Q60899
Gene name |
Elavl2 (Hub) |
Protein name |
ELAV-like protein 2 |
Names |
ELAV-like neuronal protein 1, Hu-antigen B, HuB, Nervous system-specific RNA-binding protein Mel-N1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:15569 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q60899
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q60899-F1 | Predicted | AlphaFoldDB |
15 variants for Q60899
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388686142 | 86 | N>K | No | EVA | |
| rs3388681427 | 90 | P>L | No | EVA | |
| rs3388691209 | 92 | D>V | No | EVA | |
| rs3388695042 | 98 | N>S | No | EVA | |
| rs3394670332 | 112 | V>I | No | EVA | |
| rs3388698881 | 135 | T>S | No | EVA | |
| rs3394670345 | 161 | V>D | No | EVA | |
| rs3388673918 | 177 | I>N | No | EVA | |
| rs3388673918 | 177 | I>T | No | EVA | |
| rs3388682040 | 195 | T>I | No | EVA | |
| rs3410966510 | 198 | I>N | No | EVA | |
| rs3388689032 | 206 | P>L | No | EVA | |
| rs3388692659 | 208 | Q>P | No | EVA | |
| rs3388695075 | 215 | L>H | No | EVA | |
| rs3388693875 | 251 | S>C | No | EVA |
No associated diseases with Q60899
5 regional properties for Q60899
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | RNA recognition motif domain | 39 - 117 | IPR000504-1 |
| domain | RNA recognition motif domain | 125 - 205 | IPR000504-2 |
| domain | RNA recognition motif domain | 277 - 355 | IPR000504-3 |
| domain | HuB, RNA recognition motif 3 | 274 - 359 | IPR034914 |
| domain | HuB, RNA recognition motif 2 | 120 - 203 | IPR034999 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| ribonucleoprotein complex | A macromolecular complex that contains both RNA and protein molecules. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA binding | Binding to an RNA molecule or a portion thereof. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to leukemia inhibitory factor | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P26378 | ELAVL4 | ELAV-like protein 4 | Homo sapiens (Human) | PR |
| Q14576 | ELAVL3 | ELAV-like protein 3 | Homo sapiens (Human) | PR |
| Q12926 | ELAVL2 | ELAV-like protein 2 | Homo sapiens (Human) | PR |
| Q7TPD6 | Raver2 | Ribonucleoprotein PTB-binding 2 | Mus musculus (Mouse) | PR |
| Q60900 | Elavl3 | ELAV-like protein 3 | Mus musculus (Mouse) | PR |
| Q61701 | Elavl4 | ELAV-like protein 4 | Mus musculus (Mouse) | PR |
| Q9Z1D1 | Eif3g | Eukaryotic translation initiation factor 3 subunit G | Mus musculus (Mouse) | PR |
| O09032 | Elavl4 | ELAV-like protein 4 | Rattus norvegicus (Rat) | PR |
| Q8CH84 | Elavl2 | ELAV-like protein 2 | Rattus norvegicus (Rat) | PR |
| A4QNI8 | elavl4 | ELAV-like protein 4 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q28FX0 | elavl3 | ELAV-like protein 3 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q28GD4 | elavl2 | ELAV-like protein 2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| METQLSNGPT | CNNTANGPTT | VNNNCSSPVD | SGNTEDSKTN | LIVNYLPQNM | TQEELKSLFG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SIGEIESCKL | VRDKITGQSL | GYGFVNYIDP | KDAEKAINTL | NGLRLQTKTI | KVSYARPSSA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SIRDANLYVS | GLPKTMTQKE | LEQLFSQYGR | IITSRILVDQ | VTGISRGVGF | IRFDKRIEAE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EAIKGLNGQK | PPGATEPITV | KFANNPSQKT | NQAILSQLYQ | SPNRRYPGPL | AQQAQRFRLD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NLLNMAYGVK | SRFSPMTIDG | MTSLAGINIP | GHPGTGWCIF | VYNLAPDADE | SILWQMFGPF |
| 310 | 320 | 330 | 340 | 350 | |
| GAVTNVKVIR | DFNTNKCKGF | GFVTMTNYDE | AAMAIASLNG | YRLGDRVLQV | SFKTNKTHKA |