P30532
PR
Gene name |
CHRNA5 (NACHRA5) |
Protein name |
Neuronal acetylcholine receptor subunit alpha-5 |
Names |
|
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:1138 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P30532
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P30532-F1 | Predicted | AlphaFoldDB |
353 variants for P30532
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
VAR_046212 RCV000019049 CA127232 rs16969968 RCV000033213 RCV001787807 |
398 | D>N | Lung cancer susceptibility 2 Smoking as a quantitative trait locus 3 (sqtl3) Smoking as a quantitative trait locus 3 associated with susceptibility to lung cancer [ClinVar, Ensembl, UniProt] | Yes |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA393573033 rs1440785195 |
2 | A>T | No |
ClinGen TOPMed |
|
|
CA393573052 rs1200524514 |
5 | G>W | No |
ClinGen TOPMed |
|
|
rs943749647 CA273876658 |
6 | S>A | No |
ClinGen Ensembl |
|
|
CA273876664 rs997031085 |
6 | S>L | No |
ClinGen TOPMed gnomAD |
|
|
CA393573074 rs1212609168 |
9 | R>G | No |
ClinGen TOPMed |
|
|
rs952978648 CA273876674 |
9 | R>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1243536405 CA393573083 |
11 | L>F | No |
ClinGen TOPMed |
|
|
CA393573094 rs1176168726 |
12 | R>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1567047819 CA393573106 |
15 | L>F | No |
ClinGen Ensembl |
|
|
rs1412015317 CA393573114 |
16 | L>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1471930543 CA393573157 |
23 | R>C | No |
ClinGen TOPMed |
|
|
CA393573185 rs1393430909 |
27 | A>G | No |
ClinGen TOPMed gnomAD |
|
|
rs1393430909 CA393573184 |
27 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
rs982494622 CA393573199 |
30 | A>P | No |
ClinGen TOPMed gnomAD |
|
|
rs982494622 CA273876694 |
30 | A>S | No |
ClinGen TOPMed gnomAD |
|
|
CA393573200 rs1385607602 |
30 | A>V | No |
ClinGen gnomAD |
|
|
CA273876695 rs928078724 |
31 | G>D | No |
ClinGen TOPMed gnomAD |
|
|
CA393573231 rs1356799887 |
35 | R>T | No |
ClinGen TOPMed |
|
| TCGA novel | 38 | S>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs748585735 CA7683921 |
38 | S>P | No |
ClinGen ExAC gnomAD |
|
|
rs1185150285 CA393574832 |
39 | E>A | No |
ClinGen gnomAD |
|
|
rs772549498 CA7683923 |
40 | P>R | No |
ClinGen ExAC |
|
|
CA273885366 rs201999654 |
40 | P>T | No |
ClinGen TOPMed gnomAD |
|
|
CA7683924 rs368213023 |
42 | S>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA393574853 rs1472743717 |
43 | I>V | No |
ClinGen gnomAD |
|
|
CA393574878 rs1401463534 |
46 | H>R | No |
ClinGen gnomAD |
|
|
rs199919224 CA273885389 |
49 | S>N | No |
ClinGen Ensembl |
|
|
CA393574910 rs1449551218 |
50 | L>F | No |
ClinGen gnomAD |
|
|
CA393574913 rs1395837475 |
51 | L>F | No |
ClinGen Ensembl |
|
|
CA7683926 rs745545261 |
55 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA7683927 rs201040941 |
56 | Q>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA393574951 rs201040941 |
56 | Q>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1314195232 CA393574955 |
57 | D>H | No |
ClinGen gnomAD |
|
|
rs202110255 CA273885408 |
57 | D>V | No |
ClinGen Ensembl |
|
|
CA7683929 rs79835149 |
58 | Y>* | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs200129149 CA273885412 |
58 | Y>H | No |
ClinGen Ensembl |
|
|
CA7683930 rs543210727 |
59 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs1258701597 CA393575033 |
62 | V>I | No |
ClinGen gnomAD |
|
|
CA7683931 rs183719313 |
63 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs202057419 CA7683932 |
63 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA393575068 rs1300034813 |
64 | P>L | No |
ClinGen TOPMed |
|
|
CA7683936 rs760981472 |
67 | H>Q | No |
ClinGen ExAC gnomAD |
|
|
rs201556084 CA7683934 |
67 | H>R | No |
ClinGen ExAC gnomAD |
|
|
rs372781673 CA7683933 |
67 | H>Y | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1311124863 CA393575120 |
68 | L>M | No |
ClinGen gnomAD |
|
|
CA7683937 rs754032640 |
68 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs377184396 CA7683940 |
70 | D>E | No |
ClinGen ESP ExAC TOPMed |
|
|
CA393575149 rs1420220444 |
70 | D>N | No |
ClinGen TOPMed |
|
|
rs145146999 CA7683941 |
