B3DK16
Gene name |
pcgf5a |
Protein name |
Polycomb group RING finger protein 5-A |
Names |
|
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:562327 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B3DK16
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B3DK16-F1 | Predicted | AlphaFoldDB |
No variants for B3DK16
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B3DK16 | |||||
No associated diseases with B3DK16
1 regional properties for B3DK16
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phosducin, thioredoxin-like domain | 27 - 181 | IPR024253 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| PcG protein complex | A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure. |
| PRC1 complex | A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| histone H2A-K119 monoubiquitination | The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2KJ29 | PCGF3 | Polycomb group RING finger protein 3 | Bos taurus (Bovine) | PR |
| A0JN86 | PCGF5 | Polycomb group RING finger protein 5 | Bos taurus (Bovine) | PR |
| Q3KNV8 | PCGF3 | Polycomb group RING finger protein 3 | Homo sapiens (Human) | PR |
| Q9BYE7 | PCGF6 | Polycomb group RING finger protein 6 | Homo sapiens (Human) | PR |
| Q86SE9 | PCGF5 | Polycomb group RING finger protein 5 | Homo sapiens (Human) | PR |
| Q8BTQ0 | PcgF3 | Polycomb group RING finger protein 3 | Mus musculus (Mouse) | PR |
| Q3UK78 | Pcgf5 | Polycomb group RING finger protein 5 | Mus musculus (Mouse) | PR |
| Q07G17 | pcgf3 | Polycomb group RING finger protein 3 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q1JPS1 | pcgf5b | Polycomb group RING finger protein 5-B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATHRKHLVR | DFNRYITCSI | CRGYLIKPTA | VTECLHTFCK | SCIVQHFEES | NECPECGIQV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HETNPLEMLR | LDKTLEEIIF | KLVPGLREKE | EHQESEFWRK | HKIKSNGEDG | PRAKKSRLSG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EDDDGNGGDY | HRSDPQIAIC | LDCLRNNGQS | GESIVKGLMK | KFIRCSTRVT | VGTIKKFLCV |
| 190 | 200 | 210 | 220 | 230 | |
| KLKLPSSYEL | DVLCNGEIMG | KDHTLEFIYR | TRWRLQGDSA | YPMVLEYRPR | IDFG |