Q06493
Gene name |
YLH47 (MRS7, YPR125W) |
Protein name |
LETM1 domain-containing protein YLH47, mitochondrial |
Names |
LETM1 homolog |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YPR125W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q06493
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q06493-F1 | Predicted | AlphaFoldDB |
5 variants for Q06493
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s16-787972 | 6 | S>P | No | SGRP | |
| s16-788011 | 19 | G>R | No | SGRP | |
| s16-788084 | 43 | N>S | No | SGRP | |
| s16-788129 | 58 | K>R | No | SGRP | |
| s16-788573 | 206 | E>G | No | SGRP |
No associated diseases with Q06493
1 regional properties for Q06493
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | LETM1-like, ribosome-binding domain | 119 - 371 | IPR033122 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| ribosome binding | Binding to a ribosome. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular metal ion homeostasis | Any process involved in the maintenance of an internal steady state of metal ions at the level of a cell. |
| potassium ion transport | The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| protein insertion into mitochondrial inner membrane from matrix | The process in which a protein is incorporated into the mitochondrial inner membrane from the matrix side. This includes membrane insertion of newly synthesized mitochondrially-encoded proteins, and insertion of nuclear-encoded proteins after their import into the mitochondrial matrix. |
| proton transmembrane transport | The directed movement of a proton across a membrane. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A3KN46 | LETMD1 | LETM1 domain-containing protein 1 | Bos taurus (Bovine) | PR |
| Q0VCA3 | LETM1 | Mitochondrial proton/calcium exchanger protein | Bos taurus (Bovine) | PR |
| Q5ZK33 | LETM1 | Mitochondrial proton/calcium exchanger protein | Gallus gallus (Chicken) | PR |
| Q2VYF4 | LETM2 | LETM1 domain-containing protein LETM2, mitochondrial | Homo sapiens (Human) | PR |
| O95202 | LETM1 | Mitochondrial proton/calcium exchanger protein | Homo sapiens (Human) | PR |
| Q924L1 | Letmd1 | LETM1 domain-containing protein 1 | Mus musculus (Mouse) | PR |
| Q7TNU7 | Letm2 | LETM1 domain-containing protein LETM2, mitochondrial | Mus musculus (Mouse) | PR |
| Q9Z2I0 | Letm1 | Mitochondrial proton/calcium exchanger protein | Mus musculus (Mouse) | PR |
| Q5PQQ5 | Letm2 | LETM1 domain-containing protein LETM2, mitochondrial | Rattus norvegicus (Rat) | PR |
| Q5XIN6 | Letm1 | Mitochondrial proton/calcium exchanger protein | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLKYRSLPIK | RAIHHPAPGI | TPISPRIMVS | RLRVIPSFNL | KFNRWNSSVP | ESSKKELKTT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DGNQESASKV | SPVKEKEKVP | FKVKMQKALR | HYWDGSKLLG | LEIKISSKLL | MKSAAGYPLT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RRENLQLKRT | TQDIVRLVPF | AAFLIIPFAE | LLLPFALKLF | PNLLPSTYES | SKKRENKLEN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LRNTRKLMSE | IIKNNKSHFK | PNNISEEQKA | LFNRFYTHVR | ATGVPESRQQ | LIEVARLFTD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DTVLDNVTRP | YLIALAKYMN | LQPFGTDVML | RYRIRYKMLE | LKKDDLSIYY | EDAEQLSLSE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LKTACASRGI | RSVDVEPSVL | YSNLRLWLNM | RLKDKIPSTL | LIMATAYNYG | NVQSKESLYD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ALCDVLIGIP | DELYHEVKVN | VVKEDEASAK | QKLKQLREQE | EIMKEEEQQE | ENAIVSVKDE |
| 430 | 440 | 450 | |||
| LSLDDQDKNI | DAAAPDVKPH | DTKPIGEAAA | IKEK |