72 | I>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 74 | I>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs778220199 CA7683943 |
76 | F>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs56351164 CA7683942 |
76 | F>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs778220199 CA273885477 |
76 | F>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7683944 rs201569403 |
79 | A>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA273885515 rs201569403 |
79 | A>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749900040 CA273885502 |
79 | A>T | No |
ClinGen gnomAD |
|
|
CA7683945 rs201569403 |
79 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7683946 rs199587175 |
80 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7683948 rs768348027 |
81 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs771858151 CA7683951 |
83 | L>F | No |
ClinGen ExAC TOPMed |
|
|
rs533238214 CA273885548 |
83 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA7683952 rs773093762 |
84 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393575472 rs1344573389 |
86 | V>A | No |
ClinGen TOPMed |
|
|
rs760430286 CA7683954 |
86 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
TCGA novel rs1286786146 CA393575651 |
90 | N>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen gnomAD NCI-TCGA |
|
CA273893070 rs199649840 |
93 | M>K | No |
ClinGen Ensembl |
|
|
CA7683967 rs757754067 |
94 | T>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA273893081 rs200691818 |
95 | T>R | No |
ClinGen Ensembl |
|
|
CA7683969 rs148722844 COSM965386 |
97 | V>I | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA273893082 rs555893661 |
98 | W>* | No |
ClinGen 1000Genomes gnomAD |
|
|
rs1014744827 CA273893083 |
101 | Q>* | No |
ClinGen Ensembl |
|
|
CA393575725 rs768366429 |
101 | Q>L | No |
ClinGen ExAC gnomAD |
|
|
CA7683970 rs768366429 |
101 | Q>R | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 103 | W>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA393575762 rs1182689078 COSM70182 |
103 | W>C | ovary Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
rs201778201 CA273894149 |
105 | D>A | No |
ClinGen Ensembl |
|
|
CA393575778 rs1157428538 |
105 | D>Y | No |
ClinGen gnomAD |
|
|
rs1406983247 CA393575796 |
106 | V>A | No |
ClinGen gnomAD |
|
|
CA393575839 rs1393443224 CA393575841 |
110 | W>R | No |
ClinGen TOPMed gnomAD |
|
|
CA393575889 rs371640436 |
113 | D>E | No |
ClinGen TOPMed |
|
|
rs947116397 CA273894151 |
113 | D>H | No |
ClinGen gnomAD |
|
|
rs947116397 CA393575879 |
113 | D>N | No |
ClinGen gnomAD |
|
|
CA7683987 rs56023835 |
114 | D>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7683988 rs376394314 |
115 | Y>C | No |
ClinGen ESP ExAC gnomAD |
|
|
rs754710874 CA7683989 |
117 | G>E | No |
ClinGen ExAC gnomAD |
|
|
rs1278994313 CA393575953 |
121 | I>T | No |
ClinGen gnomAD |
|
|
rs74913206 CA273894174 |
122 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
rs143659162 CA7683991 |
122 | R>H | No |
ClinGen ESP ExAC gnomAD |
|
|
CA273894180 rs892335479 |
124 | P>L | No |
ClinGen TOPMed |
|
|
rs777337280 CA7683995 |
128 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA7683996 rs552142003 |
130 | T>A | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA273894192 rs902937153 |
131 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1180691964 CA393576083 |
132 | D>E | No |
ClinGen TOPMed gnomAD |
|
|
CA393576101 rs2229961 |
134 | V>F | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
VAR_046211 rs2229961 CA7683998 |
134 | V>I | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1300630412 CA393576121 |
136 | F>S | No |
ClinGen TOPMed |
|
|
CA393576496 rs1256222956 |
139 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
CA273895081 rs765553764 |
142 | R>C | No |
ClinGen Ensembl |
|
|
CA273895086 rs200320233 |
142 | R>H | No |
ClinGen TOPMed |
|
|
CA393576552 rs1363250762 |
143 | F>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs375192419 CA7684014 |
144 | E>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1321014916 CA393576579 |
146 | T>S | No |
ClinGen gnomAD |
|
|
rs1371109938 CA393576581 |
147 | S>G | No |
ClinGen gnomAD |
|
|
rs201563436 CA7684015 |
148 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs781155351 CA7684017 |
