Q3SZV7

PR
Gene name
HPX
Protein name
Hemopexin
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:534509
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

6-77 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3SZV7

Entry ID Method Resolution Chain Position Source
AF-Q3SZV7-F1 Predicted AlphaFoldDB

No variants for Q3SZV7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3SZV7

No associated diseases with Q3SZV7

10 regional properties for Q3SZV7

Type Name Position InterPro Accession
domain Hemopexin-like domain 49 - 232 IPR000585-1
domain Hemopexin-like domain 248 - 453 IPR000585-2
conserved_site Hemopexin, conserved site 290 - 305 IPR018486
repeat Hemopexin-like repeats 58 - 97 IPR018487-1
repeat Hemopexin-like repeats 96 - 142 IPR018487-2
repeat Hemopexin-like repeats 141 - 185 IPR018487-3
repeat Hemopexin-like repeats 186 - 232 IPR018487-4
repeat Hemopexin-like repeats 252 - 299 IPR018487-5
repeat Hemopexin-like repeats 298 - 346 IPR018487-6
repeat Hemopexin-like repeats 350 - 394 IPR018487-7

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

2 GO annotations of molecular function

Name Definition
heme transmembrane transporter activity Enables the transfer of heme from one side of a membrane to the other.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
cellular iron ion homeostasis Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
heme metabolic process The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9GLE5 MMP2 72 kDa type IV collagenase Bos taurus (Bovine) PR
O77656 MMP13 Collagenase 3 Bos taurus (Bovine) PR
Q90611 MMP2 72 kDa type IV collagenase Gallus gallus (Chicken) PR
Q8MPP3 Mmp2 Matrix metalloproteinase-2 Drosophila melanogaster (Fruit fly) PR
P04004 VTN Vitronectin Homo sapiens (Human) PR
P45452 MMP13 Collagenase 3 Homo sapiens (Human) PR
Q99542 MMP19 Matrix metalloproteinase-19 Homo sapiens (Human) PR
Q9NPA2 MMP25 Matrix metalloproteinase-25 Homo sapiens (Human) PR
Q9H239 MMP28 Matrix metalloproteinase-28 Homo sapiens (Human) PR
P34960 Mmp12 Macrophage metalloelastase Mus musculus (Mouse) PR
P33435 Mmp13 Collagenase 3 Mus musculus (Mouse) PR
P33434 Mmp2 72 kDa type IV collagenase Mus musculus (Mouse) PR
P28862 Mmp3 Stromelysin-1 Mus musculus (Mouse) PR
P23097 Mmp13 Collagenase 3 Rattus norvegicus (Rat) PR
Q63341 Mmp12 Macrophage metalloelastase Rattus norvegicus (Rat) PR
P33436 Mmp2 72 kDa type IV collagenase Rattus norvegicus (Rat) PR
Q6PHG2 hpx Hemopexin Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MARALRVPVA LWLLGLCWSL AKAHPLARAP ELGHGVEGGN VAKPDPEVTE RCSDGWGFDA
70 80 90 100 110 120
TTLDEHGNML FLKGEFVWKG HAWARQLISE RWKDAPSPVD AAFRYDRNSV LLIKGDKFWV
130 140 150 160 170 180
YPPEKGEEYP KLLQEKFPGI PFPLDAAVEC HRGECSHEGV FFFQGNHTWF WDFSTKTIKK
190 200 210 220 230 240
RSWPAVGNCS SAIRWLNRYY CFRGNKFLRF DPVTGEVNST YPRDVRDYFM SCPNRGHAHR
250 260 270 280 290 300
NATQHMDKRC SPHLVLSALL SDNHSATYAF SENHYWRLDS SRDGWHSWRI EHLWPQGPST
310 320 330 340 350 360
VDAAFLWDKK LYLIQGTQVY IFLTRAGYTL VKDYPKQLEK EFGSPDGVCL HSVDAAFTCP
370 380 390 400 410 420
GSSQLYIMAG QKLWRLDLNL GAQATWTELP WLHTKVDGAL CTEKSLGPHS CSANGLGLYL
430 440 450
VQGPNLYCYK DVEELSKTKD LPQAQRMNSL LGCAPHQHS