Q2KJ29
Gene name |
PCGF3 |
Protein name |
Polycomb group RING finger protein 3 |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:615967 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2KJ29
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2KJ29-F1 | Predicted | AlphaFoldDB |
46 variants for Q2KJ29
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs440272355 | 16 | T>P | No | EVA | |
| rs467435340 | 37 | F>S | No | EVA | |
| rs437720450 | 38 | C>S | No | EVA | |
| rs449658980 | 40 | S>R | No | EVA | |
| rs464936855 | 42 | L>R | No | EVA | |
| rs453991966 | 43 | V>G | No | EVA | |
| rs472409135 | 44 | K>Q | No | EVA | |
| rs436188214 | 46 | L>R | No | EVA | |
| rs454598702 | 50 | N>K | No | EVA | |
| rs476464356 | 51 | T>P | No | EVA | |
| rs458940008 | 54 | T>P | No | EVA | |
| rs876017543 | 58 | V>A | No | EVA | |
| rs471018013 | 60 | H>P | No | EVA | |
| rs441479934 | 61 | Q>K | No | EVA | |
| rs460031637 | 62 | S>T | No | EVA | |
| rs876080909 | 63 | H>P | No | EVA | |
| rs434262513 | 64 | P>R | No | EVA | |
| rs448673580 | 66 | Q>* | No | EVA | |
| rs463960601 | 66 | Q>P | No | EVA | |
| rs449744216 | 67 | Y>D | No | EVA | |
| rs464963131 | 68 | I>S | No | EVA | |
| rs462367314 | 112 | T>S | No | EVA | |
| rs453744511 | 118 | H>P | No | EVA | |
| rs441401763 | 120 | D>A | No | EVA | |
| rs471232961 | 122 | H>P | No | EVA | |
| rs452728038 | 124 | N>T | No | EVA | |
| rs1118277989 | 131 | D>G | No | EVA | |
| rs458340016 | 155 | V>G | No | EVA | |
| rs480181792 | 156 | S>G | No | EVA | |
| rs480181792 | 156 | S>R | No | EVA | |
| rs446980048 | 163 | S>R | No | EVA | |
| rs480910684 | 170 | K>Q | No | EVA | |
| rs448050082 | 173 | W>G | No | EVA | |
| rs469899753 | 173 | W>S | No | EVA | |
| rs436746817 | 174 | I>S | No | EVA | |
| rs452115461 | 175 | R>L | No | EVA | |
| rs464405293 | 188 | F>V | No | EVA | |
| rs434720910 | 190 | A>G | No | EVA | |
| rs453119010 | 191 | K>N | No | EVA | |
| rs449667912 | 228 | K>E | No | EVA | |
| rs431943321 | 229 | A>G | No | EVA | |
| rs466020122 | 230 | P>A | No | EVA | |
| rs454750927 | 231 | L>P | No | EVA | |
| rs437011497 | 234 | H>P | No | EVA | |
| rs437011497 | 234 | H>R | No | EVA | |
| rs452593041 | 236 | R>I | No | EVA |
No associated diseases with Q2KJ29
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| PcG protein complex | A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure. |
| PRC1 complex | A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling. |
| X chromosome | The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| histone H2A-K119 monoubiquitination | The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms. |
| inactivation of X chromosome by genomic imprinting | Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by genomic imprinting. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2KJ29 | PCGF3 | Polycomb group RING finger protein 3 | Bos taurus (Bovine) | PR |
| A0JN86 | PCGF5 | Polycomb group RING finger protein 5 | Bos taurus (Bovine) | PR |
| Q9BYE7 | PCGF6 | Polycomb group RING finger protein 6 | Homo sapiens (Human) | PR |
| Q86SE9 | PCGF5 | Polycomb group RING finger protein 5 | Homo sapiens (Human) | PR |
| Q3KNV8 | PCGF3 | Polycomb group RING finger protein 3 | Homo sapiens (Human) | PR |
| Q3UK78 | Pcgf5 | Polycomb group RING finger protein 5 | Mus musculus (Mouse) | PR |
| Q8BTQ0 | PcgF3 | Polycomb group RING finger protein 3 | Mus musculus (Mouse) | PR |
| Q07G17 | pcgf3 | Polycomb group RING finger protein 3 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q1JPS1 | pcgf5b | Polycomb group RING finger protein 5-B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| B3DK16 | pcgf5a | Polycomb group RING finger protein 5-A | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLTRKIKLWD | INAHITCRLC | SGYLIDATTV | TECLHTFCRS | CLVKYLEENN | TCPTCRIVIH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QSHPLQYIGH | DRTMQDIVYK | LVPGLQEAEM | RKQREFYHKL | GLEVPGDIKG | ETCSAKQHLD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PHRNGETKAD | DSSNKEAAEE | KQEEDGDYHR | SDEQVSICLE | CNSSKLRGLK | RKWIRCSAQA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TVLHLKKFIA | KKLNLSSFNE | LDILCNEEIL | GKDHTLKFVV | VTRWRFKKAP | LLLHYRPKMD |
| LL |