150 | T>A | No |
ClinGen ExAC gnomAD |
|
|
rs199550371 CA273895106 |
150 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
CA393576604 rs199550371 |
150 | T>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1374967801 CA393576605 |
151 | V>I | No |
ClinGen gnomAD |
|
| TCGA novel | 152 | I>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7684021 rs749486168 |
152 | I>L | No |
ClinGen ExAC gnomAD |
|
|
CA273895149 rs949729557 |
154 | Y>N | No |
ClinGen TOPMed |
|
|
CA393576650 rs1237581945 |
157 | T>I | No |
ClinGen TOPMed |
|
|
CA7684024 rs774605972 |
157 | T>P | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 158 | V>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7684025 rs762012646 |
161 | T>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs55863434 CA7684026 |
163 | P>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 163 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7684028 rs200503890 |
166 | Y>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
RCV000957328 CA7684029 rs80087508 |
167 | K>R | No |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1446367616 CA393576719 |
168 | S>N | No |
ClinGen gnomAD |
|
|
rs1259657704 CA393576716 |
168 | S>R | No |
ClinGen gnomAD |
|
|
CA7684030 rs754212902 |
168 | S>R | No |
ClinGen ExAC gnomAD |
|
|
rs763840987 CA7684032 |
170 | C>F | No |
ClinGen ExAC gnomAD |
|
|
rs751166834 CA7684033 |
171 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA7684034 rs370096844 |
171 | T>I | No |
ClinGen ESP ExAC gnomAD |
|
|
CA393576760 rs1567062384 |
174 | V>A | No |
ClinGen Ensembl |
|
|
rs780615731 CA7684035 |
175 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393576771 rs1567062410 |
176 | F>C | No |
ClinGen Ensembl |
|
|
CA273895290 rs71528534 |
176 | F>L | No |
ClinGen Ensembl |
|
|
CA273895292 COSM108281 rs151059425 |
178 | P>L | skin [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
rs1383366253 CA393576799 CA393576800 |
180 | D>E | No |
ClinGen TOPMed gnomAD |
|
|
CA273895293 rs151206721 |
180 | D>N | No |
ClinGen ESP |
|
| TCGA novel | 182 | Q>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA393576811 rs1379297504 |
182 | Q>R | No |
ClinGen TOPMed |
|
|
CA393576822 rs1382179893 |
183 | N>K | No |
ClinGen TOPMed gnomAD |
|
|
CA7684037 rs756066200 |
185 | S>Y | No |
ClinGen ExAC gnomAD |
|
|
CA7684038 rs779762437 |
186 | M>V | No |
ClinGen ExAC gnomAD |
|
|
CA273895304 rs1023953308 |
187 | K>I | No |
ClinGen Ensembl |
|
|
CA273895305 rs969761488 |
190 | S>P | No |
ClinGen Ensembl |
|
| TCGA novel | 195 | G>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7684041 COSM1708432 rs779298057 |
196 | S>L | skin [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs768293774 CA7684040 |
196 | S>T | No |
ClinGen ExAC gnomAD |
|
|
rs201173989 CA273895332 |
199 | D>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs201173989 CA7684043 |
199 | D>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs201956843 CA273895348 |
200 | I>T | No |
ClinGen Ensembl |
|
|
rs201487053 CA7684044 |
200 | I>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs761139232 CA7684045 |
203 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393576963 rs1252536259 |
205 | Q>K | No |
ClinGen gnomAD |
|
|
CA273895355 rs75583038 |
209 | K>* | No |
ClinGen ESP TOPMed |
|
|
rs1452385651 CA393577002 |
210 | R>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs776966489 CA7684048 |
211 | D>H | No |
ClinGen ExAC gnomAD |
|
|
CA7684049 rs759969645 |
213 | F>S | No |
ClinGen ExAC |
|
| rs1202847637 | 214 | D>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs765530585 CA7684050 |
214 | D>A | No |
ClinGen ExAC gnomAD |
|
|
rs1483907535 CA393577037 |
215 | N>D | No |
ClinGen TOPMed |
|
|
CA7684052 rs761452231 |
216 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA273895391 rs1016759554 |
217 | E>K | No |
ClinGen Ensembl |
|
|
rs1223380364 CA393577070 |
219 | E>A | No |
ClinGen TOPMed |
|
|
rs201346280 CA273895440 |
220 | I>M | No |
ClinGen Ensembl |
|
|
rs1567062553 CA393577081 |
221 | V>E | No |
ClinGen Ensembl |
|
|
CA393577080 rs201803037 CA273895448 |
221 | V>L | No |
ClinGen gnomAD |
|
|
rs749927555 CA7684056 |
