AiPD: Autoinhibited Protein Database

Q3KNV8

Gene name	PCGF3 (RNF3, RNF3A)
Protein name	Polycomb group RING finger protein 3
Names	RING finger protein 3A
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10336
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

59-183 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

59-183 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q3KNV8

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3KNV8-F1	Predicted				AlphaFoldDB

131 variants for Q3KNV8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	1	M>?	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2796420 rs530546353	5	K>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2796422 rs764423351	10	D>N		No	ClinGen ExAC TOPMed gnomAD
CA355923996 rs372489853	12	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
COSM300490 CA2796424 rs757796778	13	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	15	I>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2796426 rs745974154	15	I>V		No	ClinGen ExAC gnomAD
CA355924017 rs1577414128	16	T>P		No	ClinGen Ensembl
CA2796428 rs780392365	18	R>C		No	ClinGen ExAC TOPMed gnomAD
CA355924031 rs780392365	18	R>G		No	ClinGen ExAC TOPMed gnomAD
CA2796429 rs200875455	18	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA355924032 rs780392365	18	R>S		No	ClinGen ExAC TOPMed gnomAD
rs554120309 CA2796432	21	S>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel rs1577414160 CA355924055	22	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
CA91108638 rs747677396	31	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1407893641 CA355924116	31	T>S		No	ClinGen TOPMed
rs1015568099 CA91108669	36	T>A		No	ClinGen gnomAD
CA2796532 rs780719522	44	K>R		No	ClinGen ExAC gnomAD
CA2796534 rs755855038	49	N>D		No	ClinGen ExAC gnomAD
CA2796535 rs777510767	49	N>K		No	ClinGen ExAC gnomAD
rs1162115308 CA355925792	50	N>H		No	ClinGen TOPMed gnomAD
CA2796536 rs746240016	50	N>S		No	ClinGen ExAC gnomAD
CA355925813 rs1577415322	51	T>N		No	ClinGen Ensembl
CA355925808 rs1406712315	51	T>P		No	ClinGen gnomAD
rs776201377 CA2796538	58	V>L		No	ClinGen ExAC gnomAD
TCGA novel	64	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1283672509 CA355926034	68	I>V		No	ClinGen gnomAD
CA355926045 rs1383962948	69	G>D		No	ClinGen TOPMed
CA2796543 rs770005395	69	G>S		No	ClinGen ExAC TOPMed gnomAD
CA355926649 rs1476416930	78	V>I		No	ClinGen TOPMed
CA91113009 rs776789937	82	V>L		No	ClinGen Ensembl
CA2796570 rs763679381	87	E>D		No	ClinGen ExAC TOPMed gnomAD
CA355926744 rs1577417886	87	E>G		No	ClinGen Ensembl
rs1470005630 CA355926738	87	E>K		No	ClinGen gnomAD
rs1436067837 CA355926750	88	A>P		No	ClinGen gnomAD
rs1436067837 CA355926748	88	A>T		No	ClinGen gnomAD
CA2796591 rs761352143	88	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1366864461 CA355927420 COSM353298	90	M>I	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1161428526 CA355927415	90	M>K		No	ClinGen gnomAD
rs765004074 CA2796592	90	M>V		No	ClinGen ExAC gnomAD
rs750026979 CA2796593	92	K>Q		No	ClinGen ExAC gnomAD
rs538604823 CA2796594	93	Q>H		No	ClinGen 1000Genomes ExAC gnomAD
rs1393156105 CA355927508	95	E>D		No	ClinGen gnomAD
rs753019717 CA2796596	97	Y>C		No	ClinGen ExAC gnomAD
TCGA novel	99	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA355927588 rs1351009952	101	G>S		No	ClinGen TOPMed gnomAD
rs975371130 CA91118528	105	P>L		No	ClinGen TOPMed gnomAD
rs201716638 CA2796598	108	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA2796599 rs749376888	108	I>T		No	ClinGen ExAC gnomAD
CA2796600 rs757281166	109	K>E		No	ClinGen ExAC gnomAD
rs1481885244 CA355927739	110	G>E		No	ClinGen gnomAD
CA355927732 rs1577424197	110	G>R		No	ClinGen Ensembl
rs1251603437 CA355927753	111	E>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1465600607 CA355927747	111	E>Q		No	ClinGen TOPMed
rs779253635 CA2796601	114	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA355927814 rs1483667569	114	S>P		No	ClinGen gnomAD
rs746055497 CA2796602	115	A>T		No	ClinGen ExAC TOPMed gnomAD
CA355927850 rs1423252969	117	Q>K		No	ClinGen TOPMed gnomAD
rs1207652348 CA355927909	120	D>V		No	ClinGen TOPMed
rs34993692 CA2796603	122	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA2796605 rs746754950	123	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
