AiPD: Autoinhibited Protein Database

P26378

Gene name	ELAVL4 (HUD, PNEM)
Protein name	ELAV-like protein 4
Names	Hu-antigen D, HuD, Paraneoplastic encephalomyelitis antigen HuD
Species	Homo sapiens (Human)
KEGG Pathway	hsa:1996
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-68 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-68 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for P26378

Entry ID	Method	Resolution	Chain	Position	Source
1FXL	X-ray	180 A	A	49-215	PDB
1G2E	X-ray	230 A	A	49-215	PDB
AF-P26378-F1	Predicted				AlphaFoldDB

174 variants for P26378

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs747098973 CA845313	2	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1400983164 CA340298966	4	N>S		No	ClinGen gnomAD
CA340298971 rs1160252807	5	G>S		No	ClinGen gnomAD
CA845315 rs781296512	8	M>T		No	ClinGen ExAC gnomAD
CA22467493 rs902567011	9	I>V		No	ClinGen gnomAD
CA340297704 rs1328238654	11	S>N		No	ClinGen TOPMed
rs761863819 CA845359	13	M>T		No	ClinGen ExAC gnomAD
CA340297729 rs750517639	14	E>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs555445078 CA845360	14	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs756230853 CA845362	15	P>S		No	ClinGen ExAC gnomAD
rs150277981 CA845366	21	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs755433268 CA845365	21	P>S		No	ClinGen ExAC gnomAD
rs1251084845 CA340297774	22	T>A		No	ClinGen gnomAD
rs1251084845 CA340297773	22	T>P		No	ClinGen gnomAD
rs770471086 CA845368	24	N>S		No	ClinGen ExAC TOPMed gnomAD
CA845369 rs780502540	26	S>N		No	ClinGen ExAC gnomAD
CA340297810 rs1356152656	27	N>K		No	ClinGen TOPMed
rs747257950 CA22467494	27	N>S		No	ClinGen gnomAD
CA22467495 rs1053672972	28	G>E		No	ClinGen gnomAD
rs1351649500 CA340297831	31	S>C		No	ClinGen gnomAD
rs1050931177 CA22467496	32	N>K		No	ClinGen TOPMed gnomAD
rs541366902 CA845370	32	N>S		No	ClinGen 1000Genomes ExAC gnomAD
CA340297853 rs1446048734	34	R>K		No	ClinGen TOPMed
CA340297858 rs1369439606	35	N>H		No	ClinGen gnomAD
CA845371 rs769284873	35	N>S		No	ClinGen ExAC TOPMed gnomAD
rs150394218 CA845373	37	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1012234646 CA22467498	39	P>H		No	ClinGen gnomAD
rs774263808 CA845375	40	M>T		No	ClinGen ExAC gnomAD
rs577777036 CA845376	42	T>I		No	ClinGen 1000Genomes ExAC gnomAD
rs752000055 CA22467499	44	A>T		No	ClinGen Ensembl
CA340297928 rs1321742053	46	T>A		No	ClinGen gnomAD
rs767501506 CA845377	47	D>G		No	ClinGen ExAC gnomAD
COSM3400862 CA845378 RCV000785703 rs116391279	55	V>I	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA340298025 rs1241348846	60	Q>K		No	ClinGen gnomAD
rs1474322779 CA340298029	60	Q>R		No	ClinGen gnomAD
CA22467500 rs971417184	61	N>S		No	ClinGen Ensembl
CA845380 rs766676470	62	M>I		No	ClinGen ExAC gnomAD
rs1459326800 COSM302125 CA340298115	72	G>R	central_nervous_system [Cosmic]	No	ClinGen cosmic curated gnomAD
rs765764372 CA845383	74	I>T		No	ClinGen ExAC TOPMed gnomAD
CA845382 rs755382094	74	I>V		No	ClinGen ExAC TOPMed
CA845384 rs753118324	76	E>G		No	ClinGen ExAC gnomAD
rs1232144655 CA340298223	87	I>T		No	ClinGen gnomAD
CA22467502 rs759928291	87	I>V		No	ClinGen Ensembl
CA845404 rs374811070	95	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA340299113 rs752957527	103	K>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1278816516 CA340299125	105	A>S		No	ClinGen gnomAD
CA340299149 rs1220729294	108	A>G		No	ClinGen gnomAD
rs1337978854 CA340299167	111	T>A		No	ClinGen TOPMed
CA845407 rs758825213 COSM3671790	111	T>I	Variant assessed as Somatic; 0.0 impact. prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs940845628 CA22471041	112	L>S		No	ClinGen TOPMed
CA845411 rs199634128	119	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1469105007 CA340299238	122	I>V		No	ClinGen TOPMed gnomAD
CA340299318 rs1572620166	124	V>I		No	ClinGen Ensembl