222 | S>N | No |
ClinGen ExAC gnomAD |
|
|
CA7684057 rs200252306 |
223 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393577103 rs1219531112 |
225 | G>R | No |
ClinGen TOPMed |
|
| TCGA novel | 226 | S>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1334705709 CA393577133 |
229 | N>T | No |
ClinGen TOPMed gnomAD |
|
|
rs753668181 CA7684059 COSM1740209 |
232 | D>N | haematopoietic_and_lymphoid_tissue [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs531823205 CA7684061 |
234 | C>* | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA7684060 rs754813352 |
234 | C>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1258493260 CA393577176 |
235 | C>S | No |
ClinGen gnomAD |
|
|
rs772406108 CA7684064 |
236 | W>* | No |
ClinGen ExAC gnomAD |
|
|
rs778043206 CA7684065 |
236 | W>C | No |
ClinGen ExAC gnomAD |
|
|
rs61742337 CA7684067 |
238 | P>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA393577198 rs61742337 |
238 | P>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs747148242 CA7684066 |
238 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393577218 rs1372147833 |
241 | T>I | No |
ClinGen TOPMed |
|
|
CA7684068 CA273895522 rs201492819 |
242 | Y>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393577230 rs1425060068 |
243 | S>L | No |
ClinGen TOPMed |
|
|
rs1164607160 CA393577243 |
245 | V>A | No |
ClinGen gnomAD |
|
|
rs150377720 CA7684069 |
246 | I>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1044168331 CA273895526 |
246 | I>V | No |
ClinGen Ensembl |
|
|
rs770212312 CA7684070 |
248 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA7684071 COSM1201124 rs775819304 |
248 | R>H | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA273895533 rs775819304 |
248 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs137878726 CA7684072 |
249 | L>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs767124667 CA7684073 |
251 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs372825597 CA7684074 |
252 | F>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7684075 rs200232683 |
253 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200232683 CA273895559 |
253 | Y>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7684076 rs374468403 |
254 | T>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA273895568 rs951884922 |
255 | L>F | No |
ClinGen TOPMed |
|
|
CA273895580 rs983271367 |
260 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs1309089415 CA393577333 |
261 | C>R | No |
ClinGen gnomAD |
|
|
CA393577336 rs1314435912 |
261 | C>Y | No |
ClinGen TOPMed |
|
|
rs201483179 CA7684079 |
262 | I>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201483179 CA7684080 |
262 | I>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7684078 rs754958913 |
262 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1480433749 CA393577346 |
263 | G>R | No |
ClinGen gnomAD |
|
|
rs868352551 CA273895620 |
265 | S>L | No |
ClinGen Ensembl |
|
|
CA7684082 rs138719535 |
266 | F>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7684084 rs142772554 |
270 | L>F | No |
ClinGen ESP ExAC gnomAD |
|
|
rs926986572 CA273895649 |
273 | Y>C | No |
ClinGen TOPMed |
|
|
CA393577414 rs1272590618 |
274 | L>I | No |
ClinGen gnomAD |
|
|
CA393577417 rs1596064105 |
274 | L>R | No |
ClinGen Ensembl |
|
|
CA273895652 rs936995586 |
275 | P>S | No |
ClinGen TOPMed |
|
|
CA7684087 rs781129738 |
276 | S>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7684088 rs371342198 |
278 | E>A | No |
ClinGen ESP ExAC gnomAD |
|
|
CA7684089 rs770263622 |
280 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA7684090 rs565053075 |
282 | I>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1567062751 CA393577477 |
283 | C>S | No |
ClinGen Ensembl |
|
|
CA7684091 rs749683576 |
285 | C>R | No |
ClinGen ExAC gnomAD |
|
|
rs1017054259 CA273895733 |
287 | S>L | No |
ClinGen TOPMed gnomAD |
|
|
rs147498556 CA7684093 |
288 | V>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs148560500 CA273895749 |
289 | L>R | No |
ClinGen ESP TOPMed |
|
|
CA7684094 rs760176741 |
289 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA7684097 rs775987827 |
290 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA393577527 rs1487143659 |
