA
rs3389471891 135 A>T No EVA
rs3389492628 170 K>E No EVA
rs3389484520 182 K>* No EVA
rs3389492631 196 Y>C No EVA
rs3389402614 215 G>* No EVA
rs3413042341 247 I>V No EVA
rs3389501059 253 K>R No EVA
rs3389505079 255 T>I No EVA
rs3389484485 308 K>* No EVA
rs3389484485 308 K>Q No EVA
rs3389501006 312 F>L No EVA
rs3389484537 338 P>L No EVA
rs3389501008 349 S>C No EVA
rs3389471868 360 Q>H No EVA
rs3389493967 361 P>S No EVA
rs31630463 367 I>V No EVA
rs3407749954 376 N>D No EVA
rs31631354 376 N>K No EVA
rs3389494020 419 P>S No EVA
rs3389493023 428 S>R No EVA
rs230173784 429 D>E No EVA
rs3389501084 434 P>S No EVA
rs3389497224 454 Q>K No EVA
rs3389440920 464 S>C No EVA
rs3389452081 472 Q>H No EVA
rs237161094 509 V>I No EVA
rs214443077 512 G>A No EVA
rs3389440893 517 A>T No EVA
rs3389402569 529 D>N No EVA
rs3389484535 544 P>S No EVA
rs3389402612 550 E>K No EVA
rs3389486210 566 L>M No EVA
rs3389486243 576 Y>F No EVA
rs3389507915 591 S>Y No EVA
rs3389493977 652 S>I No EVA
rs3389488839 666 A>D No EVA
rs3389497199 670 T>R No EVA
rs3389458844 679 A>S No EVA

No associated diseases with P52963

1 regional properties for P52963

Type Name Position InterPro Accession
domain Extracellular Endonuclease, subunit A 62 - 264 IPR020821

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

1 GO annotations of molecular function

Name Definition
cytoskeletal protein binding Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).

1 GO annotations of biological process

Name Definition
actomyosin structure organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q58CU2 EPB41L5 Band 4.1-like protein 5 Bos taurus (Bovine) PR
A2A2Y4 FRMD3 FERM domain-containing protein 3 Homo sapiens (Human) PR
Q7Z6J6 FRMD5 FERM domain-containing protein 5 Homo sapiens (Human) PR
Q9HCM4 EPB41L5 Band 4.1-like protein 5 Homo sapiens (Human) PR
Q9HCS5 EPB41L4A Band 4.1-like protein 4A Homo sapiens (Human) PR
O70318 Epb41l2 Band 4.1-like protein 2 Mus musculus (Mouse) PR
Q8BGS1 Epb41l5 Band 4.1-like protein 5 Mus musculus (Mouse) PR
Q6P5H6 Frmd5 FERM domain-containing protein 5 Mus musculus (Mouse) PR
Q8BHD4 Frmd3 FERM domain-containing protein 3 Mus musculus (Mouse) PR
Q9Z2H5 Epb41l1 Band 4.1-like protein 1 Mus musculus (Mouse) PR
P48193 Epb41 Protein 4.1 Mus musculus (Mouse) PR
Q9WV92 Epb41l3 Band 4.1-like protein 3 Mus musculus (Mouse) PR
Q0P4Q4 frmd3 FERM domain-containing protein 3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
O57457 epb41l4a Band 4.1-like protein 4 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MGCFCAVPEE FYCEVLLLDE SKLTLTTQQQ GIKKSTKGSV VLDHVFRHIN LVEIDYFGLR
70 80 90 100 110 120
YCDRSHQTYW LDPAKTLAEH KELINTGPPY TLYFGIKFYA EDPCKLKEEI TRYQFFLQVK
130 140 150 160 170 180
QDALQGRLPC PVNIAAQMGA YAIQAELGDH DPYKHTAGYV SEYRFVPDQK EELEEAIERI
190 200 210 220 230 240
HKTLMGQAPS EAELNYLRTA KSLEMYGVDL HPVYGENKSE YFLGLTPSGV VVYKNKKQVG
250 260 270 280 290 300
KYFWPRITKV HFKETQFELR VLGKDCNETS FFFEARSKTA CKHLWKCSVE HHTFFRMPDT
310 320 330 340 350 360
ESNSLSRKLS KFGSISYKHR YSGRTALQMS RDLSIQLPRP NQNVVRSRSK TYPKRVAQTQ
370 380 390 400 410 420
PTGSNNINRI TANTENGENE GTTKIIAPSP VKSFKKAKNE NSPDPQRSKS HAPWEENGPQ
430 440 450 460 470 480
SGLYNSSSDR TKSPKFPCAR QRNLSCGSDN DSSQLMRRRK AHNSGEDSDL KQRRRSRSRC
490 500 510 520 530 540
NTSSGSESEN SNREHRKKRN RTRQENDMVD SGPQWEAVLR RQKEKNQADP NNRRSRHRSR
550 560 570 580 590 600
SRSPDIQAKE ELWKHIQKEL VDPSGLSEEQ LKEIPYTKVE TQGDPVRIRH SHSPRSYRQY
610 620 630 640 650 660
RRSQCSDGER SVLSEVNSKT DLVPPLPVTR SSDAQGSGGS TVHQRRNGSK DSLIEEKSQL
670 680
STINPAGKPT AKTIKTIQAA RLKAET