Q2MKA5
PR
Gene name |
Chrna5 |
Protein name |
Neuronal acetylcholine receptor subunit alpha-5 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:110835 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2MKA5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2MKA5-F1 | Predicted | AlphaFoldDB |
21 variants for Q2MKA5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs227466429 | 49 | S>G | No | EVA | |
| rs260591225 | 60 | K>R | No | EVA | |
| rs215986618 | 74 | I>V | No | EVA | |
| rs3400253066 | 92 | L>E | No | EVA | |
| rs3399856615 | 122 | R>C | No | EVA | |
| rs3389053078 | 168 | S>I | No | EVA | |
| rs3389013871 | 210 | T>A | No | EVA | |
| rs3389040644 | 255 | L>P | No | EVA | |
| rs3389013856 | 259 | I>V | No | EVA | |
| rs3389048339 | 270 | V>I | No | EVA | |
| rs3388994158 | 353 | R>S | No | EVA | |
| rs236436625 | 381 | E>Q | No | EVA | |
| rs262595957 | 383 | D>G | No | EVA | |
| rs262595957 | 383 | D>V | No | EVA | |
| rs218313265 | 384 | G>S | No | EVA | |
| rs231045151 | 385 | G>E | No | EVA | |
| rs3412977888 | 393 | E>D | No | EVA | |
| rs3389053084 | 397 | D>V | No | EVA | |
| rs3389044700 | 398 | C>Y | No | EVA | |
| rs3388994169 | 452 | K>N | No | EVA | |
| rs3389047714 | 453 | W>C | No | EVA |
No associated diseases with Q2MKA5
13 regional properties for Q2MKA5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Clathrin, heavy chain/VPS, 7-fold repeat | 537 - 683 | IPR000547-1 |
| repeat | Clathrin, heavy chain/VPS, 7-fold repeat | 686 - 828 | IPR000547-2 |
| repeat | Clathrin, heavy chain/VPS, 7-fold repeat | 833 - 972 | IPR000547-3 |
| repeat | Clathrin, heavy chain/VPS, 7-fold repeat | 979 - 1124 | IPR000547-4 |
| repeat | Clathrin, heavy chain/VPS, 7-fold repeat | 1128 - 1269 | IPR000547-5 |
| repeat | Clathrin, heavy chain/VPS, 7-fold repeat | 1274 - 1420 | IPR000547-6 |
| repeat | Clathrin, heavy chain/VPS, 7-fold repeat | 1423 - 1582 | IPR000547-7 |
| domain | Clathrin, heavy chain, linker, core motif | 331 - 354 | IPR015348 |
| repeat | Clathrin, heavy chain, propeller repeat | 19 - 56 | IPR022365-1 |
| repeat | Clathrin, heavy chain, propeller repeat | 148 - 187 | IPR022365-2 |
| repeat | Clathrin, heavy chain, propeller repeat | 198 - 234 | IPR022365-3 |
| repeat | Clathrin, heavy chain, propeller repeat | 256 - 288 | IPR022365-4 |
| repeat | Clathrin, heavy chain, propeller repeat | 296 - 330 | IPR022365-5 |
10 GO annotations of cellular component
| Name | Definition |
|---|---|
| acetylcholine-gated channel complex | A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding. |
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| dopaminergic synapse | A synapse that uses dopamine as a neurotransmitter. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic membrane | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| acetylcholine binding | Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. |
| acetylcholine receptor activity | Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| acetylcholine-gated cation-selective channel activity | Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine. |
| excitatory extracellular ligand-gated ion channel activity | Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential. |
| neurotransmitter receptor activity | Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. |
| protein-containing complex binding | Binding to a macromolecular complex. |
| transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential. |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| behavioral response to nicotine | Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus. |
| cellular response to nicotine | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. |
| chemical synaptic transmission | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
| detection of mechanical stimulus involved in sensory perception of pain | The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal. |
| ion transmembrane transport | A process in which an ion is transported across a membrane. |
| membrane depolarization | The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential. |
| nervous system process | A organ system process carried out by any of the organs or tissues of neurological system. |
| regulation of membrane potential | Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. |
| regulation of neuronal action potential | Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. |
| regulation of synaptic vesicle exocytosis | Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis. |
| response to nicotine | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| synaptic transmission, cholinergic | The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
