AiPD: Autoinhibited Protein Database

O75821

Gene name	EIF3G
Protein name	Eukaryotic translation initiation factor 3 subunit G
Names	eIF3g, Eukaryotic translation initiation factor 3 RNA-binding subunit, eIF-3 RNA-binding subunit, Eukaryotic translation initiation factor 3 subunit 4, eIF-3-delta, eIF3 p42, eIF3 p44
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8666
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-266 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-266 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

10 structures for O75821

Entry ID	Method	Resolution	Chain	Position	Source
2CQ0	NMR	-	A	231-320	PDB
2MJC	NMR	-	A	150-179	PDB
5K0Y	EM	580 A			PDB
6YBS	EM	310 A	o	1-320	PDB
6ZMW	EM	370 A	o	1-320	PDB
7QP6	EM	470 A	o	1-320	PDB
7QP7	EM	370 A	o	1-320	PDB
8OZ0	EM	350 A	7	1-320	PDB
8PPL	EM	265 A	Io	1-320	PDB
AF-O75821-F1	Predicted				AlphaFoldDB

218 variants for O75821

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA403964427 rs762560827	2	P>A		No	ClinGen ExAC gnomAD
CA9187309 rs200361874	2	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs762560827 CA9187310	2	P>T		No	ClinGen ExAC gnomAD
CA403964410 rs776642037 COSM3692293	3	T>I	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs776642037 CA403964412	3	T>N		No	ClinGen ExAC TOPMed gnomAD
CA9187308 rs748091858	3	T>P		No	ClinGen ExAC gnomAD
CA9187306 rs776642037	3	T>S		No	ClinGen ExAC TOPMed gnomAD
CA9187307 rs748091858	3	T>S		No	ClinGen ExAC gnomAD
CA9187305 rs746732180	4	G>A		No	ClinGen ExAC gnomAD
rs1453227727 CA403964408	4	G>R		No	ClinGen TOPMed
CA9187304 rs746732180	4	G>V		No	ClinGen ExAC gnomAD
CA9187303 rs758519529	5	D>E		No	ClinGen ExAC gnomAD
rs1205735317 CA403964369	6	F>L		No	ClinGen gnomAD
rs745999028 CA9187301	6	F>L		No	ClinGen ExAC TOPMed gnomAD
CA9187300 rs778953111	7	D>G		No	ClinGen ExAC gnomAD
rs771861822 CA9187267	8	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs759271944 CA403964286	9	K>N		No	ClinGen ExAC gnomAD
rs1224573301 CA403964290	9	K>R		No	ClinGen TOPMed
TCGA novel	12	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA403964235 rs1205961593	13	A>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA403964184 rs1475432088	16	V>M		No	ClinGen TOPMed
rs749415592 CA9187264	19	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1355651438 CA403964136	19	E>Q		No	ClinGen gnomAD
rs1392515005 CA403963936	24	K>E		No	ClinGen gnomAD
CA9187203 rs764693407	24	K>R		No	ClinGen ExAC gnomAD
TCGA novel	24	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1330184287 CA403963919	25	C>R		No	ClinGen gnomAD
CA403963900 rs1227623117	26	V>I		No	ClinGen TOPMed
CA403963889 rs1335207002	27	T>A		No	ClinGen gnomAD
rs1470736205 CA403963883	27	T>I		No	ClinGen gnomAD
CA305205338 rs867633866	29	E>*		No	ClinGen Ensembl
CA403963780 rs1361246257	35	P>L		No	ClinGen gnomAD
CA9187202 rs537407672	35	P>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1423195347 CA403963756	37	A>V		No	ClinGen gnomAD
rs759633424 CA9187199	39	G>D		No	ClinGen ExAC TOPMed gnomAD
CA305205327 rs1002809416	40	D>N		No	ClinGen TOPMed gnomAD
CA403963727 rs1002809416	40	D>Y		No	ClinGen TOPMed gnomAD
rs1599328115 CA403963715	41	T>P		No	ClinGen Ensembl
CA9187196 rs769413677	42	S>N		No	ClinGen ExAC TOPMed gnomAD
rs769413677 CA305205321	42	S>T		No	ClinGen ExAC TOPMed gnomAD
rs747937250 CA9187195 COSM990426	43	P>S	Variant assessed as Somatic; 0.0001019 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1340447989 COSM438454 CA403963664	45	P>S	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA9187192 rs768562211	49	P>L		No	ClinGen ExAC TOPMed gnomAD
