A0JN86

PR
Gene name
PCGF5
Protein name
Polycomb group RING finger protein 5
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:528946
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

57-186 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A0JN86

Entry ID Method Resolution Chain Position Source
AF-A0JN86-F1 Predicted AlphaFoldDB

43 variants for A0JN86

Variant ID(s) Position Change Description Diseaes Association Provenance
rs458211431 45 Q>R No EVA
rs473327061 48 E>V No EVA
rs434350278 90 L>F No EVA
rs452849689 90 L>R No EVA
rs474523783 91 E>A No EVA
rs442975721 91 E>D No EVA
rs455158379 92 R>L No EVA
rs443964810 93 E>* No EVA
rs470944916 93 E>D No EVA
rs459246324 93 E>G No EVA
rs441261089 94 S>A No EVA
rs459812549 94 S>F No EVA
rs441261089 94 S>P No EVA
rs481591712 95 E>* No EVA
rs448168857 95 E>D No EVA
rs481591712 95 E>K No EVA
rs463604582 96 F>I No EVA
rs445875386 97 W>* No EVA
rs445875386 97 W>C No EVA
rs482173174 97 W>L No EVA
rs456295864 100 N>K No EVA
rs446428026 101 K>N No EVA
rs435316698 103 Q>* No EVA
rs435316698 103 Q>K No EVA
rs437394121 104 E>A No EVA
rs476795013 104 E>K No EVA
rs452795936 105 N>K No EVA
rs441218138 107 Q>E No EVA
rs441218138 107 Q>K No EVA
rs469084168 124 E>A No EVA
rs477929050 150 Q>R No EVA
rs446250247 152 G>E No EVA
rs451097490 181 L>* No EVA
rs463061685 181 L>F No EVA
rs478343356 185 L>P No EVA
rs445186399 190 E>D No EVA
rs471387914 208 F>L No EVA
rs450171055 220 N>I No EVA
rs439417775 231 V>G No EVA
rs457889342 237 P>L No EVA
rs479431220 240 Q>R No EVA
rs480035353 245 V>G No EVA
rs440611126 252 I>M No EVA

No associated diseases with A0JN86

3 regional properties for A0JN86

Type Name Position InterPro Accession
domain Zinc finger, RING-type 18 - 56 IPR001841
conserved_site Zinc finger, RING-type, conserved site 34 - 43 IPR017907
domain RAWUL domain 162 - 215 IPR032443

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Nucleus, nucleoplasm
  • Recruited by the non-coding RNA Xist to specific nuclear foci that probably correspond to the inactivated X chromosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
PcG protein complex A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.
PRC1 complex A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling.
X chromosome The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males.

1 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.

4 GO annotations of biological process

Name Definition
histone H2A-K119 monoubiquitination The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms.
inactivation of X chromosome by genomic imprinting Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by genomic imprinting.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KJ29 PCGF3 Polycomb group RING finger protein 3 Bos taurus (Bovine) PR
Q3KNV8 PCGF3 Polycomb group RING finger protein 3 Homo sapiens (Human) PR
Q9BYE7 PCGF6 Polycomb group RING finger protein 6 Homo sapiens (Human) PR
Q86SE9 PCGF5 Polycomb group RING finger protein 5 Homo sapiens (Human) PR
Q8BTQ0 PcgF3 Polycomb group RING finger protein 3 Mus musculus (Mouse) PR
Q3UK78 Pcgf5 Polycomb group RING finger protein 5 Mus musculus (Mouse) PR
Q07G17 pcgf3 Polycomb group RING finger protein 3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
B3DK16 pcgf5a Polycomb group RING finger protein 5-A Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q1JPS1 pcgf5b Polycomb group RING finger protein 5-B Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MATQRKHLVK DFNPYITCYI CKGYLIKPTT VTECLHTFCK TCIVQHFEDS NDCPRCGNQV
70 80 90 100 110 120
HETNPLEMLR LDNTLEEIIF KLVPGLREQL ERESEFWKKN KPQENGQDDM SKVDKPKVDE
130 140 150 160 170 180
EGDENQDDKD YHRSDPQIAI CLDCLRNNGQ SGDNVVKGLM KKFIRCSTRV TVGTIKKFLS
190 200 210 220 230 240
LKLKLPSSYE LDVLCNGEIM GKDHTMEFIY MTRWRLRGEN FRCLNCSASQ VCSQDGPLYQ
250
SYPMVLQYRP RIDFG