AiPD: Autoinhibited Protein Database

Q86SE9

Gene name	PCGF5 (RNF159)
Protein name	Polycomb group RING finger protein 5
Names	RING finger protein 159
Species	Homo sapiens (Human)
KEGG Pathway	hsa:84333
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

55-187 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

55-187 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q86SE9

Entry ID	Method	Resolution	Chain	Position	Source
4S3O	X-ray	200 A	C/F	1-109	PDB
AF-Q86SE9-F1	Predicted				AlphaFoldDB

108 variants for Q86SE9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA5598949 rs759838829	3	T>N		No	ClinGen ExAC gnomAD
rs1177227922 CA377794770	7	H>Y		No	ClinGen TOPMed
TCGA novel	9	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5598951 rs775415140	10	K>E		No	ClinGen ExAC gnomAD
CA377794810 rs1265517654	12	F>C		No	ClinGen gnomAD
rs976386285 CA211984494	12	F>I		No	ClinGen Ensembl
rs1589377262 CA377794842	17	T>P		No	ClinGen Ensembl
CA5598952 rs372696858	19	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA377794857 rs1454147858	19	Y>H		No	ClinGen TOPMed
CA5598953 rs764060027	27	K>E		No	ClinGen ExAC gnomAD
rs1448969907 CA377794927	29	T>S		No	ClinGen gnomAD
rs761358364 CA5598955	32	T>A		No	ClinGen ExAC gnomAD
CA5598956 COSM921372 rs764871600	32	T>M	endometrium Variant assessed as Somatic; 4.621e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA377794980 rs1431307337	37	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA5598982 rs778961490	44	V>I		No	ClinGen ExAC gnomAD
CA5598984 rs372569296	50	S>N		No	ClinGen ESP ExAC gnomAD
CA377795399 rs1191189891	52	D>V		No	ClinGen Ensembl
CA5598986 rs530214236	55	R>K		No	ClinGen 1000Genomes ExAC gnomAD
CA377795421 rs768541378	55	R>S		No	ClinGen ExAC gnomAD
CA377795454 rs1420862961	60	V>F		No	ClinGen TOPMed
TCGA novel	69	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750721214 CA211987259	73	N>S		No	ClinGen TOPMed
rs759182214 CA5599014	74	T>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	76	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1263252851 CA377795585	76	E>A		No	ClinGen gnomAD
rs767091903 CA5599015 COSM686102	79	I>V	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs574214042 CA5599016	80	F>L		No	ClinGen 1000Genomes ExAC gnomAD
CA211987260 rs1048644588	81	K>*		No	ClinGen Ensembl
rs765552152 CA5599018	87	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5599019 rs372777415	88	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1454529389 CA377795737	89	Q>*		No	ClinGen gnomAD
CA377795847 rs1303848081	93	R>C		No	ClinGen gnomAD
rs766732374 CA5599042	93	R>H		No	ClinGen ExAC TOPMed gnomAD
CA5599043 rs752133035	96	E>V		No	ClinGen ExAC gnomAD
TCGA novel	98	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	99	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5599044 rs759646412	101	N>S		No	ClinGen ExAC gnomAD
CA377795994 rs1366698781	103	P>A		No	ClinGen gnomAD
rs1195986707 CA377796034	106	N>D		No	ClinGen gnomAD
CA377796055 rs1308771313	107	G>V		No	ClinGen gnomAD
rs1457582441 CA377796146	109	D>G		No	ClinGen gnomAD
CA377796153 rs1184483839	110	D>G		No	ClinGen gnomAD
rs375287111 CA5599065	111	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA211987564 rs760785402	115	D>V		No	ClinGen TOPMed
CA377796192 rs1471884763	116	K>R		No	ClinGen gnomAD
rs151323358 CA5599066	117	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1410498661 CA377796207	118	K>R		No	ClinGen gnomAD
CA5599068 rs756964181	120	D>E		No	ClinGen ExAC TOPMed gnomAD
rs369899767 CA211987565	120	D>G		No	ClinGen ESP TOPMed gnomAD
CA377796237 rs1297756250	122	E>D		No	ClinGen gnomAD
CA377796241 rs957047222	123	G>D		No	ClinGen TOPMed gnomAD
CA5599069 rs373196380	123	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs957047222 CA211987567	123	G>V		No	ClinGen TOPMed gnomAD
CA5599070 rs750339445	124	D>Y		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	128	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779539576 CA5599072	129	D>A		No	ClinGen ExAC TOPMed gnomAD
rs779539576 CA377796285	129	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1490244018 CA377796282	129	D>H		No	ClinGen TOPMed
CA377796289 rs1230889083	130	K>E		No	ClinGen TOPMed
CA211987568 rs766751742	131	D>E		No	ClinGen Ensembl
rs1283091937 CA377796301	131	D>G		No	ClinGen gnomAD
TCGA novel	141	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780666085 CA5599075	144	D>N		No	ClinGen ExAC gnomAD
rs1317766789 CA377796415	147	R>L		No	ClinGen gnomAD
TCGA novel	147	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	151	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA377796455 rs1187059741	153	G>E		No	ClinGen gnomAD
rs780964655 RCV000513312	154	D>missing		No	ClinVar dbSNP
CA377796458 rs1242801229	154	D>N		No	ClinGen gnomAD
CA377796471 rs746372818	155	N>K		No	ClinGen ExAC TOPMed gnomAD
rs774910464 CA5599079	155	N>S		No	ClinGen ExAC gnomAD
rs772638785 CA5599081	158	K>M		No	ClinGen ExAC gnomAD
TCGA novel	161	M>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200475271 CA211988578	161	M>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs747739155 CA5599094	161	M>T		No	ClinGen ExAC gnomAD
rs200475271 CA5599093	161	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1204358468 CA377796551	165	I>V		No	ClinGen TOPMed
rs777571971 CA5599097 COSM921376	166	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA377796584 rs1232977395 COSM428124	170	R>H	Variant assessed as Somatic; 4.709e-05 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1280414510 CA377796591	171	V>A		No	ClinGen TOPMed gnomAD
rs1277784414 CA377796588	171	V>L		No	ClinGen TOPMed
CA377796624 rs1356134439	177	K>Q		No	ClinGen gnomAD
CA377796685 rs1283379493	185	K>R		No	ClinGen gnomAD
rs1238159237 CA377796691	186	L>F		No	ClinGen gnomAD
rs1285438472 CA377796696	187	P>A		No	ClinGen TOPMed gnomAD
CA377796695 rs1285438472	187	P>S		No	ClinGen TOPMed gnomAD
rs775822212 CA5599099	189	S>F		No	ClinGen ExAC gnomAD
rs747593585 CA5599100	190	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1158301669 CA377796759	194	V>G		No	ClinGen gnomAD
rs747459481 CA5599119	197	N>I		No	ClinGen ExAC gnomAD
TCGA novel	197	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM3383080 CA377796920 rs1166303987	216	R>*	Variant assessed as Somatic; 0.0 impact. pancreas [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs781558423 CA5599121	220	E>K		No	ClinGen ExAC gnomAD
CA5599141 COSM1349761 rs755316155	223	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
COSM921378 rs751887657 CA5599140	223	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1347797101 CA377794500	227	C>S		No	ClinGen TOPMed
CA211989608 rs377561962	228	S>P		No	ClinGen ESP TOPMed gnomAD
rs748687822 CA5599143	230	S>W		No	ClinGen ExAC gnomAD
TCGA novel	231	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5599145 rs777886510	234	S>C		No	ClinGen ExAC gnomAD
rs771114816 CA5599147	235	Q>R		No	ClinGen ExAC gnomAD
rs1253851433 CA377794587	240	Y>D		No	ClinGen gnomAD
rs779153610 CA5599166	242	S>P		No	ClinGen ExAC gnomAD
rs1172620363 CA377794632	244	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA211990288 rs920325293	245	M>V		No	ClinGen TOPMed
CA377794645 rs1185746673	246	V>G		No	ClinGen TOPMed
rs1037344299 CA211990289	246	V>I		No	ClinGen TOPMed gnomAD
CA377794690 rs1489707168	253	I>T		No	ClinGen gnomAD