CA305205309 rs746990697	50	G>A		No	ClinGen ExAC TOPMed
CA9187191 rs746990697	50	G>E		No	ClinGen ExAC TOPMed
CA403963538 rs1008182740	52	P>S		No	ClinGen TOPMed gnomAD
rs1008182740 CA305205174	52	P>T		No	ClinGen TOPMed gnomAD
rs772211774 CA305205170	54	P>L		No	ClinGen gnomAD
rs1405452039 CA403963457	59	V>F		No	ClinGen gnomAD
rs561775868 CA305205163	60	I>T		No	ClinGen Ensembl
rs559673267 CA9187159	60	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1568496688 CA403963414	62	G>E		No	ClinGen Ensembl
rs756945511 CA9187156	62	G>R		No	ClinGen ExAC gnomAD
rs1168670872 CA403963396	63	N>K		No	ClinGen gnomAD
CA9187154 rs748986834	66	T>I		No	ClinGen ExAC gnomAD
CA9187153 rs778239419	68	T>A		No	ClinGen ExAC gnomAD
rs11558269 CA9187152	68	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	71	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9187148 rs755499541	72	I>R		No	ClinGen ExAC TOPMed gnomAD
CA403963267 rs1208481936	73	D>N		No	ClinGen TOPMed
rs755089151 CA9187146	74	E>K		No	ClinGen ExAC gnomAD
CA403963215 rs1223660148	75	D>E		No	ClinGen gnomAD
rs199860167 CA305205101	75	D>Y		No	ClinGen gnomAD
rs1372003409 CA403963213	76	G>S		No	ClinGen TOPMed gnomAD
rs372087131 CA9187145	77	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA403963189 rs1454393897	77	K>R		No	ClinGen Ensembl
rs772919195 CA9187116	81	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1482321430 CA403963022	82	V>L		No	ClinGen TOPMed
CA9187115 rs145291485	83	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs145291485 CA9187114	83	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM3821829 CA403963006 rs1396801898	83	R>H	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA403962990 rs1156737494	84	T>I		No	ClinGen TOPMed
rs1287179891 CA403962980	85	F>C		No	ClinGen gnomAD
rs781583662 CA9187113	86	R>G		No	ClinGen ExAC gnomAD
rs1411002932 CA403962965	86	R>T		No	ClinGen TOPMed
CA9187111 rs747493599	87	I>M		No	ClinGen ExAC gnomAD
rs1395097243 CA403962954	87	I>V		No	ClinGen TOPMed gnomAD
rs780544207 CA9187110	89	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1164657255 CA403962907	90	R>L		No	ClinGen gnomAD
rs1164657255 CA403962912	90	R>Q		No	ClinGen gnomAD
CA9187109 rs368465202	90	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1352001803 CA403962882	94	K>R		No	ClinGen TOPMed
CA9187106 COSM1165917 rs757468530	96	V>A	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA403962845 rs1187915764	97	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA403962806 rs1599327584	100	K>Q		No	ClinGen Ensembl
CA305202576 rs370039447	106	G>R		No	ClinGen ESP TOPMed gnomAD
TCGA novel	108	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA403961832 rs1599326548	111	D>A		No	ClinGen Ensembl
CA9187043 rs771325052	111	D>E		No	ClinGen ExAC gnomAD
rs150720892 CA9187042	112	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA403961827 rs150720892	112	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1480390778 CA403961819	113	P>L		No	ClinGen gnomAD
CA305202553 rs961171414	113	P>T		No	ClinGen Ensembl
rs770821575	114	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs745645967 CA9187036	116	N>K		No	ClinGen ExAC gnomAD
rs781570961 CA9187037	116	N>S		No	ClinGen ExAC gnomAD
CA305202494 rs11558272	118	A>V		No	ClinGen Ensembl
CA403961749 rs1399258915	125	D>N		No	ClinGen gnomAD
rs763462020 CA9187030	127	S>P		No	ClinGen ExAC gnomAD
CA403961729 rs1334926711	128	M>V		No	ClinGen TOPMed gnomAD
CA9187029 rs369663424	129	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1378185125 CA403961710	130	F>L		No	ClinGen TOPMed gnomAD