292 | L>S | No |
ClinGen gnomAD |
|
|
rs200972466 CA273895759 |
293 | T>S | No |
ClinGen Ensembl |
|
|
rs765300879 CA7684100 |
295 | F>Y | No |
ClinGen ExAC gnomAD |
|
|
CA7684104 rs200010345 |
299 | I>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA273895783 rs79518498 |
300 | E>* | No |
ClinGen Ensembl |
|
|
rs757408983 CA7684105 |
300 | E>D | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 301 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs150696868 CA273895786 |
302 | I>L | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs867154905 CA273895791 |
302 | I>N | No |
ClinGen gnomAD |
|
|
CA7684107 rs745918259 |
305 | S>* | No |
ClinGen ExAC gnomAD |
|
|
rs1305978943 CA393577625 |
308 | K>R | No |
ClinGen gnomAD |
|
|
CA273895823 rs944978839 |
311 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
rs201569673 CA273895824 |
313 | I>V | No |
ClinGen Ensembl |
|
| TCGA novel | 315 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA273895825 rs868388135 |
316 | Y>C | No |
ClinGen Ensembl |
|
|
CA7684108 rs116099178 |
317 | L>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 318 | V>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7684110 rs74865777 |
321 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200102110 CA273895831 |
324 | V>L | No |
ClinGen Ensembl |
|
| TCGA novel | 327 | S>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA393577802 rs1250686051 |
328 | I>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA7684111 rs769011950 |
329 | M>V | No |
ClinGen ExAC gnomAD |
|
|
CA273895833 rs200946954 |
330 | V>I | No |
ClinGen Ensembl |
|
|
rs867013198 CA273895835 |
331 | T>I | No |
ClinGen Ensembl |
|
|
CA7684113 rs201259246 |
332 | V>I | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA7684115 rs776310455 |
334 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA7684116 rs759142711 |
334 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7684117 rs139612394 |
335 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7684118 rs775575449 |
337 | I>F | No |
ClinGen ExAC gnomAD |
|
|
rs1436063972 CA393577931 |
338 | H>D | No |
ClinGen gnomAD |
|
|
rs1280180578 CA393577957 |
340 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs762980943 CA7684120 |
340 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs202070829 CA273895886 |
343 | S>A | No |
ClinGen Ensembl |
|
|
CA393578020 rs1567062983 |
345 | H>R | No |
ClinGen Ensembl |
|
|
CA273895887 rs964002776 |
346 | N>D | No |
ClinGen Ensembl |
|
|
rs558752984 CA7684123 COSM965393 |
349 | A>V | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD |
|
CA7684124 rs767663657 |
350 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1277622813 CA393578101 |
352 | V>F | No |
ClinGen TOPMed |
|
|
CA7684125 rs570647862 |
353 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA7684126 rs201385812 |
353 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA393578139 rs1400701147 |
355 | I>M | No |
ClinGen TOPMed |
|
|
CA7684128 rs201995384 |
355 | I>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs780040957 CA7684127 |
355 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200449882 CA273895927 |
356 | F>L | No |
ClinGen Ensembl |
|
|
CA393578164 rs1476159331 |
358 | H>Y | No |
ClinGen gnomAD |
|
|
rs79721430 CA7684130 |
359 | T>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA393578190 rs1567063057 |
360 | L>F | No |
ClinGen Ensembl |
|
|
CA393578201 rs1480979773 |
361 | P>S | No |
ClinGen TOPMed |
|
|
CA393578209 rs1404966453 |
362 | K>Q | No |
ClinGen gnomAD |
|
|
rs79109919 CA7684132 RCV000887009 |
363 | L>Q | No |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA393578273 rs1596064293 |
367 | R>G | No |
ClinGen Ensembl |
|
|
CA393578296 rs1356352493 |
368 | S>N | No |
ClinGen gnomAD |
|
|
CA7684133 rs772437201 |
371 | D>H | No |
ClinGen ExAC gnomAD |
|
|
rs1235714060 CA393578357 |
373 | Y>H | No |
ClinGen gnomAD |
|
|
rs1242573862 CA393578378 |
374 | F>C | No |
ClinGen TOPMed |
|
|
rs745450184 CA7684135 |
374 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA393578387 rs1356157688 |
375 | T>A | No |
ClinGen gnomAD |
|
|
CA7684137 rs769498175 |
376 | Q>L | No |
ClinGen ExAC gnomAD |
