P62812
PR
Gene name |
Gabra1 (Gabra-1) |
Protein name |
Gamma-aminobutyric acid receptor subunit alpha-1 |
Names |
GABA(A) receptor subunit alpha-1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:14394 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
11 structures for P62812
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5OSA | X-ray | 275 A | PDB | ||
| 5OSB | X-ray | 380 A | PDB | ||
| 5OSC | X-ray | 310 A | PDB | ||
| 8FOI | EM | 250 A | A/C | 1-455 | PDB |
| 8G4N | EM | 267 A | A/C | 1-455 | PDB |
| 8G4O | EM | 306 A | A/C | 1-455 | PDB |
| 8G4X | EM | 256 A | A | 1-455 | PDB |
| 8G5F | EM | 264 A | C | 1-455 | PDB |
| 8G5G | EM | 294 A | A | 1-455 | PDB |
| 8G5H | EM | 289 A | C | 1-455 | PDB |
| AF-P62812-F1 | Predicted | AlphaFoldDB |
8 variants for P62812
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389156019 | 226 | S>C | No | EVA | |
| rs3389145552 | 255 | Q>* | No | EVA | |
| rs3412691987 | 257 | Y>C | No | EVA | |
| rs3389160095 | 283 | V>I | No | EVA | |
| rs3389143584 | 290 | L>P | No | EVA | |
| rs3389156017 | 302 | S>F | No | EVA | |
| rs3389148345 | 407 | E>D | No | EVA | |
| rs3389122083 | 422 | S>T | No | EVA |
No associated diseases with P62812
5 regional properties for P62812
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Neurotransmitter-gated ion-channel transmembrane domain | 256 - 340 | IPR006029 |
| domain | Neurotransmitter-gated ion-channel ligand-binding domain | 42 - 249 | IPR006202 |
| conserved_site | Neurotransmitter-gated ion-channel, conserved site | 165 - 179 | IPR018000 |
| domain | Gamma-aminobutyric acid receptor subunit alpha 1-6, transmembrane domain | 251 - 438 | IPR047024 |
| domain | Gamma-aminobutyric acid receptor subunit alpha-1, extracellular domain | 55 - 248 | IPR047079 |
Functions
14 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| chloride channel complex | An ion channel complex through which chloride ions pass. |
| cytoplasmic vesicle membrane | The lipid bilayer surrounding a cytoplasmic vesicle. |
| dendrite membrane | The portion of the plasma membrane surrounding a dendrite. |
| GABA receptor complex | A protein complex which is capable of GABA receptor activity. Upon binding of gamma-aminobutyric acid (GABA) it transmits the signal from one side of the membrane to the other to initiate a change in cell activity. Major inhibitory receptor in vertebrate brain. Also found in other vertebrate tissues, invertebrates and possibly in plants. Effective benzodiazepine receptor. |
| GABA-A receptor complex | A protein complex which is capable of GABA-A receptor activity. In human, it is usually composed of either two alpha, two beta and one gamma chain of the GABA-A receptor subunits or 5 chains of the GABA-A receptor subunits rho1-3 (formally known as GABA-C receptor). |
| GABA-ergic synapse | A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of postsynaptic specialization membrane | The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynapse | The part of a synapse that is part of the post-synaptic cell. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
9 GO annotations of molecular function
| Name | Definition |
|---|---|
| diazepam binding | Binding to diazepam, one of the most widely used benzodiazepine drugs. It is used as an anti-anxiety-hypnotic agent and has the proprietary name Valium. |
| excitatory extracellular ligand-gated ion channel activity | Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential. |
| GABA receptor activity | Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms. |
| GABA-A receptor activity | Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels. |
| GABA-gated chloride ion channel activity | Enables the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts. |
| inhibitory extracellular ligand-gated ion channel activity | Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels. |
| neurotransmitter receptor activity | Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. |
| organic cyclic compound binding | Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure. |
| transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to histamine | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. |
| chemical synaptic transmission | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
| chloride transmembrane transport | The process in which chloride is transported across a membrane. |
| gamma-aminobutyric acid signaling pathway | The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to its receptor on the surface of a target cell. |
| inhibitory synapse assembly | The aggregation, arrangement and bonding together of a set of components to form an inhibitory synapse. |
| ion transmembrane transport | A process in which an ion is transported across a membrane. |
| nervous system process | A organ system process carried out by any of the organs or tissues of neurological system. |
| regulation of membrane potential | Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. |
| regulation of postsynaptic membrane potential | Any process that modulates the potential difference across a post-synaptic membrane. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| synaptic transmission, GABAergic | The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P08219 | GABRA1 | Gamma-aminobutyric acid receptor subunit alpha-1 | Bos taurus (Bovine) | PR |
| P19150 | GABRA1 | Gamma-aminobutyric acid receptor subunit alpha-1 | Gallus gallus (Chicken) | PR |
| P14867 | GABRA1 | Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (Human) | PR |
| Q91XP5 | Glra3 | Glycine receptor subunit alpha-3 | Mus musculus (Mouse) | PR |
| P48168 | Glrb | Glycine receptor subunit beta | Mus musculus (Mouse) | PR |
| P22933 | Gabrd | Gamma-aminobutyric acid receptor subunit delta | Mus musculus (Mouse) | PR |
| P22723 | Gabrg2 | Gamma-aminobutyric acid receptor subunit gamma-2 | Mus musculus (Mouse) | PR |
| P23979 | Htr3a | 5-hydroxytryptamine receptor 3A | Mus musculus (Mouse) | PR |
| P09690 | Chrnb1 | Acetylcholine receptor subunit beta | Mus musculus (Mouse) | PR |
| Q9R0W9 | Chrna6 | Neuronal acetylcholine receptor subunit alpha-6 | Mus musculus (Mouse) | PR |
| Q8BMN3 | Chrnb3 | Neuronal acetylcholine receptor subunit beta-3 | Mus musculus (Mouse) | PR |
| Q2MKA5 | Chrna5 | Neuronal acetylcholine receptor subunit alpha-5 | Mus musculus (Mouse) | PR |
| P04756 | Chrna1 | Acetylcholine receptor subunit alpha | Mus musculus (Mouse) | PR |
| Q64018 | Glra1 | Glycine receptor subunit alpha-1 | Mus musculus (Mouse) | PR |
| P62813 | Gabra1 | Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKKSRGLSDY | LWAWTLILST | LSGRSYGQPS | QDELKDNTTV | FTRILDRLLD | GYDNRLRPGL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GERVTEVKTD | IFVTSFGPVS | DHDMEYTIDV | FFRQSWKDER | LKFKGPMTVL | RLNNLMASKI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WTPDTFFHNG | KKSVAHNMTM | PNKLLRITED | GTLLYTMRLT | VRAECPMHLE | DFPMDAHACP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LKFGSYAYTR | AEVVYEWTRE | PARSVVVAED | GSRLNQYDLL | GQTVDSGIVQ | SSTGEYVVMT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| THFHLKRKIG | YFVIQTYLPC | IMTVILSQVS | FWLNRESVPA | RTVFGVTTVL | TMTTLSISAR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NSLPKVAYAT | AMDWFIAVCY | AFVFSALIEF | ATVNYFTKRG | YAWDGKSVVP | EKPKKVKDPL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IKKNNTYAPT | ATSYTPNLAR | GDPGLATIAK | SATIEPKEVK | PETKPPEPKK | TFNSVSKIDR |
| 430 | 440 | 450 | |||
| LSRIAFPLLF | GIFNLVYWAT | YLNREPQLKA | PTPHQ |