P09481

PR
Gene name
CHRNA3
Protein name
Neuronal acetylcholine receptor subunit alpha-3
Names
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:386578
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

319-455 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P09481

Entry ID Method Resolution Chain Position Source
AF-P09481-F1 Predicted AlphaFoldDB

1 variants for P09481

Variant ID(s) Position Change Description Diseaes Association Provenance
rs736698826 17 F>C No Ensembl

No associated diseases with P09481

3 regional properties for P09481

Type Name Position InterPro Accession
domain Neurotransmitter-gated ion-channel transmembrane domain 239 - 486 IPR006029
domain Neurotransmitter-gated ion-channel ligand-binding domain 26 - 231 IPR006202
conserved_site Neurotransmitter-gated ion-channel, conserved site 150 - 164 IPR018000

Functions

Description
EC Number
Subcellular Localization
  • Postsynaptic cell membrane; Multi-pass membrane protein
  • Cell membrane; Multi-pass membrane protein
  • Endoplasmic reticulum
  • Golgi apparatus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
acetylcholine-gated channel complex A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
postsynaptic membrane A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

5 GO annotations of molecular function

Name Definition
acetylcholine receptor activity Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
acetylcholine-gated cation-selective channel activity Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine.
excitatory extracellular ligand-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential.
neurotransmitter receptor activity Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity.
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.

9 GO annotations of biological process

Name Definition
behavioral response to nicotine Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus.
chemical synaptic transmission The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
ion transmembrane transport A process in which an ion is transported across a membrane.
membrane depolarization The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
nervous system process A organ system process carried out by any of the organs or tissues of neurological system.
regulation of membrane potential Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
synaptic transmission involved in micturition The process of communication from a neuron to a smooth muscle in the bladder that contributes to the expulsion of urine from the body.

32 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P04758 CHRNB1 Acetylcholine receptor subunit beta Bos taurus (Bovine) PR
Q8SPU7 CHRNA5 Neuronal acetylcholine receptor subunit alpha-5 Bos taurus (Bovine) PR
Q07263 CHRNA3 Neuronal acetylcholine receptor subunit alpha-3 Bos taurus (Bovine) PR
P19150 GABRA1 Gamma-aminobutyric acid receptor subunit alpha-1 Gallus gallus (Chicken) PR
Q9I8C7 CHRNA10 Neuronal acetylcholine receptor subunit alpha-10 Gallus gallus (Chicken) PR
P26152 CHRNA5 Neuronal acetylcholine receptor subunit alpha-5 Gallus gallus (Chicken) PR
P43679 CHRNB3 Neuronal acetylcholine receptor subunit beta-3 Gallus gallus (Chicken) PR
Q5IS76 CHRNA6 Neuronal acetylcholine receptor subunit alpha-6 Pan troglodytes (Chimpanzee) PR
Q5IS75 CHRNB3 Neuronal acetylcholine receptor subunit beta-3 Pan troglodytes (Chimpanzee) PR
P25162 nAChRbeta2 Acetylcholine receptor subunit beta-like 2 Drosophila melanogaster (Fruit fly) PR
Q15825 CHRNA6 Neuronal acetylcholine receptor subunit alpha-6 Homo sapiens (Human) PR
Q05901 CHRNB3 Neuronal acetylcholine receptor subunit beta-3 Homo sapiens (Human) PR
P30532 CHRNA5 Neuronal acetylcholine receptor subunit alpha-5 Homo sapiens (Human) PR
P11230 CHRNB1 Acetylcholine receptor subunit beta Homo sapiens (Human) PR
P32297 CHRNA3 Neuronal acetylcholine receptor subunit alpha-3 Homo sapiens (Human) PR
P23979 Htr3a 5-hydroxytryptamine receptor 3A Mus musculus (Mouse) PR
P04756 Chrna1 Acetylcholine receptor subunit alpha Mus musculus (Mouse) PR
Q9R0W9 Chrna6 Neuronal acetylcholine receptor subunit alpha-6 Mus musculus (Mouse) PR
P09690 Chrnb1 Acetylcholine receptor subunit beta Mus musculus (Mouse) PR
Q8BMN3 Chrnb3 Neuronal acetylcholine receptor subunit beta-3 Mus musculus (Mouse) PR
Q2MKA5 Chrna5 Neuronal acetylcholine receptor subunit alpha-5 Mus musculus (Mouse) PR
P43144 Chrna9 Neuronal acetylcholine receptor subunit alpha-9 Rattus norvegicus (Rat) PR
P35563 Htr3a 5-hydroxytryptamine receptor 3A Rattus norvegicus (Rat) PR
P43143 Chrna6 Neuronal acetylcholine receptor subunit alpha-6 Rattus norvegicus (Rat) PR
P12391 Chrnb3 Neuronal acetylcholine receptor subunit beta-3 Rattus norvegicus (Rat) PR
P25109 Chrnb1 Acetylcholine receptor subunit beta Rattus norvegicus (Rat) PR
P25108 Chrna1 Acetylcholine receptor subunit alpha Rattus norvegicus (Rat) PR
P20420 Chrna5 Neuronal acetylcholine receptor subunit alpha-5 Rattus norvegicus (Rat) PR
P04757 Chrna3 Neuronal acetylcholine receptor subunit alpha-3 Rattus norvegicus (Rat) PR
P54244 deg-3 Acetylcholine receptor subunit alpha-type deg-3 Caenorhabditis elegans PR
P54246 acr-5 Acetylcholine receptor subunit alpha-type acr-5 Caenorhabditis elegans PR
Q93149 acr-3 Acetylcholine receptor subunit beta-type acr-3 Caenorhabditis elegans PR
10 20 30 40 50 60
MQSIHALLLT AAVCILFQGC GGSEPEHRLY AALFKNYNQF VRPVKNASDP VIIQFEVSMS
70 80 90 100 110 120
QLVKVDEVNQ IMETNLWLKH IWNDYKLRWN PVDYGGAEFI RVPSGQIWKP DIVLYNNAVG
130 140 150 160 170 180
DFQVDDKTKA LLKYTGDVTW IPPAIFKSSC KIDVTYFPFD YQNCTMKFGS WSYDKAKIDL
190 200 210 220 230 240
VLIGSTMNLK DYWESGEWAI IKAPGYKHDI KYNCCEEIYT DITYSLYIRR LPLFYTINMI
250 260 270 280 290 300
IPCLLISFLT VLVFYLPSDC GEKVTLCISV LLSLTVFLLV ITETIPSTSL VIPLIGEYLL
310 320 330 340 350 360
FTMIFVTLSI VITVFVLNVH YRTPKTHTMP VWVRTIFLNL LPRIMFMTRP TSDEENNQKP
370 380 390 400 410 420
KPFYTSEFSN LNCFNSSEIK CCKDGFVCQD MACSCCQYQR MKFSDFSGNL TRSSSSESVD
430 440 450 460 470 480
PLFSFSVLSP EMRDAIESVK YIAENMKMQN EAKEIQDDWK YVAMVIDRIF LWVFILVCIL
490
GTAGLFLQPL MTGDDM