Q3UK78
Gene name |
Pcgf5 (Rnf159) |
Protein name |
Polycomb group RING finger protein 5 |
Names |
RING finger protein 159 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:76073 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3UK78
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3UK78-F1 | Predicted | AlphaFoldDB |
4 variants for Q3UK78
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389540374 | 104 | Q>L | No | EVA | |
| rs3389528219 | 135 | S>R | No | EVA | |
| rs3389535271 | 141 | I>T | No | EVA | |
| rs3389548421 | 167 | C>F | No | EVA |
No associated diseases with Q3UK78
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| PcG protein complex | A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure. |
| PRC1 complex | A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| histone H2A-K119 monoubiquitination | The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms. |
| inactivation of X chromosome by genomic imprinting | Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by genomic imprinting. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2KJ29 | PCGF3 | Polycomb group RING finger protein 3 | Bos taurus (Bovine) | PR |
| A0JN86 | PCGF5 | Polycomb group RING finger protein 5 | Bos taurus (Bovine) | PR |
| Q3KNV8 | PCGF3 | Polycomb group RING finger protein 3 | Homo sapiens (Human) | PR |
| Q9BYE7 | PCGF6 | Polycomb group RING finger protein 6 | Homo sapiens (Human) | PR |
| Q86SE9 | PCGF5 | Polycomb group RING finger protein 5 | Homo sapiens (Human) | PR |
| Q8BTQ0 | PcgF3 | Polycomb group RING finger protein 3 | Mus musculus (Mouse) | PR |
| Q07G17 | pcgf3 | Polycomb group RING finger protein 3 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| B3DK16 | pcgf5a | Polycomb group RING finger protein 5-A | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q1JPS1 | pcgf5b | Polycomb group RING finger protein 5-B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATQRKHLVK | DFNPYITCYI | CKGYLIKPTT | VTECLHTFCK | TCIVQHFEDS | NDCPRCGNQV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HETNPLEMLR | LDNTLEEIIF | KLVPGLREQE | LQRELEFWKK | NKPQENGQDD | ISKVDKSKAD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EEGDENQDDK | DYHRSDPQIA | ICLDCLRNNG | QSGDNVVKGL | MKKFIRCSTR | VTVGTIKKFL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SLKLKLPSSY | ELDVLCNGEI | MGKDHTMEFI | YMTRWRLRGE | NLCCLNCSAS | QVCSQDGTLY |
| 250 | |||||
| QSYPMVLQYR | PRIDFG |