Q6PHG2
Gene name |
hpx |
Protein name |
Hemopexin |
Names |
|
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:327588 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6PHG2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6PHG2-F1 | Predicted | AlphaFoldDB |
No variants for Q6PHG2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6PHG2 | |||||
No associated diseases with Q6PHG2
8 regional properties for Q6PHG2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Hemopexin-like domain | 49 - 243 | IPR000585 |
| repeat | Hemopexin-like repeats | 53 - 93 | IPR018487-1 |
| repeat | Hemopexin-like repeats | 99 - 153 | IPR018487-2 |
| repeat | Hemopexin-like repeats | 152 - 199 | IPR018487-3 |
| repeat | Hemopexin-like repeats | 198 - 243 | IPR018487-4 |
| repeat | Hemopexin-like repeats | 262 - 306 | IPR018487-5 |
| repeat | Hemopexin-like repeats | 305 - 353 | IPR018487-6 |
| repeat | Hemopexin-like repeats | 352 - 395 | IPR018487-7 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| heme transmembrane transporter activity | Enables the transfer of heme from one side of a membrane to the other. |
| metal ion binding | Binding to a metal ion. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular iron ion homeostasis | Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell. |
| cellular response to estrogen stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. |
| heme metabolic process | The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. |
17 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O77656 | MMP13 | Collagenase 3 | Bos taurus (Bovine) | PR |
| Q9GLE5 | MMP2 | 72 kDa type IV collagenase | Bos taurus (Bovine) | PR |
| Q3SZV7 | HPX | Hemopexin | Bos taurus (Bovine) | PR |
| Q90611 | MMP2 | 72 kDa type IV collagenase | Gallus gallus (Chicken) | PR |
| Q8MPP3 | Mmp2 | Matrix metalloproteinase-2 | Drosophila melanogaster (Fruit fly) | PR |
| P04004 | VTN | Vitronectin | Homo sapiens (Human) | PR |
| P45452 | MMP13 | Collagenase 3 | Homo sapiens (Human) | PR |
| Q99542 | MMP19 | Matrix metalloproteinase-19 | Homo sapiens (Human) | PR |
| Q9NPA2 | MMP25 | Matrix metalloproteinase-25 | Homo sapiens (Human) | PR |
| Q9H239 | MMP28 | Matrix metalloproteinase-28 | Homo sapiens (Human) | PR |
| P34960 | Mmp12 | Macrophage metalloelastase | Mus musculus (Mouse) | PR |
| P33435 | Mmp13 | Collagenase 3 | Mus musculus (Mouse) | PR |
| P33434 | Mmp2 | 72 kDa type IV collagenase | Mus musculus (Mouse) | PR |
| P28862 | Mmp3 | Stromelysin-1 | Mus musculus (Mouse) | PR |
| P23097 | Mmp13 | Collagenase 3 | Rattus norvegicus (Rat) | PR |
| Q63341 | Mmp12 | Macrophage metalloelastase | Rattus norvegicus (Rat) | PR |
| P33436 | Mmp2 | 72 kDa type IV collagenase | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRLIQALSLC | LALSLSLAAP | PQHKEDHSHK | GKPGGEGHKH | ELHHGAQLDR | CKGIEFDAVA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VNEEGVPYFF | KGDHLFKGFH | GKAELSNKTF | PELDDHHHLG | HVDAAFRMHS | EDSPDHHDHQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FFFLDNMVFS | YFKHKLEKDY | PKLISAVFPG | IPDHLDAAVE | CPKPDCPNDT | VIFFKGDEIY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HFNMHTKKVD | EKEFKSMPNC | TGAFRYMGHY | YCFHGHQFSK | FDPMTGEVHG | KYPKEARDYF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MRCPHFGSKT | TDDHIEREQC | SRVHLDAITS | DDAGNIYAFR | GHHFLSITGD | KFHSDTIESE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FKELHSEVDS | VFSYDGHFYM | IKDNDVFVYK | VGKPHTHLEG | YPKPLKDVLG | IEGPVDAAFV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| CEDHHVVHII | KGQSIYDVDL | KATPRKLVKE | GTITQFKRID | AAMCGPKGVT | VVIGNHFYNY |
| 430 | 440 | ||||
| DSVQVMLMAK | IMPEQQKVSQ | QLFGCDH |