37 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q07263 | CHRNA3 | Neuronal acetylcholine receptor subunit alpha-3 | Bos taurus (Bovine) | PR |
| P04758 | CHRNB1 | Acetylcholine receptor subunit beta | Bos taurus (Bovine) | PR |
| Q8SPU7 | CHRNA5 | Neuronal acetylcholine receptor subunit alpha-5 | Bos taurus (Bovine) | PR |
| P09481 | CHRNA3 | Neuronal acetylcholine receptor subunit alpha-3 | Gallus gallus (Chicken) | PR |
| Q9I8C7 | CHRNA10 | Neuronal acetylcholine receptor subunit alpha-10 | Gallus gallus (Chicken) | PR |
| P43679 | CHRNB3 | Neuronal acetylcholine receptor subunit beta-3 | Gallus gallus (Chicken) | PR |
| P26152 | CHRNA5 | Neuronal acetylcholine receptor subunit alpha-5 | Gallus gallus (Chicken) | PR |
| Q5IS76 | CHRNA6 | Neuronal acetylcholine receptor subunit alpha-6 | Pan troglodytes (Chimpanzee) | PR |
| Q5IS75 | CHRNB3 | Neuronal acetylcholine receptor subunit beta-3 | Pan troglodytes (Chimpanzee) | PR |
| P25162 | nAChRbeta2 | Acetylcholine receptor subunit beta-like 2 | Drosophila melanogaster (Fruit fly) | PR |
| Q15825 | CHRNA6 | Neuronal acetylcholine receptor subunit alpha-6 | Homo sapiens (Human) | PR |
| Q05901 | CHRNB3 | Neuronal acetylcholine receptor subunit beta-3 | Homo sapiens (Human) | PR |
| P11230 | CHRNB1 | Acetylcholine receptor subunit beta | Homo sapiens (Human) | PR |
| P32297 | CHRNA3 | Neuronal acetylcholine receptor subunit alpha-3 | Homo sapiens (Human) | PR |
| P30532 | CHRNA5 | Neuronal acetylcholine receptor subunit alpha-5 | Homo sapiens (Human) | PR |
| P22723 | Gabrg2 | Gamma-aminobutyric acid receptor subunit gamma-2 | Mus musculus (Mouse) | PR |
| P62812 | Gabra1 | Gamma-aminobutyric acid receptor subunit alpha-1 | Mus musculus (Mouse) | PR |
| P22933 | Gabrd | Gamma-aminobutyric acid receptor subunit delta | Mus musculus (Mouse) | PR |
| P23979 | Htr3a | 5-hydroxytryptamine receptor 3A | Mus musculus (Mouse) | PR |
| P09690 | Chrnb1 | Acetylcholine receptor subunit beta | Mus musculus (Mouse) | PR |
| Q9R0W9 | Chrna6 | Neuronal acetylcholine receptor subunit alpha-6 | Mus musculus (Mouse) | PR |
| Q8BMN3 | Chrnb3 | Neuronal acetylcholine receptor subunit beta-3 | Mus musculus (Mouse) | PR |
| P04756 | Chrna1 | Acetylcholine receptor subunit alpha | Mus musculus (Mouse) | PR |
| P48168 | Glrb | Glycine receptor subunit beta | Mus musculus (Mouse) | PR |
| Q64018 | Glra1 | Glycine receptor subunit alpha-1 | Mus musculus (Mouse) | PR |
| Q91XP5 | Glra3 | Glycine receptor subunit alpha-3 | Mus musculus (Mouse) | PR |
| P43144 | Chrna9 | Neuronal acetylcholine receptor subunit alpha-9 | Rattus norvegicus (Rat) | PR |
| P35563 | Htr3a | 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Rat) | PR |
| P43143 | Chrna6 | Neuronal acetylcholine receptor subunit alpha-6 | Rattus norvegicus (Rat) | PR |
| P12391 | Chrnb3 | Neuronal acetylcholine receptor subunit beta-3 | Rattus norvegicus (Rat) | PR |
| P04757 | Chrna3 | Neuronal acetylcholine receptor subunit alpha-3 | Rattus norvegicus (Rat) | PR |
| P25109 | Chrnb1 | Acetylcholine receptor subunit beta | Rattus norvegicus (Rat) | PR |
| P25108 | Chrna1 | Acetylcholine receptor subunit alpha | Rattus norvegicus (Rat) | PR |
| P20420 | Chrna5 | Neuronal acetylcholine receptor subunit alpha-5 | Rattus norvegicus (Rat) | PR |
| P54244 | deg-3 | Acetylcholine receptor subunit alpha-type deg-3 | Caenorhabditis elegans | PR |
| P54246 | acr-5 | Acetylcholine receptor subunit alpha-type acr-5 | Caenorhabditis elegans | PR |
| Q93149 | acr-3 | Acetylcholine receptor subunit beta-type acr-3 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAARGSRRRA | LRLLLMVQLL | AGRWRPAGAA | RGARGGLPEL | SSAAKHEDSL | FRDLFEDYEK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WVRPVEHLSD | KIKIKFGLAI | SQLVDVDEKN | QLMTTNVWLK | QEWIDVKLRW | NPDDYGGIKI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IRVPSDSLWI | PDIVLFDNAD | GRFEGASTKT | VVRYNGTVTW | TQPANYKSSC | TIDVTFFPFD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LQNCSMKFGS | WTYDGSQVDI | ILEDQDVDRT | DFFDNGEWEI | MSAMGSKGNR | TDSCCWYPCI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TYSFVIKRLP | LFYTLFLIIP | CIGLSFLTVV | VFYLPSNEGE | KISLCTSVLV | SLTVFLLVIE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EIIPSSSKVI | PLIGEYLVFT | MIFVTLSIMV | TVFAINIHHR | SSSTHNAMAP | WVRKIFLHKL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PKLLCMRSHA | DRYFTQREEA | EKDGGPKSRN | TLEAALDCIR | YITRHVVKEN | DVREVVEDWK |
| 430 | 440 | 450 | 460 | ||
| FIAQVLDRMF | LWTFLLVSII | GTLGLFVPVI | YKWANIIVPV | HIGNTIK |