O77656
Gene name |
MMP13 |
Protein name |
Collagenase 3 |
Names |
Matrix metalloproteinase-13, MMP-13 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:281914 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O77656
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O77656-F1 | Predicted | AlphaFoldDB |
No variants for O77656
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O77656 | |||||
No associated diseases with O77656
10 regional properties for O77656
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Hemopexin-like domain | 281 - 471 | IPR000585 |
| domain | Peptidase M10, metallopeptidase | 112 - 267 | IPR001818 |
| domain | Peptidoglycan binding-like | 33 - 91 | IPR002477 |
| domain | Peptidase, metallopeptidase | 109 - 268 | IPR006026 |
| repeat | Hemopexin-like repeats | 281 - 332 | IPR018487-1 |
| repeat | Hemopexin-like repeats | 331 - 377 | IPR018487-2 |
| repeat | Hemopexin-like repeats | 379 - 429 | IPR018487-3 |
| repeat | Hemopexin-like repeats | 428 - 471 | IPR018487-4 |
| binding_site | Peptidase M10A, cysteine switch, zinc binding site | 94 - 101 | IPR021158 |
| domain | Peptidase M10A, catalytic domain | 112 - 267 | IPR033739 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular matrix | A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| collagen binding | Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). |
| endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. |
| metalloendopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| zinc ion binding | Binding to a zinc ion (Zn). |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| bone morphogenesis | The process in which bones are generated and organized. |
| collagen catabolic process | The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells. |
| extracellular matrix disassembly | A process that results in the breakdown of the extracellular matrix. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
17 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9GLE5 | MMP2 | 72 kDa type IV collagenase | Bos taurus (Bovine) | PR |
| Q3SZV7 | HPX | Hemopexin | Bos taurus (Bovine) | PR |
| Q90611 | MMP2 | 72 kDa type IV collagenase | Gallus gallus (Chicken) | PR |
| Q8MPP3 | Mmp2 | Matrix metalloproteinase-2 | Drosophila melanogaster (Fruit fly) | PR |
| P04004 | VTN | Vitronectin | Homo sapiens (Human) | PR |
| Q99542 | MMP19 | Matrix metalloproteinase-19 | Homo sapiens (Human) | PR |
| Q9NPA2 | MMP25 | Matrix metalloproteinase-25 | Homo sapiens (Human) | PR |
| Q9H239 | MMP28 | Matrix metalloproteinase-28 | Homo sapiens (Human) | PR |
| P45452 | MMP13 | Collagenase 3 | Homo sapiens (Human) | PR |
| P34960 | Mmp12 | Macrophage metalloelastase | Mus musculus (Mouse) | PR |
| P33434 | Mmp2 | 72 kDa type IV collagenase | Mus musculus (Mouse) | PR |
| P28862 | Mmp3 | Stromelysin-1 | Mus musculus (Mouse) | PR |
| P33435 | Mmp13 | Collagenase 3 | Mus musculus (Mouse) | PR |
| Q63341 | Mmp12 | Macrophage metalloelastase | Rattus norvegicus (Rat) | PR |
| P33436 | Mmp2 | 72 kDa type IV collagenase | Rattus norvegicus (Rat) | PR |
| P23097 | Mmp13 | Collagenase 3 | Rattus norvegicus (Rat) | PR |
| Q6PHG2 | hpx | Hemopexin | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MHPRVLAGFL | FFSWTACWSL | PLPSDGDSED | LSEEDFQFAE | SYLKSYYYPQ | NPAGILKKTA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ASSVIDRLRE | MQSFFGLEVT | GRLDDNTLDI | MKKPRCGVPD | VGEYNVFPRT | LKWSKMNLTY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RIVNYTPDLT | HSEVEKAFRK | AFKVWSDVTP | LNFTRIHNGT | ADIMISFGTK | EHGDFYPFDG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PSGLLAHAFP | PGPNYGGDAH | FDDDETWTSS | SKGYNLFLVA | AHEFGHSLGL | DHSKDPGALM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FPIYTYTGKS | HFMLPDDDVQ | GIQSLYGPGD | EDPYSKHPKT | PDKCDPSLSL | DAITSLRGET |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LIFKDRFFWR | LHPQQVEAEL | FLTKSFGPEL | PNRIDAAYEH | PSHDLIFIFR | GRKFWALSGY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DILEDYPKKI | SELGFPKHVK | KISAALHFED | SGKTLFFSEN | QVWSYDDTNH | VMDKDYPRLI |
| 430 | 440 | 450 | 460 | 470 | |
| EEVFPGIGDK | VDAVYQKNGY | IYFFNGPIQF | EYSIWSNRIV | RVMTTNSLLW | C |