|
|
CA7684138 rs769498175 |
376 | Q>P | No |
ClinGen ExAC gnomAD |
|
|
CA273896016 rs201916656 |
380 | T>A | No |
ClinGen Ensembl |
|
|
rs201916656 CA393578448 |
380 | T>S | No |
ClinGen Ensembl |
|
|
rs763035811 CA7684139 |
381 | E>A | No |
ClinGen ExAC gnomAD |
|
|
CA393578490 rs1257638091 |
383 | G>C | No |
ClinGen gnomAD |
|
|
rs1185778769 CA393578514 |
385 | G>R | No |
ClinGen gnomAD |
|
|
CA393578608 rs1408455371 |
392 | T>I | No |
ClinGen gnomAD |
|
|
CA273896069 rs977099173 |
393 | L>V | No |
ClinGen TOPMed |
|
|
rs1376188067 CA393578624 |
394 | E>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs143586773 CA7684148 |
396 | A>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs143586773 CA7684147 |
396 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA273896078 rs768325287 |
399 | S>A | No |
ClinGen Ensembl |
|
|
CA7684151 rs778281973 |
399 | S>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393578693 rs778281973 |
399 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7684152 rs201775979 |
400 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7684153 rs76766434 |
401 | R>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
COSM167539 CA7684154 rs141180754 |
401 | R>H | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA273896104 rs76766434 |
401 | R>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA273896108 rs1018181118 |
402 | Y>H | No |
ClinGen Ensembl |
|
|
rs1185773169 CA393578764 |
405 | R>S | No |
ClinGen TOPMed |
|
|
CA393578784 rs1356885864 |
407 | I>T | No |
ClinGen gnomAD |
|
|
CA393578802 rs1205594105 |
408 | M>I | No |
ClinGen TOPMed |
|
|
rs202178144 CA7684158 |
412 | D>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7684159 rs200127699 |
414 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs771827809 CA7684160 |
414 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393579145 rs1310445815 |
416 | V>A | No |
ClinGen gnomAD |
|
|
CA7684176 rs748912077 |
417 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs778479885 CA393579172 |
419 | D>E | No |
ClinGen ExAC gnomAD |
|
|
CA7684177 rs754450688 |
419 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs1327013276 CA393579180 |
420 | W>C | No |
ClinGen gnomAD |
|
|
CA273897937 rs934230114 |
421 | K>Q | No |
ClinGen TOPMed |
|
|
rs1372664585 CA393579201 |
423 | I>V | No |
ClinGen gnomAD |
|
|
CA273897942 rs202052590 |
425 | Q>R | No |
ClinGen TOPMed gnomAD |
|
|
rs150329151 CA7684179 |
426 | V>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs150329151 CA7684180 |
426 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7684182 rs368612437 |
429 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7684181 rs138253116 |
429 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs770658199 CA7684183 |
430 | M>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393579257 rs1482714291 |
430 | M>L | No |
ClinGen TOPMed |
|
|
rs776726741 CA7684184 |
433 | W>G | No |
ClinGen ExAC gnomAD |
|
|
rs1038461611 CA273897978 |
434 | T>A | No |
ClinGen TOPMed |
|
|
CA7684186 rs759802002 |
435 | F>C | No |
ClinGen ExAC gnomAD |
|
|
CA393579301 rs1266274639 COSM1135727 |
435 | F>L | kidney [Cosmic] | No |
ClinGen cosmic curated TOPMed |
|
CA7684188 rs144352852 COSM1135727 |
435 | F>L | kidney [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
CA7684189 rs202066018 |
436 | L>R | No |
ClinGen ESP |
|
|
rs202136309 CA7684193 |
437 | F>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs763412847 CA7684191 |
437 | F>S | No |
ClinGen ExAC gnomAD |
|
|
CA7684194 rs367546696 |
438 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA273898036 rs367546696 |
438 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs200357731 CA7684195 |
440 | I>F | No |
ClinGen ExAC gnomAD |
|
|
CA7684197 rs754643899 |
440 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs200357731 CA7684196 |
440 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs77773727 CA273898080 |
442 | G>E | No |
ClinGen Ensembl |
|
|
rs148376112 CA273898079 |
442 | G>R | No |
ClinGen ESP TOPMed |
|
|
rs200384194 CA273898086 |
443 | S>Y | No |
ClinGen gnomAD |
|
| TCGA novel | 444 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs532896027 CA7684199 |
