Q7TPD6
Gene name |
Raver2 (Kiaa1579) |
Protein name |
Ribonucleoprotein PTB-binding 2 |
Names |
Protein raver-2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:242570 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7TPD6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7TPD6-F1 | Predicted | AlphaFoldDB |
26 variants for Q7TPD6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs217848299 | 10 | G>A | No | EVA | |
| rs3388700358 | 135 | I>T | No | EVA | |
| rs217811761 | 153 | A>T | No | EVA | |
| rs3388701252 | 161 | F>L | No | EVA | |
| rs3388675306 | 180 | M>K | No | EVA | |
| rs3388697822 | 201 | A>T | No | EVA | |
| rs28202395 | 201 | A>V | No | EVA | |
| rs3388701215 | 238 | L>M | No | EVA | |
| rs3388697511 | 241 | F>C | No | EVA | |
| rs3388690607 | 248 | V>M | No | EVA | |
| rs28202374 | 255 | D>H | No | EVA | |
| rs3388697093 | 277 | V>I | No | EVA | |
| rs3388689010 | 295 | F>Y | No | EVA | |
| rs3388697558 | 319 | N>K | No | EVA | |
| rs3388697109 | 319 | N>T | No | EVA | |
| rs3388690647 | 333 | M>K | No | EVA | |
| rs3388694548 | 335 | S>I | No | EVA | |
| rs3388696723 | 337 | N>S | No | EVA | |
| rs3388701275 | 364 | S>R | No | EVA | |
| rs229584411 | 402 | P>S | No | EVA | |
| rs3388691670 | 413 | F>C | No | EVA | |
| rs3388701261 | 479 | S>P | No | EVA | |
| rs3388697509 | 503 | S>N | No | EVA | |
| rs3394607311 | 557 | P>Q | No | EVA | |
| rs28202271 | 620 | I>F | No | EVA | |
| rs3388696682 | 630 | R>S | No | EVA |
No associated diseases with Q7TPD6
1 regional properties for Q7TPD6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | SsrA-binding protein, conserved site | 23 - 35 | IPR020081 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of alternative mRNA splicing, via spliceosome | Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P26378 | ELAVL4 | ELAV-like protein 4 | Homo sapiens (Human) | PR |
| Q14576 | ELAVL3 | ELAV-like protein 3 | Homo sapiens (Human) | PR |
| Q12926 | ELAVL2 | ELAV-like protein 2 | Homo sapiens (Human) | PR |
| Q60900 | Elavl3 | ELAV-like protein 3 | Mus musculus (Mouse) | PR |
| Q60899 | Elavl2 | ELAV-like protein 2 | Mus musculus (Mouse) | PR |
| Q61701 | Elavl4 | ELAV-like protein 4 | Mus musculus (Mouse) | PR |
| Q8CH84 | Elavl2 | ELAV-like protein 2 | Rattus norvegicus (Rat) | PR |
| O09032 | Elavl4 | ELAV-like protein 4 | Rattus norvegicus (Rat) | PR |
| A4QNI8 | elavl4 | ELAV-like protein 4 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q28FX0 | elavl3 | ELAV-like protein 3 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q28GD4 | elavl2 | ELAV-like protein 2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAARGGGAGG | AGSGSGPSAG | TAGEAAEPAL | RPGEVAALHP | QEVAARLQRM | RRELSNRRKI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LVKNLPQDSS | SQEVHELLQD | YELKYCYVDR | NKRTAFVTLL | NGEQAQSAIQ | RFHQFSFRGR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ELTVQLQPTD | ALLCITNLPI | SFTLEEFEEL | VRAYGNIERC | FLVYSEVTGH | SKGYGFVEYM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KKDFAAKARL | ELLGRQMGAS | ALFAQWMDVN | LLASELIHSK | CLCIDKLPSD | YSDSEELLQL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FSGIHKPVFC | QLAQDEGSHG | GGFAVVEYST | AEHAEEVQQV | ADGITIKGSQ | VQLSFCAPGA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PGRSTLAVLI | AAQRAMHSNQ | KGLLPEPNPV | QIMKSLNNPA | MLQVLLQPQL | CGRAMKPVLG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VAPSLSHLLS | PSLPSAILHF | SKAQQSSAVG | NTSSLILQNL | SPLPLIQQQL | MKFDNAHTNN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KPGLLGEPPA | MVLQPALAIG | PPLPLKTDLG | HHGEAHKTSN | LIPPQTTLAA | GLGMLPFFSN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QLPAGQAGPG | RGTTQEKQSA | SVSISEASFS | GSQHYLQTFP | GLPAGGPLTG | NQKTPQSQPK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GTEVASKNQT | SLLGEPPKEI | RLSKNPYLNL | ASVLPSVCLS | TAGKGMPPKT | GIASNILDAI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SQGSESQHAL | EKCIAYSPSI | EDYAQASSLR | NEKRGSSYLI | SAPEGGPVEL | AGQHPQDTGV |
| 670 | |||||
| SYTETYLKKK | RVY |