Q6P3P5
Gene name |
b3gnt5 (TEgg092f15.1) |
Protein name |
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase |
Names |
Lactotriaosylceramide synthase, Lc(3)Cer synthase, Lc3 synthase, UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5, BGnT-5, Beta-1,3-Gn-T5, Beta-1,3-N-acetylglucosaminyltransferase 5, Beta3Gn-T5 |
Species |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
KEGG Pathway |
xtr:394849 |
EC number |
2.4.1.206: Hexosyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6P3P5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6P3P5-F1 | Predicted | AlphaFoldDB |
No variants for Q6P3P5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6P3P5 | |||||
No associated diseases with Q6P3P5
No regional properties for Q6P3P5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q6P3P5 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.1.206 | Hexosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide. |
| glycosyltransferase activity | Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). |
| lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity | Catalysis of the reaction: cytolipin-H + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| brain development | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| lipid metabolic process | The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. |
| protein glycosylation | A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8BG28 | B3galnt2 | UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 | Mus musculus (Mouse) | PR |
| Q864U6 | B3GALNT1 | UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 | Sus scrofa (Pig) | PR |
| Q8GXG6 | GALT4 | Hydroxyproline O-galactosyltransferase GALT4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8L7F9 | GALT1 | Beta-1,3-galactosyltransferase GALT1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RX55 | GALT5 | Hydroxyproline O-galactosyltransferase GALT5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q5XEZ1 | HPGT3 | Hydroxyproline O-galactosyltransferase HPGT3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A7XDQ9 | GALT2 | Hydroxyproline O-galactosyltransferase GALT2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ASW1 | GALT3 | Hydroxyproline O-galactosyltransferase GALT3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LV16 | GALT6 | Hydroxyproline O-galactosyltransferase GALT6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94F27 | HPTG1 | Hydroxyproline O-galactosyltransferase HPGT1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q5M900 | b3galnt2 | UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLISARRLRR | CQFFQLLTSC | FVLSLMALLV | QEDNSLINHV | KSYSYRYLIN | SYDFVNDSLS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VPRDRPDGAP | SYRYLINNRD | KCQNEDVLLL | LFVKTSPENR | RRRNAIRKTW | GNEDYIRSQY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AANIKVVFAL | GIEADPVKSH | QTQKDLVIEN | KRFNDLIQQD | FKDTFHNLTL | KLLLQFGWVN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SYCPSAKFIM | SADDDIFVHT | PNLVSYLKSL | PIETQDFWIG | RVHRGSPPIR | SKTSKYYVPY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EMYPWSSYPD | YTAGAAYVVS | KDVAAKVYEA | SQTLNTSLYI | DDVFMGICAN | KMGVVPQYHV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YFAGEGKAPY | HPCIYNKMIT | SHGHLDDLDY | LWRQATDPNV | KSLSAGVLGG | AYCKLVNIML |
| 370 | |||||
| LCKLSYVDTY | PCSAAWS |