CA305202429 rs201238271	131	I>L		No	ClinGen 1000Genomes
rs376758358 CA9187028	133	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA9187027 rs767148811	135	E>D		No	ClinGen ExAC TOPMed gnomAD
rs148192612 CA305202217	140	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9186997 rs775793343	141	E>A		No	ClinGen ExAC gnomAD
rs770564468 CA9186996	143	E>D		No	ClinGen ExAC gnomAD
CA403961595 rs1310154623	145	P>A		No	ClinGen TOPMed gnomAD
CA403961594 rs1310154623	145	P>S		No	ClinGen TOPMed gnomAD
CA403961596 rs1310154623	145	P>T		No	ClinGen TOPMed gnomAD
CA403961586 rs1481540735	146	M>T		No	ClinGen TOPMed
CA9186993 rs200494795	154	I>M		No	ClinGen ExAC TOPMed gnomAD
rs748121308 CA9186992	156	S>T		No	ClinGen ExAC gnomAD
CA403961442 rs1599326295	166	T>P		No	ClinGen Ensembl
CA9186985 rs765737865	175	L>Q		No	ClinGen ExAC gnomAD
CA403961371 rs1220045850	177	P>A		No	ClinGen gnomAD
TCGA novel	178	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs561764575 CA305202095	184	E>A		No	ClinGen 1000Genomes
rs1315028177 CA403961322	184	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA9186980 rs775495349	190	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1028007124 CA305202078	190	T>I		No	ClinGen Ensembl
CA9186979 COSM1390016 rs767761417	192	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1237541686	194	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9186978 rs759722830	194	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs772957450 CA9186977	197	P>L		No	ClinGen ExAC gnomAD
CA305202041 rs777497675	198	G>A		No	ClinGen Ensembl
TCGA novel	199	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs375316477 CA9186945	200	L>V		No	ClinGen ESP ExAC gnomAD
RCV000913601 CA9186944 rs374292482	201	E>D		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
CA403959780 rs1302395089	201	E>K		No	ClinGen gnomAD
CA403959740 rs1332905659	202	P>L		No	ClinGen TOPMed gnomAD
rs1375151515 CA403959749	202	P>S		No	ClinGen gnomAD
CA403959734 rs1404692026	203	V>M		No	ClinGen gnomAD
rs1286789938 CA403959710	204	Q>K		No	ClinGen gnomAD
CA403959698 rs1467510622	204	Q>R		No	ClinGen gnomAD
CA403959684 rs1599325427	205	A>T		No	ClinGen Ensembl
CA403959677 rs1378078000	205	A>V		No	ClinGen TOPMed gnomAD
rs1158298210 CA403959659	206	T>M		No	ClinGen TOPMed gnomAD
COSM990425 rs751709107 CA9186940	207	Q>H	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
TCGA novel	208	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs149009824 CA305201114	208	N>S		No	ClinGen ESP TOPMed gnomAD
rs766578639 CA9186939	210	T>A		No	ClinGen ExAC gnomAD
rs1599325399 CA403959575	211	G>E		No	ClinGen Ensembl
rs1198855120 CA403959578 CA403959580	211	G>R		No	ClinGen TOPMed gnomAD
rs530819290 CA305201084	215	P>L	Variant assessed as Somatic; 4.715e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA
TCGA novel	216	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA403959455 rs1240381943	217	S>R		No	ClinGen gnomAD
rs1374126172 CA403959447	218	L>V		No	ClinGen TOPMed
rs1331808070 CA403959428	219	R>C		No	ClinGen gnomAD
CA9186933 rs771542095	219	R>H		No	ClinGen ExAC gnomAD
rs1417843694 CA403959399	220	D>G		No	ClinGen gnomAD
rs770681828 CA9186930	220	D>N		No	ClinGen ExAC TOPMed gnomAD
CA9186928 rs778156862	221	G>R		No	ClinGen ExAC gnomAD
TCGA novel	222	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770074103 CA9186927	223	S>G		No	ClinGen ExAC TOPMed gnomAD
CA403959343 rs1368054693	223	S>N		No	ClinGen gnomAD
CA9186926 rs150270880	224	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs781549844 CA9186925	224	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA403959313 rs1216493558	225	R>C		No	ClinGen TOPMed gnomAD
