P04758

PR
Gene name
CHRNB1
Protein name
Acetylcholine receptor subunit beta
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:282179
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-61 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P04758

Entry ID Method Resolution Chain Position Source
AF-P04758-F1 Predicted AlphaFoldDB

127 variants for P04758

Variant ID(s) Position Change Description Diseaes Association Provenance
rs469848233 2 T>N No EVA
rs449264768 3 P>Q No EVA
rs434765365 4 G>W No EVA
rs451709604 7 L>I No EVA
rs465663453 7 L>P No EVA
rs465663453 7 L>R No EVA
rs437534053 9 L>I No EVA
rs457638163 9 L>P No EVA
rs474347104 10 L>P No EVA
rs474347104 10 L>R No EVA
rs455310097 11 L>M No EVA
rs472364029 11 L>R No EVA
rs457623319 13 V>G No EVA
rs440771212 13 V>L No EVA
rs443440030 20 P>Q No EVA
rs443201065 22 A>S No EVA
rs474156900 27 A>G No EVA
rs442591509 28 E>G No EVA
rs459590327 29 G>A No EVA
rs459590327 29 G>V No EVA
rs459054258 31 L>P No EVA
rs450951442 32 R>P No EVA
rs436733447 33 E>D No EVA
rs468023470 33 E>G No EVA
rs446992933 35 L>I No EVA
rs467148049 37 S>* No EVA
rs471346437 43 V>G No EVA
rs436738279 44 R>P No EVA
rs456822166 45 P>T No EVA
rs474100672 46 A>G No EVA
rs442673645 49 V>G No EVA
rs438630183 55 V>G No EVA
rs459015575 64 L>F No EVA
rs473207180 83 E>A No EVA
rs459060921 114 V>G No EVA
rs436764092 121 D>E No EVA
rs456923063 129 D>E No EVA
rs436232621 132 V>A No EVA
rs473168631 137 D>A No EVA
rs438636021 140 M>K No EVA
rs452613698 152 C>G No EVA
rs475936055 152 C>S No EVA
rs444420735 155 Q>* No EVA
rs461347996 155 Q>H No EVA
rs476802706 161 F>V No EVA
rs460983607 175 Y>C No EVA
rs440022174 176 D>E No EVA
rs481161579 176 D>Y No EVA
rs460094200 179 E>D No EVA
rs477001978 180 V>A No EVA
rs482866625 188 P>S No EVA
rs448314087 193 R>G No EVA
rs448314087 193 R>W No EVA
rs468496180 194 Q>E No EVA
rs434010462 194 Q>P No EVA
rs454078603 195 E>G No EVA
rs456764137 196 V>E No EVA
rs456764137 196 V>G No EVA
rs433188666 196 V>M No EVA
rs455971279 197 Y>* No EVA
rs476968326 197 Y>D No EVA
rs442190714 197 Y>F No EVA
rs476968326 197 Y>N No EVA
rs440085802 199 H>L No EVA
rs440085802 199 H>P No EVA
rs472797236 199 H>Y No EVA
rs460250199 200 E>D No EVA
rs439214893 202 T>A No EVA
rs439214893 202 T>P No EVA
rs483006713 203 F>L No EVA
rs448292221 204 I>F No EVA
rs448292221 204 I>V No EVA
rs468156617 205 E>* No EVA
rs449347713 217 R>W No EVA
rs461649845 220 Q>* No EVA
rs445563103 227 G>* No EVA
rs465545346 228 G>D No EVA
rs456196502 234 E>A No EVA
rs469896834 235 E>D No EVA
rs480237447 239 Y>S No EVA
rs441021670 274 A>G No EVA
rs472015532 274 A>S No EVA
rs454897843 299 V>I No EVA
rs433984164 300 P>S No EVA
rs454319604 329 V>A No EVA
rs476016102 351 F>L No EVA
rs441841044 354 K>N No EVA
rs455492046 355 L>F No EVA
rs472417153 356 P>H No EVA
rs441024411 359 L>M No EVA
rs478391060 362 K>* No EVA
rs463707106 367 E>A No EVA
rs480628519 368 R>T No EVA
rs449587372 369 D>A No EVA
rs466452183 369 D>E No EVA
rs449587372 369 D>G No EVA
rs480047003 373 E>K No EVA
rs465582356 378 A>S No EVA
rs432830024 380 R>S No EVA
rs435191571 385 S>R No EVA
rs440983106 391 T>I No EVA
rs440983106 391 T>K No EVA
rs471612341 392 D>E No EVA
rs443717044 393 E>* No EVA
rs474171035 393 E>D No EVA
rs463885139 393 E>G No EVA
rs443717044 393 E>K No EVA
rs442891354 394 Y>F No EVA
rs442891354 394 Y>S No EVA
rs480127437 395 F>S No EVA
rs460042342 395 F>V No EVA
rs459053003 396 I>F No EVA
rs459053003 396 I>L No EVA
rs482241576 396 I>N No EVA
rs482241576 396 I>T No EVA
rs469737834 397 R>H No EVA
rs469737834 397 R>P No EVA
rs448837758 398 K>R No EVA
rs465788548 399 P>T No EVA
rs434633842 404 L>P No EVA
rs451605301 405 F>S No EVA
rs471557627 409 N>H No EVA
rs440736473 411 F>Y No EVA
rs459347841 438 R>L No EVA
rs477860199 441 V>L No EVA
rs136646759 472 D>A No EVA
rs465322505 492 L>R No EVA

No associated diseases with P04758

3 regional properties for P04758

Type Name Position InterPro Accession
domain Neurotransmitter-gated ion-channel transmembrane domain 253 - 491 IPR006029
domain Neurotransmitter-gated ion-channel ligand-binding domain 29 - 246 IPR006202
conserved_site Neurotransmitter-gated ion-channel, conserved site 152 - 166 IPR018000

Functions

Description
EC Number
Subcellular Localization
  • Postsynaptic cell membrane; Multi-pass membrane protein
  • Cell membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
acetylcholine-gated channel complex A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of postsynaptic specialization membrane The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
neuromuscular junction The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

7 GO annotations of molecular function

Name Definition
acetylcholine binding Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions.
acetylcholine receptor activity Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
acetylcholine-gated cation-selective channel activity Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine.
channel activity Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.
excitatory extracellular ligand-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential.
neurotransmitter receptor activity Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity.
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.

12 GO annotations of biological process

Name Definition
behavioral response to nicotine Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus.
cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
chemical synaptic transmission The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
ion transmembrane transport A process in which an ion is transported across a membrane.
muscle cell development The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate.
muscle contraction A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
nervous system process A organ system process carried out by any of the organs or tissues of neurological system.
neuromuscular synaptic transmission The process of synaptic transmission from a neuron to a muscle, across a synapse.
postsynaptic membrane organization A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).
regulation of membrane potential Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
synaptic transmission, cholinergic The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.