446 | L>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs757859948 CA7684200 |
448 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs1456048111 CA393579508 |
450 | V>A | No |
ClinGen gnomAD |
|
|
CA7684202 rs777707103 |
451 | I>M | No |
ClinGen ExAC gnomAD |
|
|
CA273898113 rs959165006 |
451 | I>T | No |
ClinGen Ensembl |
|
|
CA7684203 rs746886634 |
453 | K>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393579584 rs1159678265 |
455 | A>E | No |
ClinGen TOPMed |
|
|
rs1231126574 CA393579613 |
457 | I>T | No |
ClinGen TOPMed |
|
|
CA393579605 rs1378759354 |
457 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
rs770782949 CA393579643 |
460 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7684204 rs770782949 |
460 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 461 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs76071148 CA7684205 |
462 | H>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA393579688 rs1318987637 |
463 | I>M | No |
ClinGen gnomAD |
|
|
rs746129356 CA7684206 |
463 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA273898171 rs751038368 |
464 | G>E | No |
ClinGen TOPMed |
|
|
CA7684208 rs770027654 |
466 | A>E | No |
ClinGen ExAC TOPMed |
|
|
CA273898178 rs200454752 |
467 | N>S | No |
ClinGen gnomAD |
|
|
CA393579726 rs200454752 |
467 | N>T | No |
ClinGen gnomAD |
|
|
rs1332485553 CA393579746 |
468 | K>N | No |
ClinGen gnomAD |
|
|
CA393579759 rs1481090382 |
469 | K>C | No |
ClinGen gnomAD |
|
|
rs775537854 CA7684209 |
469 | K>R | No |
ClinGen ExAC gnomAD |
No associated diseases with P30532
4 regional properties for P30532
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Neurotransmitter-gated ion-channel transmembrane domain | 257 - 369 | IPR006029-1 |
| domain | Neurotransmitter-gated ion-channel transmembrane domain | 382 - 447 | IPR006029-2 |
| domain | Neurotransmitter-gated ion-channel ligand-binding domain | 48 - 249 | IPR006202 |
| conserved_site | Neurotransmitter-gated ion-channel, conserved site | 170 - 184 | IPR018000 |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| acetylcholine-gated channel complex | A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding. |
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| dopaminergic synapse | A synapse that uses dopamine as a neurotransmitter. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic membrane | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| acetylcholine receptor activity | Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| acetylcholine-gated cation-selective channel activity | Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine. |
| excitatory extracellular ligand-gated ion channel activity | Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential. |
| ligand-gated ion channel activity | Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. |
| neurotransmitter receptor activity | Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. |
| transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| behavioral response to nicotine | Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus. |
| chemical synaptic transmission | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
| ion transmembrane transport | A process in which an ion is transported across a membrane. |
| membrane depolarization | The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential. |
| nervous system process | A organ system process carried out by any of the organs or tissues of neurological system. |
| regulation of membrane potential | Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. |
| regulation of synaptic vesicle exocytosis | Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis. |
| response to nicotine | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| synaptic transmission, cholinergic | The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
37 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q07263 | CHRNA3 | Neuronal acetylcholine receptor subunit alpha-3 | Bos taurus (Bovine) | PR |
| P04758 | CHRNB1 | Acetylcholine receptor subunit beta | Bos taurus (Bovine) | PR |
| Q8SPU7 | CHRNA5 | Neuronal acetylcholine receptor subunit alpha-5 | Bos taurus (Bovine) | PR |