CA340299330 rs1370157409	126	Y>H		No	ClinGen gnomAD
rs868813722 CA22472845	129	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA22472846 rs989472197	130	S>R		No	ClinGen TOPMed
CA845436 rs758122922	133	S>L		No	ClinGen ExAC gnomAD
CA22472848 rs267598638	136	D>N		No	ClinGen Ensembl
CA340299401 rs1433948845	137	A>S		No	ClinGen TOPMed
rs374149997 CA845439	142	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA845440 rs199932597	143	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs775564920 CA845443	148	M>V		No	ClinGen ExAC gnomAD
rs763306293 CA845444	149	T>I		No	ClinGen ExAC gnomAD
rs1250338534 CA340299489	150	Q>L		No	ClinGen gnomAD
rs774725609 CA845446	156	L>F		No	ClinGen ExAC gnomAD
CA340299533 rs1368838245	156	L>R		No	ClinGen TOPMed
rs1175579240 CA340299547	158	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA340299552 rs1458930048	159	Q>R		No	ClinGen gnomAD
rs750975848 CA845449	161	G>S		No	ClinGen ExAC gnomAD
CA22472851 rs138779266	162	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
CA845450 rs200396874	162	R>H	Variant assessed as Somatic; 4.619e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs1572620923 CA340299587	165	T>A		No	ClinGen Ensembl
CA845451 rs369875371	166	S>L		No	ClinGen ESP ExAC gnomAD
CA845453 rs370062289	168	I>V		No	ClinGen ESP ExAC gnomAD
rs962063964 CA22472852	170	V>F		No	ClinGen gnomAD
CA22472853 rs17853533 VAR_058091	171	D>G		No	ClinGen UniProt Ensembl dbSNP
CA22472854 rs929829288	172	Q>P		No	ClinGen TOPMed
rs751438360 CA845455	173	V>D		No	ClinGen ExAC
rs1427053388 CA340299661	175	G>V		No	ClinGen TOPMed
CA340299681 rs1231539470	179	G>R		No	ClinGen gnomAD
rs1169691831 CA340299715	184	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA22473025 rs749270666	186	D>E		No	ClinGen Ensembl
rs751205371 CA845472	196	K>R		No	ClinGen ExAC TOPMed gnomAD
CA340299807 rs1259386502	197	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA22473026 rs267598639	200	G>D		No	ClinGen Ensembl
rs866002286 CA22473027	201	Q>*		No	ClinGen Ensembl
rs1211106652 CA340299856	204	S>T		No	ClinGen gnomAD
CA340299860 rs1484366574	205	G>S		No	ClinGen TOPMed gnomAD
CA340299870 rs1203348000	206	A>G		No	ClinGen TOPMed
rs767350030 CA340299876	207	T>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA845474 rs767350030	207	T>M		No	ClinGen ExAC gnomAD
rs756130254 CA845476	209	P>L		No	ClinGen ExAC TOPMed gnomAD
CA340299891 rs1379114396	210	I>V		No	ClinGen TOPMed gnomAD
rs1350636054 CA340299902	211	T>N		No	ClinGen TOPMed
CA340299930 rs1174438397	215	A>V		No	ClinGen gnomAD
CA340299945 rs370446022	217	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1572628359 CA340299942	217	N>T		No	ClinGen Ensembl
rs772277106 CA845482	218	P>S		No	ClinGen ExAC gnomAD
CA22473029 rs371102695	222	S>C		No	ClinGen ESP
rs773624398 CA845483	223	S>T		No	ClinGen ExAC gnomAD
CA340299996 rs1572628509	225	A>T		No	ClinGen Ensembl
rs144250728 CA845485	230	L>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA340300027 rs144250728	230	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA845487 COSM357151 rs762544492	235	N>D	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA22473030 rs1039135672	235	N>K		No	ClinGen Ensembl
CA340300068 rs1345370346	236	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs763451875 CA340300066	236	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs763739803 CA845489	237	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA845491 rs761620230	237	R>H		No	ClinGen ExAC TOPMed gnomAD
rs761620230 CA845490	237	R>L	Variant assessed as Somatic; 9.243e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs997892423 CA22473031	238	Y>H		No	ClinGen Ensembl
CA340300082 rs1460314684	239	P>A		No	ClinGen TOPMed
CA22473032 rs774540893	239	P>L		No	ClinGen Ensembl
rs969828287 CA22473033	241	P>S		No	ClinGen TOPMed gnomAD
rs1175366786 CA340300132	246	A>V		No	ClinGen gnomAD
