AiPD: Autoinhibited Protein Database

Gene name	HPTG1
Protein name	Hydroxyproline O-galactosyltransferase HPGT1
Names	Beta-1,3-galactosyltransferase 11
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT5G53340
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

51-211 (Predicted disordered autoinhibitory region) PR

51-211 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q94F27-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH07408584	4	K>R	No	1000Genomes
tmp_5_21643139_C_G	19	L>F	No	1000Genomes
tmp_5_21643140_A_C	19	L>W	No	1000Genomes
ENSVATH07408577	47	N>S	No	1000Genomes
tmp_5_21642961_T_C	48	E>G	No	1000Genomes
tmp_5_21642791_T_A	60	I>L	No	1000Genomes
tmp_5_21642607_C_A	92	G>V	No	1000Genomes
tmp_5_21642574_C_T	103	G>E	No	1000Genomes
tmp_5_21642555_T_A	109	R>S	No	1000Genomes
ENSVATH14629834	140	L>F	No	1000Genomes
ENSVATH14629833	164	S>R	No	1000Genomes
ENSVATH00731601	166	D>Y	No	1000Genomes
ENSVATH00731600	170	D>G	No	1000Genomes
ENSVATH07408566	174	S>N	No	1000Genomes
ENSVATH03420059	175	Q>E	No	1000Genomes
ENSVATH07408565	175	Q>R	No	1000Genomes
tmp_5_21642042_C_T	184	D>N	No	1000Genomes
tmp_5_21642039_C_T	185	V>I	No	1000Genomes
tmp_5_21641975_C_T	206	R>K	No	1000Genomes
ENSVATH00731598	210	Q>L	No	1000Genomes
tmp_5_21641948_G_A	215	A>V	No	1000Genomes
tmp_5_21641806_G_C	228	T>S	No	1000Genomes
tmp_5_21641786_C_T,G	235	E>K	No	1000Genomes
tmp_5_21641786_C_T,G	235	E>Q	No	1000Genomes
tmp_5_21641779_G_C	237	P>R	No	1000Genomes
ENSVATH07408560	254	N>D	No	1000Genomes
ENSVATH14629828	281	V>I	No	1000Genomes
tmp_5_21641440_C_G	285	A>P	No	1000Genomes
ENSVATH07408558	287	A>T	No	1000Genomes
ENSVATH07408557	293	N>S	No	1000Genomes
tmp_5_21641274_G_A	299	S>L	No	1000Genomes
tmp_5_21641197_A_T	325	C>S	No	1000Genomes
ENSVATH14629826	329	W>*	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Domain of unknown function DUF4094	13 - 90	IPR025298

		Description
EC Number
Subcellular Localization	Golgi apparatus membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endosome	A vacuole to which materials ingested by endocytosis are delivered.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi medial cisterna	The middle Golgi cisterna (or cisternae).
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
trans-Golgi network	The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.

Name	Definition
galactosyltransferase activity	Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid.
glycosyltransferase activity	Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
hydroxyproline O-galactosyltransferase activity	Catalysis of the transfer of galactose from UDP-galactose to hydroxyproline residues present in the peptide backbone.
UDP-glycosyltransferase activity	Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule.

Name	Definition
arabinogalactan protein metabolic process	The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein of highly varying length and domain complexity. These are O-glycosylated at one or more hydroxyproline residues by arabinogalactan (AG) type II groups, which consist of (1->3)-beta-galactan and (1->6)-beta-linked galactan chains connected to each other by (1->3,1->6)-linked branch points, O-3 and O-6 positions substituted with terminal arabinosyl residues. Also, rhamnose, fucose, glucuronic and galacturonic acid can be present in the glycan structures.
protein O-linked glycosylation via hydroxyproline	The glycosylation of proteins via 04 atom of hydroxyproline to form O4-glycosyl-L-hydroxyproline; the most common form is arabinofuranosyl-4-proline.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8BG28	B3galnt2	UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2	Mus musculus (Mouse)	PR
Q5XEZ1	HPGT3	Hydroxyproline O-galactosyltransferase HPGT3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8RX55	GALT5	Hydroxyproline O-galactosyltransferase GALT5	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LV16	GALT6	Hydroxyproline O-galactosyltransferase GALT6	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8GXG6	GALT4	Hydroxyproline O-galactosyltransferase GALT4	Arabidopsis thaliana (Mouse-ear cress)	PR
A7XDQ9	GALT2	Hydroxyproline O-galactosyltransferase GALT2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8L7F9	GALT1	Beta-1,3-galactosyltransferase GALT1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9ASW1	GALT3	Hydroxyproline O-galactosyltransferase GALT3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q6P3P5	b3gnt5	Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR