Q9GJS9
PR
Gene name |
GLRB |
Protein name |
Glycine receptor subunit beta |
Names |
Glycine receptor 58 kDa subunit |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:281198 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9GJS9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9GJS9-F1 | Predicted | AlphaFoldDB |
20 variants for Q9GJS9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs798492557 | 14 | S>P | No | EVA | |
| rs443594189 | 94 | I>N | No | EVA | |
| rs482651891 | 131 | D>A | No | EVA | |
| rs462495308 | 131 | D>E | No | EVA | |
| rs439202900 | 137 | C>W | No | EVA | |
| rs477059367 | 145 | F>Y | No | EVA | |
| rs452377717 | 177 | L>* | No | EVA | |
| rs432358878 | 197 | C>Y | No | EVA | |
| rs466897538 | 198 | K>N | No | EVA | |
| rs475672806 | 252 | Y>D | No | EVA | |
| rs475672806 | 252 | Y>N | No | EVA | |
| rs452234488 | 255 | C>S | No | EVA | |
| rs432211013 | 297 | A>D | No | EVA | |
| rs520737186 | 309 | L>V | No | EVA | |
| rs876515043 | 314 | T>P | No | EVA | |
| rs876368962 | 315 | T>P | No | EVA | |
| rs447522992 | 383 | K>E | No | EVA | |
| rs1117443670 | 407 | K>R | No | EVA | |
| rs444227188 | 408 | V>A | No | EVA | |
| rs109860488 | 465 | V>I | No | EVA |
No associated diseases with Q9GJS9
5 regional properties for Q9GJS9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Neurotransmitter-gated ion-channel transmembrane domain | 273 - 493 | IPR006029 |
| domain | Neurotransmitter-gated ion-channel ligand-binding domain | 57 - 265 | IPR006202 |
| conserved_site | Neurotransmitter-gated ion-channel, conserved site | 183 - 197 | IPR018000 |
| domain | Glycine receptor subunit beta, transmembrane domain | 268 - 496 | IPR047029 |
| domain | Glycine receptor subunit beta, extracellular domain | 79 - 265 | IPR047031 |
Functions
10 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| GABA-ergic synapse | A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory. |
| glycine-gated chloride channel complex | A protein complex that forms a transmembrane channel through which chloride ions may pass in response to glycine binding to the channel complex or one of its constituent parts. |
| glycinergic synapse | A synapse that uses glycine as a neurotransmitter. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| postsynaptic membrane | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| excitatory extracellular ligand-gated ion channel activity | Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential. |
| extracellularly glycine-gated chloride channel activity | Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. |
| extracellularly glycine-gated ion channel activity | Enables the transmembrane transfer of an ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. |
| glycine binding | Binding to glycine, aminoethanoic acid. |
| neurotransmitter receptor activity | Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. |
| transmembrane signaling receptor activity | Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. |
| transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential. |
17 GO annotations of biological process
| Name | Definition |
|---|---|
| acrosome reaction | The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida. |
| adult walking behavior | The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg. |
| chemical synaptic transmission | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
| chloride transmembrane transport | The process in which chloride is transported across a membrane. |
| gamma-aminobutyric acid receptor clustering | The receptor clustering process in which gamma-aminobutyric acid (GABA) receptors are localized to distinct domains in the cell membrane. |
| ion transmembrane transport | A process in which an ion is transported across a membrane. |
| ion transport | The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| nervous system process | A organ system process carried out by any of the organs or tissues of neurological system. |
| neuropeptide signaling pathway | A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. |
| regulation of membrane potential | Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. |
| response to amino acid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. |
| righting reflex | A reflex process in which an animal immediately tries to turn over after being placed in a supine position. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| startle response | An action or movement due to the application of a sudden unexpected stimulus. |
| synaptic transmission, glycinergic | The vesicular release of glycine from a presynapse, across a chemical synapse, the subsequent activation of glycine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
| visual perception | The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. |
19 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P57695 | GLRA1 | Glycine receptor subunit alpha-1 | Bos taurus (Bovine) | PR |
| P08219 | GABRA1 | Gamma-aminobutyric acid receptor subunit alpha-1 | Bos taurus (Bovine) | PR |
| P04758 | CHRNB1 | Acetylcholine receptor subunit beta | Bos taurus (Bovine) | PR |
| Q8SPU7 | CHRNA5 | Neuronal acetylcholine receptor subunit alpha-5 | Bos taurus (Bovine) | PR |
| Q07263 | CHRNA3 | Neuronal acetylcholine receptor subunit alpha-3 | Bos taurus (Bovine) | PR |
| Q94900 | GluClalpha | Glutamate-gated chloride channel | Drosophila melanogaster (Fruit fly) | PR |
| O75311 | GLRA3 | Glycine receptor subunit alpha-3 | Homo sapiens (Human) | PR |
| P23415 | GLRA1 | Glycine receptor subunit alpha-1 | Homo sapiens (Human) | PR |
| P48167 | GLRB | Glycine receptor subunit beta | Homo sapiens (Human) | PR |
| Q91XP5 | Glra3 | Glycine receptor subunit alpha-3 | Mus musculus (Mouse) | PR |
| Q64018 | Glra1 | Glycine receptor subunit alpha-1 | Mus musculus (Mouse) | PR |
| P48168 | Glrb | Glycine receptor subunit beta | Mus musculus (Mouse) | PR |
| P07727 | Glra1 | Glycine receptor subunit alpha-1 | Rattus norvegicus (Rat) | PR |
| P24524 | Glra3 | Glycine receptor subunit alpha-3 | Rattus norvegicus (Rat) | PR |
| P20781 | Glrb | Glycine receptor subunit beta | Rattus norvegicus (Rat) | PR |
| Q09453 | ggr-1 | Glycine receptor subunit beta-type 4 | Caenorhabditis elegans | PR |
| P41849 | lgc-50 | Ligand-gated ion channel 50 | Caenorhabditis elegans | PR |
| Q17328 | glc-2 | Glutamate-gated chloride channel subunit beta | Caenorhabditis elegans | PR |
| O93430 | glra1 | Glycine receptor subunit alphaZ1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKFLLAVAFF | ILISLCIEEA | YSKEKSSKKG | KGKKKQYLCP | SQQSAEDLAR | VPANSTSNIL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NRLLVSYDPR | IRPNFKGIPV | DVVVNIFINS | FGSIQETTMD | YRVNIFLRQK | WNDPRLKLPS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DFRGSDALTV | DPTMYKCLWK | PDLFFANEKS | ANFHDVTQEN | ILLFIFRDGD | VLVSMRLSIT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LSCPLDLTLF | PMDTQRCKMQ | LESFGYTTDD | LRFIWQSGDP | VQLEKIALPQ | FDIKKEDIEY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GNCTKYYKGT | GYYTCVEVIF | TLRRQVGFYM | MGVYAPTLLI | VVLSWLSFWI | NPDASAARVP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LGIFSVLSLA | SECTTLAAEL | PKVSYVKALD | VWLIACLLFG | FASLVEYAVV | QVMLNNPKRV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EAEKARIAKA | EQAVGKGGNV | AKKNTVNGAS | TPVHISTLQV | GETRCKKVCT | SKSDLRSNDF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SIVGSLPRDF | ELSNYDCYGK | PIEVNNGLGK | SQAKNNKKPP | PAKPVIPTAA | KRIDLYARAL |
| 490 | |||||
| FPFCFLFFNV | IYWSIYL |