rs1288585636 COSM710265 CA403959296	226	G>R	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA9186922 rs780148640	227	E>K		No	ClinGen ExAC TOPMed gnomAD
CA305200996 rs192366729	229	M>V		No	ClinGen 1000Genomes gnomAD
CA403959198 rs1246566846	230	Q>*		No	ClinGen gnomAD
rs758579235 CA9186921	233	R>C		No	ClinGen ExAC TOPMed gnomAD
rs750633234 CA9186920	233	R>H		No	ClinGen ExAC gnomAD
rs760391314 CA9186918	234	R>G		No	ClinGen ExAC gnomAD
CA403959102 rs1423685248	234	R>K		No	ClinGen gnomAD
TCGA novel	234	R>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752604243 CA9186917	235	A>S		No	ClinGen ExAC TOPMed gnomAD
rs1176370574 CA403958922	235	A>V		No	ClinGen gnomAD
CA403958916 rs1238246473	236	D>N		No	ClinGen gnomAD
CA403958862 rs1474749470	238	N>D		No	ClinGen gnomAD
rs758688972	238	N>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA403958854 rs1440200016	238	N>S		No	ClinGen TOPMed gnomAD
CA9186873 rs868284931	239	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1352688096 CA403958802	241	I>T		No	ClinGen gnomAD
CA403958673 rs1238245756	248	E>K		No	ClinGen gnomAD
CA9186871 rs766409457	249	D>N		No	ClinGen ExAC gnomAD
CA403958592 rs1359098788	251	R>C		No	ClinGen TOPMed
CA403958492 rs1360251968	256	Q>P		No	ClinGen gnomAD
rs1380470045 CA403958426	260	R>Q		No	ClinGen gnomAD
rs776280151 CA9186866	260	R>W		No	ClinGen ExAC gnomAD
CA403958371 rs1471496056	263	G>R		No	ClinGen TOPMed gnomAD
rs1471496056 CA403958374	263	G>S		No	ClinGen TOPMed gnomAD
CA305200659 rs200368684	265	I>F		No	ClinGen ExAC gnomAD
CA9186864 rs200368684	265	I>V		No	ClinGen ExAC gnomAD
rs775888897 CA9186863	268	I>N		No	ClinGen ExAC gnomAD
rs1199329621 CA403958206	272	K>N		No	ClinGen TOPMed
CA9186859 rs771061841	273	D>E		No	ClinGen ExAC TOPMed gnomAD
rs146486140 CA9186858	275	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9186857 rs146486140	275	T>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs770201819 CA9186856	277	G>S		No	ClinGen ExAC gnomAD
rs780039345	280	K>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA403957956 rs1404067111	285	I>T		No	ClinGen TOPMed
rs1298605563 CA403957944	286	S>N		No	ClinGen TOPMed
CA9186803 rs747730661	287	F>L		No	ClinGen ExAC gnomAD
rs1599324673 CA403957915	288	H>P		No	ClinGen Ensembl
rs780891354 CA9186802	288	H>Y		No	ClinGen ExAC gnomAD
rs754638574 CA9186801	289	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9186800 rs537564081	289	R>H		No	ClinGen 1000Genomes ExAC gnomAD
rs1481001310 CA403957894	290	R>C		No	ClinGen TOPMed gnomAD
TCGA novel	290	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1440416347 CA403957866	292	D>G		No	ClinGen gnomAD
rs750985061 CA9186797	292	D>N		No	ClinGen ExAC gnomAD
rs370696834 CA9186796	293	A>T		No	ClinGen ESP ExAC gnomAD
CA403957839 rs1238973948	294	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1311018702 CA403957838	295	R>C		No	ClinGen gnomAD
CA403957835 rs1391399171	295	R>H	Variant assessed as Somatic; 4.633e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA403957704 rs1599324606	307	H>P		No	ClinGen Ensembl
CA9186788 rs773137413	311	N>S		No	ClinGen ExAC gnomAD
rs780608878 CA9186785	313	E>K		No	ClinGen ExAC gnomAD
CA403957612 rs1216274159	315	A>T		No	ClinGen gnomAD
TCGA novel	317	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	317	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9186748 rs368352623	319	T>N		No	ClinGen ESP ExAC gnomAD
rs1303860087 CA403956649	320	N>K		No	ClinGen gnomAD
rs765039825 CA9186747	320	N>S		No	ClinGen ExAC gnomAD