CA845493 rs569206522	248	R>K		No	ClinGen 1000Genomes ExAC gnomAD
rs1188457168 CA340300219	257	M>L		No	ClinGen gnomAD
CA340300221 rs1420508897	257	M>T		No	ClinGen TOPMed gnomAD
CA340300246 rs1325738088	261	V>I		No	ClinGen TOPMed
rs781472470 CA845520	265	M>T		No	ClinGen ExAC gnomAD
CA340300314 rs1416346938	269	V>D		No	ClinGen gnomAD
CA845522 rs770467595	270	P>R		No	ClinGen ExAC gnomAD
CA845525 rs116030028	271	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA340300322 rs116030028	271	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA845524 rs116030028	271	P>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs772924325 CA845526	272	S>P		No	ClinGen ExAC gnomAD
rs760313718 CA845527	273	A>G		No	ClinGen ExAC gnomAD
rs1355484430 CA340300332	273	A>P		No	ClinGen TOPMed gnomAD
rs1355484430 CA340300333	273	A>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA340300341 rs1352823026	274	C>F		No	ClinGen gnomAD
CA340300347 rs1283346959	275	P>R		No	ClinGen TOPMed gnomAD
VAR_052204 CA845528 rs2494876	275	P>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA845529 rs776339902	276	P>L		No	ClinGen ExAC TOPMed gnomAD
CA845530 rs199787012	281	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA845531 rs765189019	283	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs763032801 COSM910495 CA845533	285	G>E	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
COSM3689751 rs1236212349 CA340300431	288	S>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs764091821 CA845534	289	L>F		No	ClinGen ExAC gnomAD
CA340300438 rs1159474949	289	L>H		No	ClinGen gnomAD
CA340300447 rs1407663589	291	G>R		No	ClinGen TOPMed gnomAD
CA340300461 rs1399342049	292	M>I		No	ClinGen gnomAD
CA845538 rs781450709	295	P>S		No	ClinGen ExAC gnomAD
rs1572647481 CA340300501	298	T>I		No	ClinGen Ensembl
rs750789231 CA845540	299	G>R		No	ClinGen ExAC gnomAD
rs368200868 CA340300511	300	T>I		No	ClinGen ESP TOPMed gnomAD
rs368200868 CA22473529	300	T>S		No	ClinGen ESP TOPMed gnomAD
rs756501874 CA845541	305	F>V		No	ClinGen ExAC gnomAD
rs1348209023 CA340300567	308	N>S		No	ClinGen gnomAD
CA340300580 rs1282739153	310	S>C		No	ClinGen TOPMed gnomAD
COSM1687655 rs755538583 CA845544	312	D>N	upper_aerodigestive_tract Variant assessed as Somatic; 0.0 impact. skin [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs746506386 CA845546 COSM3386225	314	D>N	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs776306356 CA845548	317	V>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs775408177 CA845551	334	I>T		No	ClinGen ExAC gnomAD
CA845553 rs762942843	342	C>W		No	ClinGen ExAC TOPMed gnomAD
CA340300828 rs1303937161	346	G>S		No	ClinGen gnomAD
CA22473531 rs868045736	349	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA340300847 rs1572648072	349	T>P		No	ClinGen Ensembl
rs1048552996 CA22473532	353	Y>C		No	ClinGen TOPMed
rs1572648137 CA340300889	354	D>E		No	ClinGen Ensembl
CA340300903 rs1341487754	356	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA340300911 rs1377921361	358	M>V		No	ClinGen TOPMed
rs17853531 VAR_058092 CA845559	361	A>T		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
CA22473534 rs941061407	365	G>E		No	ClinGen TOPMed
CA340300974 rs1437298847	367	R>C		No	ClinGen TOPMed
rs377132231 CA845561 COSM77643	367	R>H	ovary large_intestine Variant assessed as Somatic; 4.636e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed
CA340300978 rs1196239051	368	L>V		No	ClinGen gnomAD
CA845562 rs150762056	372	V>M		No	ClinGen ESP ExAC gnomAD
CA22473535 rs867053382	376	S>Y		No	ClinGen Ensembl
CA340301034 rs1271862494	377	F>L		No	ClinGen gnomAD
rs756742405 CA845565	380	N>S		No	ClinGen ExAC gnomAD
rs1279993985 CA340301069	381	K>N		No	ClinGen TOPMed
rs745455583 CA845567	383	H>P		No	ClinGen ExAC gnomAD
rs745455583 CA340301080	383	H>R		No	ClinGen ExAC gnomAD
CA845568 rs769429049	385	S>F		No	ClinGen ExAC gnomAD

