Q864U6
Gene name |
B3GALNT1 (B3GALT3) |
Protein name |
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 |
Names |
Beta-1,3-GalNAc-T1, Beta-1,3-galactosyltransferase 3, Beta-1,3-GalTase 3, Beta3Gal-T3, Beta3GalT3, b3Gal-T3, Beta-3-Gx-T3, Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase, Globoside synthase, UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase |
Species |
Sus scrofa (Pig) |
KEGG Pathway |
ssc:397634 |
EC number |
2.4.1.79: Hexosyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q864U6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q864U6-F1 | Predicted | AlphaFoldDB |
4 variants for Q864U6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs697253654 | 174 | R>K | No | EVA | |
| rs712865627 | 176 | I>V | No | EVA | |
| rs708161542 | 258 | S>G | No | EVA | |
| rs710263749 | 280 | D>N | No | EVA |
No associated diseases with Q864U6
No regional properties for Q864U6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q864U6 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.1.79 | Hexosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide = UDP + beta-N-acetyl-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide. |
| glycosyltransferase activity | Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). |
| UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity | Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP. |
| UDP-glycosyltransferase activity | Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| lipid metabolic process | The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. |
| oligosaccharide biosynthetic process | The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. |
| protein glycosylation | A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8BG28 | B3galnt2 | UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 | Mus musculus (Mouse) | PR |
| Q8GXG6 | GALT4 | Hydroxyproline O-galactosyltransferase GALT4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8L7F9 | GALT1 | Beta-1,3-galactosyltransferase GALT1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RX55 | GALT5 | Hydroxyproline O-galactosyltransferase GALT5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A7XDQ9 | GALT2 | Hydroxyproline O-galactosyltransferase GALT2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ASW1 | GALT3 | Hydroxyproline O-galactosyltransferase GALT3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LV16 | GALT6 | Hydroxyproline O-galactosyltransferase GALT6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6P3P5 | b3gnt5 | Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAPALPITLP | SKMSLRSLKW | SLLLLSLLSF | LVMWYLSLPH | YNVIERVNWM | YFYEYEPIYR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QDFHFTLREH | SNCSHQNPFL | VILVTSHPAD | VKARQAIRVT | WGEKKSWWGY | EVLTFFLLGQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QAEREDKVLA | LSLEDEHLLY | GDIIRQDFLD | TYNNLTLKTI | MAFRWVTEFC | PNARYIMKTD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TDVFINTGNL | VKYLLNLNHS | EKFFTGYPLI | DNYSYRGFYQ | KTHISYQEYP | FKVFPPYCSG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LGYIMSRDLV | PRIYEMMSHV | KPIKFEDVYV | GICLNLLKVD | IHIPEDTNLF | FLYRIHLDVC |
| 310 | 320 | 330 | |||
| QLRRVIAAHG | FSSKEIITFW | QVMLRNTTCH | Y |