Q5M900

PR
Gene name
b3galnt2
Protein name
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2
Names
Beta-1,3-GalNAc-T2, Beta-1,3-N-acetylgalactosaminyltransferase II
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:496641
EC number
2.4.1.313: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

253-325 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5M900

Entry ID Method Resolution Chain Position Source
AF-Q5M900-F1 Predicted AlphaFoldDB

No variants for Q5M900

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5M900

No associated diseases with Q5M900

3 regional properties for Q5M900

Type Name Position InterPro Accession
repeat Pentapeptide repeat 501 - 566 IPR001646
conserved_site Sugar transporter, conserved site 250 - 275 IPR005829
domain Major facilitator superfamily domain 154 - 722 IPR020846

Functions

Description
EC Number 2.4.1.313 Hexosyltransferases
Subcellular Localization
  • Golgi apparatus membrane ; Single-pass type II membrane protein
  • Endoplasmic reticulum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
acetylgalactosaminyltransferase activity Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide.
glycosyltransferase activity Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
UDP-glycosyltransferase activity Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule.

2 GO annotations of biological process

Name Definition
protein glycosylation A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
protein O-linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8BG28 B3galnt2 UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 Mus musculus (Mouse) PR
Q8L7F9 GALT1 Beta-1,3-galactosyltransferase GALT1 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RX55 GALT5 Hydroxyproline O-galactosyltransferase GALT5 Arabidopsis thaliana (Mouse-ear cress) PR
Q8GXG6 GALT4 Hydroxyproline O-galactosyltransferase GALT4 Arabidopsis thaliana (Mouse-ear cress) PR
A7XDQ9 GALT2 Hydroxyproline O-galactosyltransferase GALT2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ASW1 GALT3 Hydroxyproline O-galactosyltransferase GALT3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LV16 GALT6 Hydroxyproline O-galactosyltransferase GALT6 Arabidopsis thaliana (Mouse-ear cress) PR
Q6P3P5 b3gnt5 Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MRHLLLLFLC PCAIGVAFHL WLFNFSGLFT WFPVWSQRSY DIVVGVLSAR HNHELRNVIR
70 80 90 100 110 120
HTWLQHLKQH SSLSQRILVK FIIGSHGCDI PVEDREDPYS CKLLNITNPT FKQEIESFSI
130 140 150 160 170 180
PDIAALLTEH HVVNVNFRVL YPVVITRLGV FQHDSAAGFH RNITVKLFQT EHEEALFSAR
190 200 210 220 230 240
FSPASSGVQV NGIWYKPVEQ FILPEGFEGT VVWESHDPEG LLSGNVHRVI VNDGGGIFRI
250 260 270 280 290 300
TTVKEGLLPY EFTEGVEGIA GGFTYTIHEG EALLNTLETR PERIQIHLAA LEKEDALLQE
310 320 330 340 350 360
ESTTFQDIVF VHVVDTYRNV PSKLLNFYQW TAEFTSFEFL LKTDDDCFID IENVLEKIAH
370 380 390 400 410 420
KQLQKENTWW GNFRLNWAVD RTGKWQELEY LSPAYPAFAC GSGYVISQDI VQWLASNSQR
430 440 450 460 470 480
LKTYQGEDVS MGIWMSAIGP SRYQDSHWLC EKKCEAGMLS SPQYTPQELL ELWQQKERCG
NPCACEDR