No associated diseases with P26378

4 regional properties for P26378

Type	Name	Position	InterPro Accession
domain	RNA recognition motif domain	51 - 129	IPR000504-1
domain	RNA recognition motif domain	137 - 217	IPR000504-2
domain	RNA recognition motif domain	302 - 380	IPR000504-3
domain	HuD, RNA recognition motif 3	299 - 384	IPR034918

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Perikaryon Cell projection, dendrite Cell projection, axon Cell projection, growth cone	Co-localizes with ribosomal RNA in polysomes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

11 GO annotations of cellular component

Name	Definition
axon	The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
growth cone	The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nuclear envelope	The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
perikaryon	The portion of the cell soma (neuronal cell body) that excludes the nucleus.
polysomal ribosome	A ribosome bound to mRNA that forms part of a polysome.

5 GO annotations of molecular function

Name	Definition
mRNA 3'-UTR AU-rich region binding	Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs.
mRNA 3'-UTR binding	Binding to a 3' untranslated region of an mRNA molecule.
poly(A) binding	Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
pre-mRNA intronic pyrimidine-rich binding	Binding to a pyrimidine-rich (CU-rich) intronic sequence of a pre-messenger RNA (pre-mRNA).
translation regulator activity	Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.

16 GO annotations of biological process

Name	Definition
3'-UTR-mediated mRNA stabilization	An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.
aging	A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
associative learning	Learning by associating a stimulus (the cause) with a particular outcome (the effect).
cellular response to nerve growth factor stimulus	A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
cerebral cortex neuron differentiation	The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex.
dendrite morphogenesis	The process in which the anatomical structures of a dendrite are generated and organized.
locomotory behavior	The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
mRNA processing	Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
positive regulation of 3'-UTR-mediated mRNA stabilization	Any process that activates or increases the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization.
positive regulation of dendrite development	Any process that activates or increases the frequency, rate or extent of dendrite development.
regeneration	The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass).
regulation of translation at synapse, modulating synaptic transmission	Any process that modulates synaptic transmission by regulating translation occurring at the synapse.
response to cocaine	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.
response to endoplasmic reticulum stress	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
RNA processing	Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
RNA splicing	The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

12 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q14576	ELAVL3	ELAV-like protein 3	Homo sapiens (Human)	PR
Q12926	ELAVL2	ELAV-like protein 2	Homo sapiens (Human)	PR
O75821	EIF3G	Eukaryotic translation initiation factor 3 subunit G	Homo sapiens (Human)	PR
Q60900	Elavl3	ELAV-like protein 3	Mus musculus (Mouse)	PR
Q7TPD6	Raver2	Ribonucleoprotein PTB-binding 2	Mus musculus (Mouse)	PR
Q60899	Elavl2	ELAV-like protein 2	Mus musculus (Mouse)	PR
Q61701	Elavl4	ELAV-like protein 4	Mus musculus (Mouse)	PR
Q8CH84	Elavl2	ELAV-like protein 2	Rattus norvegicus (Rat)	PR
O09032	Elavl4	ELAV-like protein 4	Rattus norvegicus (Rat)	PR
Q28FX0	elavl3	ELAV-like protein 3	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q28GD4	elavl2	ELAV-like protein 2	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
A4QNI8	elavl4	ELAV-like protein 4	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MEWNGLKMII	STMEPQVSNG	PTSNTSNGPS	SNNRNCPSPM	QTGATTDDSK	TNLIVNYLPQ
70	80	90	100	110	120
NMTQEEFRSL	FGSIGEIESC	KLVRDKITGQ	SLGYGFVNYI	DPKDAEKAIN	TLNGLRLQTK
130	140	150	160	170	180
TIKVSYARPS	SASIRDANLY	VSGLPKTMTQ	KELEQLFSQY	GRIITSRILV	DQVTGVSRGV
190	200	210	220	230	240
GFIRFDKRIE	AEEAIKGLNG	QKPSGATEPI	TVKFANNPSQ	KSSQALLSQL	YQSPNRRYPG
250	260	270	280	290	300
PLHHQAQRFR	LDNLLNMAYG	VKRLMSGPVP	PSACPPRFSP	ITIDGMTSLV	GMNIPGHTGT
310	320	330	340	350	360
GWCIFVYNLS	PDSDESVLWQ	LFGPFGAVNN	VKVIRDFNTN	KCKGFGFVTM	TNYDEAAMAI
370	380
ASLNGYRLGD	RVLQVSFKTN	KAHKS