| P09481 | CHRNA3 | Neuronal acetylcholine receptor subunit alpha-3 | Gallus gallus (Chicken) | PR |
| Q9I8C7 | CHRNA10 | Neuronal acetylcholine receptor subunit alpha-10 | Gallus gallus (Chicken) | PR |
| P43679 | CHRNB3 | Neuronal acetylcholine receptor subunit beta-3 | Gallus gallus (Chicken) | PR |
| P26152 | CHRNA5 | Neuronal acetylcholine receptor subunit alpha-5 | Gallus gallus (Chicken) | PR |
| Q5IS76 | CHRNA6 | Neuronal acetylcholine receptor subunit alpha-6 | Pan troglodytes (Chimpanzee) | PR |
| Q5IS75 | CHRNB3 | Neuronal acetylcholine receptor subunit beta-3 | Pan troglodytes (Chimpanzee) | PR |
| P25162 | nAChRbeta2 | Acetylcholine receptor subunit beta-like 2 | Drosophila melanogaster (Fruit fly) | PR |
| Q05901 | CHRNB3 | Neuronal acetylcholine receptor subunit beta-3 | Homo sapiens (Human) | PR |
| P14867 | GABRA1 | Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (Human) | PR |
| O14764 | GABRD | Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (Human) | PR |
| Q9UN88 | GABRQ | Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (Human) | PR |
| P11230 | CHRNB1 | Acetylcholine receptor subunit beta | Homo sapiens (Human) | PR |
| Q15825 | CHRNA6 | Neuronal acetylcholine receptor subunit alpha-6 | Homo sapiens (Human) | PR |
| P32297 | CHRNA3 | Neuronal acetylcholine receptor subunit alpha-3 | Homo sapiens (Human) | PR |
| P48167 | GLRB | Glycine receptor subunit beta | Homo sapiens (Human) | PR |
| P23415 | GLRA1 | Glycine receptor subunit alpha-1 | Homo sapiens (Human) | PR |
| O75311 | GLRA3 | Glycine receptor subunit alpha-3 | Homo sapiens (Human) | PR |
| P23979 | Htr3a | 5-hydroxytryptamine receptor 3A | Mus musculus (Mouse) | PR |
| P04756 | Chrna1 | Acetylcholine receptor subunit alpha | Mus musculus (Mouse) | PR |
| Q9R0W9 | Chrna6 | Neuronal acetylcholine receptor subunit alpha-6 | Mus musculus (Mouse) | PR |
| P09690 | Chrnb1 | Acetylcholine receptor subunit beta | Mus musculus (Mouse) | PR |
| Q8BMN3 | Chrnb3 | Neuronal acetylcholine receptor subunit beta-3 | Mus musculus (Mouse) | PR |
| Q2MKA5 | Chrna5 | Neuronal acetylcholine receptor subunit alpha-5 | Mus musculus (Mouse) | PR |
| P43144 | Chrna9 | Neuronal acetylcholine receptor subunit alpha-9 | Rattus norvegicus (Rat) | PR |
| P35563 | Htr3a | 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Rat) | PR |
| P43143 | Chrna6 | Neuronal acetylcholine receptor subunit alpha-6 | Rattus norvegicus (Rat) | PR |
| P12391 | Chrnb3 | Neuronal acetylcholine receptor subunit beta-3 | Rattus norvegicus (Rat) | PR |
| P04757 | Chrna3 | Neuronal acetylcholine receptor subunit alpha-3 | Rattus norvegicus (Rat) | PR |
| P25109 | Chrnb1 | Acetylcholine receptor subunit beta | Rattus norvegicus (Rat) | PR |
| P25108 | Chrna1 | Acetylcholine receptor subunit alpha | Rattus norvegicus (Rat) | PR |
| P20420 | Chrna5 | Neuronal acetylcholine receptor subunit alpha-5 | Rattus norvegicus (Rat) | PR |
| P54244 | deg-3 | Acetylcholine receptor subunit alpha-type deg-3 | Caenorhabditis elegans | PR |
| P54246 | acr-5 | Acetylcholine receptor subunit alpha-type acr-5 | Caenorhabditis elegans | PR |
| Q93149 | acr-3 | Acetylcholine receptor subunit beta-type acr-3 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAARGSGPRA | LRLLLLVQLV | AGRCGLAGAA | GGAQRGLSEP | SSIAKHEDSL | LKDLFQDYER |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WVRPVEHLND | KIKIKFGLAI | SQLVDVDEKN | QLMTTNVWLK | QEWIDVKLRW | NPDDYGGIKV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IRVPSDSVWT | PDIVLFDNAD | GRFEGTSTKT | VIRYNGTVTW | TPPANYKSSC | TIDVTFFPFD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LQNCSMKFGS | WTYDGSQVDI | ILEDQDVDKR | DFFDNGEWEI | VSATGSKGNR | TDSCCWYPYV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TYSFVIKRLP | LFYTLFLIIP | CIGLSFLTVL | VFYLPSNEGE | KICLCTSVLV | SLTVFLLVIE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EIIPSSSKVI | PLIGEYLVFT | MIFVTLSIMV | TVFAINIHHR | SSSTHNAMAP | LVRKIFLHTL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PKLLCMRSHV | DRYFTQKEET | ESGSGPKSSR | NTLEAALDSI | RYITRHIMKE | NDVREVVEDW |
| 430 | 440 | 450 | 460 | ||
| KFIAQVLDRM | FLWTFLFVSI | VGSLGLFVPV | IYKWANILIP | VHIGNANK |