Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for P48168

Entry ID Method Resolution Chain Position Source
AF-P48168-F1 Predicted AlphaFoldDB

26 variants for P48168

Variant ID(s) Position Change Description Diseaes Association Provenance
rs248648792 16 L>F No EVA
rs226462039 19 D>E No EVA
rs253857713 22 A>S No EVA
rs3388635425 25 K>Q No EVA
rs3388625408 69 P>S No EVA
74 N>TTMLDIQPMI spastic 1 [UniProt] No
rs3388633339 79 P>L No EVA
84 V>del spastic 1 [UniProt] No
143 L>VSMSWIYNR spastic 2 [UniProt] No
152 N>del spastic 2 [UniProt] No
rs3388633352 160 N>I No EVA
rs3388628231 179 I>V No EVA
rs3388635659 256 V>E No EVA
rs1131711398 258 V>D No EVA
rs1135312993 259 I>N No EVA
rs3388635630 259 I>V No EVA
rs1132895304 260 F>L No EVA
rs3388635678 288 F>L No EVA
rs3393260422 297 A>S No EVA
rs3388624955 345 V>L No EVA
rs3388633358 348 A>T No EVA
rs3393355421 349 V>G No EVA
rs3388636064 361 E>V No EVA
rs3388628228 380 A>E No EVA
rs3388636050 381 A>V No EVA
rs3388632221 469 A>G No EVA

1 associated diseases with P48168

Without disease ID

5 regional properties for P48168

Type Name Position InterPro Accession
domain Neurotransmitter-gated ion-channel transmembrane domain 273 - 492 IPR006029
domain Neurotransmitter-gated ion-channel ligand-binding domain 57 - 265 IPR006202
conserved_site Neurotransmitter-gated ion-channel, conserved site 183 - 197 IPR018000
domain Glycine receptor subunit beta, transmembrane domain 268 - 495 IPR047029
domain Glycine receptor subunit beta, extracellular domain 79 - 265 IPR047031

Functions

Description
EC Number
Subcellular Localization
  • Postsynaptic cell membrane ; Multi-pass membrane protein
  • Synapse
  • Cell projection, dendrite
  • Cell membrane ; Multi-pass membrane protein
  • Cytoplasm
  • Retained in the cytoplasm upon heterologous expression by itself
  • Coexpression with GPHN promotes expression at the cell membrane
  • Coexpression with GLRA1, GLRA2 or GLRA3 promotes expression at the cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

12 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
external side of plasma membrane The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
GABA-ergic synapse A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
glycine-gated chloride channel complex A protein complex that forms a transmembrane channel through which chloride ions may pass in response to glycine binding to the channel complex or one of its constituent parts.
glycinergic synapse A synapse that uses glycine as a neurotransmitter.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
postsynaptic membrane A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

8 GO annotations of molecular function

Name Definition
excitatory extracellular ligand-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential.
extracellularly glycine-gated chloride channel activity Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
extracellularly glycine-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
glycine binding Binding to glycine, aminoethanoic acid.
neurotransmitter receptor activity Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity.
protein-containing complex binding Binding to a macromolecular complex.
transmembrane signaling receptor activity Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.

18 GO annotations of biological process

Name Definition
acrosome reaction The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida.
adult walking behavior The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.
chemical synaptic transmission The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
chloride transmembrane transport The process in which chloride is transported across a membrane.
gamma-aminobutyric acid receptor clustering The receptor clustering process in which gamma-aminobutyric acid (GABA) receptors are localized to distinct domains in the cell membrane.
ion transmembrane transport A process in which an ion is transported across a membrane.
ion transport The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
nervous system process A organ system process carried out by any of the organs or tissues of neurological system.
neuromuscular process Any process pertaining to the functions of the nervous and muscular systems of an organism.
neuropeptide signaling pathway A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
regulation of membrane potential Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
response to amino acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
righting reflex A reflex process in which an animal immediately tries to turn over after being placed in a supine position.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
startle response An action or movement due to the application of a sudden unexpected stimulus.
synaptic transmission, glycinergic The vesicular release of glycine from a presynapse, across a chemical synapse, the subsequent activation of glycine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
visual perception The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.