No associated diseases with O75821

3 regional properties for O75821

Type	Name	Position	InterPro Accession
domain	RNA recognition motif domain	239 - 317	IPR000504
domain	Eukaryotic translation initiation factor 3 subunit G, N-terminal	59 - 175	IPR024675
domain	eIF3G, RNA recognition motif	240 - 315	IPR034240

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus Cytoplasm, perinuclear region	Colocalizes with AIFM1 in the nucleus and perinuclear region
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
eukaryotic 43S preinitiation complex	A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA.
eukaryotic 48S preinitiation complex	A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA.
eukaryotic translation initiation factor 3 complex	A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.

2 GO annotations of molecular function

Name	Definition
RNA binding	Binding to an RNA molecule or a portion thereof.
translation initiation factor activity	Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

3 GO annotations of biological process

Name	Definition
formation of cytoplasmic translation initiation complex	Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.
translational initiation	The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
viral translational termination-reinitiation	A process which occurs as part of viral mRNA translation which allows expression of a downstream open reading frame (ORF) in a dicistronic mRNA. In this process, ribosomes translate the upstream ORF but following termination, a proportion of 40S subunits remain tethered to the mRNA and go on to re-initiate translation at the start codon of the downstream ORF.

11 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q04067	TIF35	Eukaryotic translation initiation factor 3 subunit G	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q3ZC12	EIF3G	Eukaryotic translation initiation factor 3 subunit G	Bos taurus (Bovine)	PR
Q9VDM6	eIF3g2	Eukaryotic translation initiation factor 3 subunit G-2	Drosophila melanogaster (Fruit fly)	PR
Q9W4X7	eIF3g1	Eukaryotic translation initiation factor 3 subunit G-1	Drosophila melanogaster (Fruit fly)	PR
Q14576	ELAVL3	ELAV-like protein 3	Homo sapiens (Human)	PR
P26378	ELAVL4	ELAV-like protein 4	Homo sapiens (Human)	PR
Q12926	ELAVL2	ELAV-like protein 2	Homo sapiens (Human)	PR
Q9Z1D1	Eif3g	Eukaryotic translation initiation factor 3 subunit G	Mus musculus (Mouse)	PR
Q5RK09	Eif3g	Eukaryotic translation initiation factor 3 subunit G	Rattus norvegicus (Rat)	PR
Q19706	eif-3.G	Eukaryotic translation initiation factor 3 subunit G	Caenorhabditis elegans	PR
Q28CY2	eif3g	Eukaryotic translation initiation factor 3 subunit G	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MPTGDFDSKP	SWADQVEEEG	EDDKCVTSEL	LKGIPLATGD	TSPEPELLPG	APLPPPKEVI
70	80	90	100	110	120
NGNIKTVTEY	KIDEDGKKFK	IVRTFRIETR	KASKAVARRK	NWKKFGNSEF	DPPGPNVATT
130	140	150	160	170	180
TVSDDVSMTF	ITSKEDLNCQ	EEEDPMNKLK	GQKIVSCRIC	KGDHWTTRCP	YKDTLGPMQK
190	200	210	220	230	240
ELAEQLGLST	GEKEKLPGEL	EPVQATQNKT	GKYVPPSLRD	GASRRGESMQ	PNRRADDNAT
250	260	270	280	290	300
IRVTNLSEDT	RETDLQELFR	PFGSISRIYL	AKDKTTGQSK	GFAFISFHRR	EDAARAIAGV
310
SGFGYDHLIL	NVEWAKPSTN