No associated diseases with Q86SE9

3 regional properties for Q86SE9

Type	Name	Position	InterPro Accession
domain	Zinc finger, RING-type	18 - 56	IPR001841
conserved_site	Zinc finger, RING-type, conserved site	34 - 43	IPR017907
domain	RAWUL domain	163 - 216	IPR032443

Functions

		Description
EC Number
Subcellular Localization	Nucleus Nucleus, nucleoplasm	Recruited by the non-coding RNA Xist to specific nuclear foci that probably correspond to the inactivated X chromosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
centrosome	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
PcG protein complex	A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.
PRC1 complex	A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling.
X chromosome	The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males.

1 GO annotations of molecular function

Name	Definition
metal ion binding	Binding to a metal ion.

4 GO annotations of biological process

Name	Definition
histone H2A-K119 monoubiquitination	The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms.
inactivation of X chromosome by genomic imprinting	Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by genomic imprinting.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

9 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2KJ29	PCGF3	Polycomb group RING finger protein 3	Bos taurus (Bovine)	PR
A0JN86	PCGF5	Polycomb group RING finger protein 5	Bos taurus (Bovine)	PR
Q3KNV8	PCGF3	Polycomb group RING finger protein 3	Homo sapiens (Human)	PR
Q9BYE7	PCGF6	Polycomb group RING finger protein 6	Homo sapiens (Human)	PR
Q8BTQ0	PcgF3	Polycomb group RING finger protein 3	Mus musculus (Mouse)	PR
Q3UK78	Pcgf5	Polycomb group RING finger protein 5	Mus musculus (Mouse)	PR
Q07G17	pcgf3	Polycomb group RING finger protein 3	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
B3DK16	pcgf5a	Polycomb group RING finger protein 5-A	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q1JPS1	pcgf5b	Polycomb group RING finger protein 5-B	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MATQRKHLVK	DFNPYITCYI	CKGYLIKPTT	VTECLHTFCK	TCIVQHFEDS	NDCPRCGNQV
70	80	90	100	110	120
HETNPLEMLR	LDNTLEEIIF	KLVPGLREQE	LERESEFWKK	NKPQENGQDD	TSKADKPKVD
130	140	150	160	170	180
EEGDENEDDK	DYHRSDPQIA	ICLDCLRNNG	QSGDNVVKGL	MKKFIRCSTR	VTVGTIKKFL
190	200	210	220	230	240
SLKLKLPSSY	ELDVLCNGEI	MGKDHTMEFI	YMTRWRLRGE	NFRCLNCSAS	QVCSQDGPLY
250
QSYPMVLQYR	PRIDFG