Q1JPS1

PR
Gene name
pcgf5b (zgc:136815)
Protein name
Polycomb group RING finger protein 5-B
Names
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:692252
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

56-182 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1JPS1

Entry ID Method Resolution Chain Position Source
AF-Q1JPS1-F1 Predicted AlphaFoldDB

No variants for Q1JPS1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q1JPS1

No associated diseases with Q1JPS1

3 regional properties for Q1JPS1

Type Name Position InterPro Accession
domain Zinc finger, RING-type 18 - 56 IPR001841
conserved_site Zinc finger, RING-type, conserved site 34 - 43 IPR017907
domain RAWUL domain 159 - 226 IPR032443

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
PcG protein complex A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.
PRC1 complex A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling.

1 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
histone H2A-K119 monoubiquitination The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KJ29 PCGF3 Polycomb group RING finger protein 3 Bos taurus (Bovine) PR
A0JN86 PCGF5 Polycomb group RING finger protein 5 Bos taurus (Bovine) PR
Q3KNV8 PCGF3 Polycomb group RING finger protein 3 Homo sapiens (Human) PR
Q9BYE7 PCGF6 Polycomb group RING finger protein 6 Homo sapiens (Human) PR
Q86SE9 PCGF5 Polycomb group RING finger protein 5 Homo sapiens (Human) PR
Q8BTQ0 PcgF3 Polycomb group RING finger protein 3 Mus musculus (Mouse) PR
Q3UK78 Pcgf5 Polycomb group RING finger protein 5 Mus musculus (Mouse) PR
Q07G17 pcgf3 Polycomb group RING finger protein 3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
B3DK16 pcgf5a Polycomb group RING finger protein 5-A Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MTSHRKHLVR DFNHFITCFV CKGYLIKPTT VTECLHTFCK SCIVQHFEDS NDCPKCGIQV
70 80 90 100 110 120
HETNPLEMLR LDNTLEEVIF KLVPGLREKE QQQEDEFWRR KESNDENGPM CKKRRVDEED
130 140 150 160 170 180
DDKGDGDYHR SDPQIAICLD CLRINGQMGE NIVKGLMKKF IRCSTRVTVG TIKKFLSLKL
190 200 210 220 230
KLPSSYELDV LCNGEIMGKD HTMEFIYMTR WRLRGENVYP MVLEYRPRID FG