COSM1057295 rs201626789 CA2796604	123	R>W	ovary Variant assessed as Somatic; 0.0 impact. endometrium [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA2796607 rs370347182	125	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs764421125 CA2796632	126	E>D		No	ClinGen ExAC gnomAD
rs1172676581 CA355928349	127	T>I		No	ClinGen TOPMed
CA2796633 rs183503213	128	K>N		No	ClinGen 1000Genomes ExAC gnomAD
CA91119553 rs369600342	129	A>V		No	ClinGen gnomAD
rs1386368450 CA355928385	130	D>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA355928387 rs1456214840	131	D>H		No	ClinGen TOPMed gnomAD
rs1456214840 CA355928398	131	D>N		No	ClinGen TOPMed gnomAD
rs1456214840 CA355928389	131	D>Y		No	ClinGen TOPMed gnomAD
rs765730151 CA2796635	132	S>T		No	ClinGen ExAC gnomAD
CA2796636 rs573005305	134	N>H		No	ClinGen 1000Genomes ExAC gnomAD
rs758440465 CA2796637	136	E>G		No	ClinGen ExAC TOPMed gnomAD
CA91119577 rs1048353837	136	E>Q		No	ClinGen TOPMed gnomAD
CA355928493 rs1202740786	137	A>S		No	ClinGen TOPMed
rs1202740786 CA355928491	137	A>T		No	ClinGen TOPMed
rs960588934 CA91119586	138	A>S		No	ClinGen TOPMed
rs1321433235 CA355928510	138	A>V		No	ClinGen TOPMed
CA355928519 rs1208129740	139	E>A		No	ClinGen gnomAD
rs1373108915 CA355928514	139	E>K		No	ClinGen TOPMed
rs1560210239 CA355928545	140	E>D		No	ClinGen Ensembl
rs1577425362 CA355928563	141	K>N		No	ClinGen Ensembl
rs1012267189 CA355928559	141	K>R		No	ClinGen TOPMed
CA91119613 rs1012267189	141	K>T		No	ClinGen TOPMed
CA2796641 rs751806861	142	P>L		No	ClinGen ExAC TOPMed gnomAD
CA2796640 rs751806861	142	P>R		No	ClinGen ExAC TOPMed gnomAD
rs201838189 CA91119696	145	D>G		No	ClinGen TOPMed
rs1426568919 CA355928609	145	D>N		No	ClinGen TOPMed
rs747926473 CA2796643	146	N>D		No	ClinGen ExAC gnomAD
rs769631183 CA2796644	146	N>S		No	ClinGen ExAC TOPMed
rs1201361722 CA355928654	148	Y>C		No	ClinGen gnomAD
rs777697943 CA2796645	151	S>R		No	ClinGen ExAC
CA91119751 rs370937234	152	D>E		No	ClinGen ESP ExAC TOPMed
rs1473620756 CA355928729	153	E>Q		No	ClinGen TOPMed
CA2796690 rs746639007	155	V>L		No	ClinGen ExAC gnomAD
rs1199863296 CA355913970	161	C>Y		No	ClinGen gnomAD
CA355913985 rs1278695006	162	N>H		No	ClinGen gnomAD
rs561952925 CA2796692	164	S>N		No	ClinGen 1000Genomes ExAC gnomAD
COSM1430916 CA355914097 rs1206319800	167	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1246980678 CA355914100	167	R>H		No	ClinGen TOPMed gnomAD
rs547312640 CA2796694 CA2796695	168	G>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1407477560 CA355914150	171	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA355914172 rs1345760851	172	K>R		No	ClinGen gnomAD
CA355914238 rs1318646361	175	R>C		No	ClinGen TOPMed gnomAD
rs1388151810 CA355914250	175	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1577446157 CA355914294	178	A>G		No	ClinGen Ensembl
CA2796700 rs764173690	179	Q>H		No	ClinGen ExAC gnomAD
rs753649606 CA2796701	180	A>V		No	ClinGen ExAC gnomAD
CA355914525 rs1289292011	189	I>V		No	ClinGen TOPMed
rs768253505 CA2796708	191	K>N		No	ClinGen ExAC gnomAD
TCGA novel	192	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs34100269 CA355914658 CA2796711	194	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA355914667 rs1264845260	195	L>F		No	ClinGen gnomAD
CA91088189 rs868301100	196	S>L		No	ClinGen Ensembl
CA355914715 rs1577446208	198	F>S		No	ClinGen Ensembl
CA355914744 rs1303295946	200	E>K		No	ClinGen TOPMed
TCGA novel	202	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA91092083 rs528066967	203	I>V		No	ClinGen Ensembl
rs747454523 CA2796755	207	E>K		No	ClinGen ExAC gnomAD
TCGA novel	208	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
RCV001197055 rs1745284197	214	H>Y		No	ClinVar dbSNP
rs1452876761 CA355915992	215	T>I		No	ClinGen TOPMed
CA355916045 rs200620611	218	F>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs768601750 CA2796808	229	A>V		No	ClinGen ExAC TOPMed gnomAD
rs761316369 CA2796810	230	P>L		No	ClinGen ExAC gnomAD
rs1403288201 CA355916564	234	H>Q		No	ClinGen gnomAD
CA2796815 rs753019870	234	H>Y		No	ClinGen ExAC gnomAD
rs764604416 CA2796817	236	R>K		No	ClinGen ExAC gnomAD
CA91093445 rs1029081275	239	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1375796949 CA355916614	241	L>F		No	ClinGen gnomAD