34 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8SPU7 CHRNA5 Neuronal acetylcholine receptor subunit alpha-5 Bos taurus (Bovine) PR
P08219 GABRA1 Gamma-aminobutyric acid receptor subunit alpha-1 Bos taurus (Bovine) PR
Q07263 CHRNA3 Neuronal acetylcholine receptor subunit alpha-3 Bos taurus (Bovine) PR
Q9GJS9 GLRB Glycine receptor subunit beta Bos taurus (Bovine) PR
P57695 GLRA1 Glycine receptor subunit alpha-1 Bos taurus (Bovine) PR
P09481 CHRNA3 Neuronal acetylcholine receptor subunit alpha-3 Gallus gallus (Chicken) PR
P26152 CHRNA5 Neuronal acetylcholine receptor subunit alpha-5 Gallus gallus (Chicken) PR
Q9I8C7 CHRNA10 Neuronal acetylcholine receptor subunit alpha-10 Gallus gallus (Chicken) PR
P43679 CHRNB3 Neuronal acetylcholine receptor subunit beta-3 Gallus gallus (Chicken) PR
Q5IS76 CHRNA6 Neuronal acetylcholine receptor subunit alpha-6 Pan troglodytes (Chimpanzee) PR
Q5IS75 CHRNB3 Neuronal acetylcholine receptor subunit beta-3 Pan troglodytes (Chimpanzee) PR
P25162 nAChRbeta2 Acetylcholine receptor subunit beta-like 2 Drosophila melanogaster (Fruit fly) PR
Q15825 CHRNA6 Neuronal acetylcholine receptor subunit alpha-6 Homo sapiens (Human) PR
Q05901 CHRNB3 Neuronal acetylcholine receptor subunit beta-3 Homo sapiens (Human) PR
P30532 CHRNA5 Neuronal acetylcholine receptor subunit alpha-5 Homo sapiens (Human) PR
P32297 CHRNA3 Neuronal acetylcholine receptor subunit alpha-3 Homo sapiens (Human) PR
P11230 CHRNB1 Acetylcholine receptor subunit beta Homo sapiens (Human) PR
P23979 Htr3a 5-hydroxytryptamine receptor 3A Mus musculus (Mouse) PR
P04756 Chrna1 Acetylcholine receptor subunit alpha Mus musculus (Mouse) PR
Q9R0W9 Chrna6 Neuronal acetylcholine receptor subunit alpha-6 Mus musculus (Mouse) PR
Q8BMN3 Chrnb3 Neuronal acetylcholine receptor subunit beta-3 Mus musculus (Mouse) PR
Q2MKA5 Chrna5 Neuronal acetylcholine receptor subunit alpha-5 Mus musculus (Mouse) PR
P09690 Chrnb1 Acetylcholine receptor subunit beta Mus musculus (Mouse) PR
P43144 Chrna9 Neuronal acetylcholine receptor subunit alpha-9 Rattus norvegicus (Rat) PR
P35563 Htr3a 5-hydroxytryptamine receptor 3A Rattus norvegicus (Rat) PR
P43143 Chrna6 Neuronal acetylcholine receptor subunit alpha-6 Rattus norvegicus (Rat) PR
P12391 Chrnb3 Neuronal acetylcholine receptor subunit beta-3 Rattus norvegicus (Rat) PR
P04757 Chrna3 Neuronal acetylcholine receptor subunit alpha-3 Rattus norvegicus (Rat) PR
P25108 Chrna1 Acetylcholine receptor subunit alpha Rattus norvegicus (Rat) PR
P20420 Chrna5 Neuronal acetylcholine receptor subunit alpha-5 Rattus norvegicus (Rat) PR
P25109 Chrnb1 Acetylcholine receptor subunit beta Rattus norvegicus (Rat) PR
P54244 deg-3 Acetylcholine receptor subunit alpha-type deg-3 Caenorhabditis elegans PR
P54246 acr-5 Acetylcholine receptor subunit alpha-type acr-5 Caenorhabditis elegans PR
Q93149 acr-3 Acetylcholine receptor subunit beta-type acr-3 Caenorhabditis elegans PR
10 20 30 40 50 60
MTPGALLLLL LGVLGAHLAP GARGSEAEGR LREKLFSGYD STVRPAREVG DRVWVSIGLT
70 80 90 100 110 120
LAQLISLNEK DEEMSTKVYL DLEWTDYRLS WDPEEHEGID SLRISAESVW LPDVVLLNNN
130 140 150 160 170 180
DGNFDVALDI NVVVSSDGSM RWQPPGIYRS SCSIQVTYFP FDWQNCTMVF SSYSYDSSEV
190 200 210 220 230 240
SLQTGLSPEG QERQEVYIHE GTFIENGQWE IIHKPSRLIQ PSVDPRGGGE GRREEVTFYL
250 260 270 280 290 300
IIRRKPLFYL VNVIAPCILI TLLAIFVFYL PPDAGEKMGL SIFALLTLTV FLLLLADKVP
310 320 330 340 350 360
ETSLSVPIII KYLMFTMVLV TFSVILSVVV LNLHHRSPHT HQMPLWVRQI FIHKLPLYLG
370 380 390 400 410 420
LKRPKPERDQ MQEPPSIAPR DSPGSGWGRG TDEYFIRKPP NDFLFPKPNR FQPELSAPDL
430 440 450 460 470 480
RRFIDGPNRA VGLPPELREV VSSISYIARQ LQEQEDHDVL KEDWQFVAMV VDRLFLWTFI
490 500
IFTSVGTLVI FLDATYHLPP ADPFP