24 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P57695 GLRA1 Glycine receptor subunit alpha-1 Bos taurus (Bovine) PR
Q9GJS9 GLRB Glycine receptor subunit beta Bos taurus (Bovine) PR
Q94900 GluClalpha Glutamate-gated chloride channel Drosophila melanogaster (Fruit fly) PR
O75311 GLRA3 Glycine receptor subunit alpha-3 Homo sapiens (Human) PR
P23415 GLRA1 Glycine receptor subunit alpha-1 Homo sapiens (Human) PR
P48167 GLRB Glycine receptor subunit beta Homo sapiens (Human) PR
Q91XP5 Glra3 Glycine receptor subunit alpha-3 Mus musculus (Mouse) PR
P62812 Gabra1 Gamma-aminobutyric acid receptor subunit alpha-1 Mus musculus (Mouse) PR
P22933 Gabrd Gamma-aminobutyric acid receptor subunit delta Mus musculus (Mouse) PR
P22723 Gabrg2 Gamma-aminobutyric acid receptor subunit gamma-2 Mus musculus (Mouse) PR
P23979 Htr3a 5-hydroxytryptamine receptor 3A Mus musculus (Mouse) PR
P09690 Chrnb1 Acetylcholine receptor subunit beta Mus musculus (Mouse) PR
Q9R0W9 Chrna6 Neuronal acetylcholine receptor subunit alpha-6 Mus musculus (Mouse) PR
Q8BMN3 Chrnb3 Neuronal acetylcholine receptor subunit beta-3 Mus musculus (Mouse) PR
Q2MKA5 Chrna5 Neuronal acetylcholine receptor subunit alpha-5 Mus musculus (Mouse) PR
P04756 Chrna1 Acetylcholine receptor subunit alpha Mus musculus (Mouse) PR
Q64018 Glra1 Glycine receptor subunit alpha-1 Mus musculus (Mouse) PR
P07727 Glra1 Glycine receptor subunit alpha-1 Rattus norvegicus (Rat) PR
P24524 Glra3 Glycine receptor subunit alpha-3 Rattus norvegicus (Rat) PR
P20781 Glrb Glycine receptor subunit beta Rattus norvegicus (Rat) PR
Q09453 ggr-1 Glycine receptor subunit beta-type 4 Caenorhabditis elegans PR
P41849 lgc-50 Ligand-gated ion channel 50 Caenorhabditis elegans PR
Q17328 glc-2 Glutamate-gated chloride channel subunit beta Caenorhabditis elegans PR
O93430 glra1 Glycine receptor subunit alphaZ1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MKFSLAISFF ILMSLLFEDA CAKEKSSKKG KGKKKQYLCP SQQSPEDLAR VPPNSTSNIL
70 80 90 100 110 120
NRLLVSYDPR IRPNFKGIPV DVVVNIFINS FGSIQETTMD YRVNIFLRQK WNDPRLKLPS
130 140 150 160 170 180
DFRGSDALTV DPTMYKCLWK PDLFFANEKS ANFHDVTQEN ILLFIFRDGD VLVSMRLSIT
190 200 210 220 230 240
LSCPLDLTLF PMDTQRCKMQ LESFGYTTDD LRFIWQSGDP VQLEKIALPQ FDIKKEDIEY
250 260 270 280 290 300
GNCTKYYKGT GYYTCVEVIF TLRRQVGFYM MGVYAPTLLI VVLSWLSFWI NPDASAARVP
310 320 330 340 350 360
LGIFSVLSLA SECTTLAAEL PKVSYVKALD VWLIACLLFG FASLVEYAVV QVMLNNPKRV
370 380 390 400 410 420
EAEKARIAKA EQADGKGGNA AKKNTVNGTG TPVHISTLQV GETRCKKVCT SKSDLRSNDF
430 440 450 460 470 480
SIVGSLPRDF ELSNYDCYGK PIEVNNGLGK PQAKNKKPPP AKPVIPTAAK RIDLYARALF
490
PFCFLFFNVI YWSIYL