No associated diseases with Q3KNV8

3 regional properties for Q3KNV8

Type	Name	Position	InterPro Accession
domain	Zinc finger, RING-type	17 - 56	IPR001841
conserved_site	Zinc finger, RING-type, conserved site	33 - 42	IPR017907
domain	RAWUL domain	172 - 236	IPR032443

Functions

		Description
EC Number
Subcellular Localization	Nucleus Nucleus, nucleoplasm	Recruited by the non-coding RNA Xist to specific nuclear foci that probably correspond to the inactivated X chromosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
PcG protein complex	A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.
PRC1 complex	A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling.
X chromosome	The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males.

1 GO annotations of molecular function

Name	Definition
metal ion binding	Binding to a metal ion.

3 GO annotations of biological process

Name	Definition
histone H2A-K119 monoubiquitination	The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms.
inactivation of X chromosome by genomic imprinting	Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by genomic imprinting.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

9 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A0JN86	PCGF5	Polycomb group RING finger protein 5	Bos taurus (Bovine)	PR
Q2KJ29	PCGF3	Polycomb group RING finger protein 3	Bos taurus (Bovine)	PR
Q9BYE7	PCGF6	Polycomb group RING finger protein 6	Homo sapiens (Human)	PR
Q86SE9	PCGF5	Polycomb group RING finger protein 5	Homo sapiens (Human)	PR
Q3UK78	Pcgf5	Polycomb group RING finger protein 5	Mus musculus (Mouse)	PR
Q8BTQ0	PcgF3	Polycomb group RING finger protein 3	Mus musculus (Mouse)	PR
Q07G17	pcgf3	Polycomb group RING finger protein 3	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q1JPS1	pcgf5b	Polycomb group RING finger protein 5-B	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
B3DK16	pcgf5a	Polycomb group RING finger protein 5-A	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MLTRKIKLWD	INAHITCRLC	SGYLIDATTV	TECLHTFCRS	CLVKYLEENN	TCPTCRIVIH
70	80	90	100	110	120
QSHPLQYIGH	DRTMQDIVYK	LVPGLQEAEM	RKQREFYHKL	GMEVPGDIKG	ETCSAKQHLD
130	140	150	160	170	180
SHRNGETKAD	DSSNKEAAEE	KPEEDNDYHR	SDEQVSICLE	CNSSKLRGLK	RKWIRCSAQA
190	200	210	220	230	240
TVLHLKKFIA	KKLNLSSFNE	LDILCNEEIL	GKDHTLKFVV	VTRWRFKKAP	LLLHYRPKMD

LL